RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH. Based on the findings of hypokalemia, metabolic alkalosis, normal serum aldosterone, makedly elevated ACTH and cortisol levels and a history of widespread metastatic prostate carcinoma, the patient was diagnosed as refractory hypokalemia due to Ectopic ACTH production.
His anemia and thrombocytopenia were thought to be secondary to marrow involvement by metastatic prostate carcinoma.
Pseudo-Cushing's Syndrome (Severe obesity, major depressive disorder, chronic alcoholism, severe bacterial infection). The serum electrolyte abnormalities are more common in ectopic ACTH syndrome than other forms of Cushing's syndrome.
Patients with ectopic ACTH syndrome have excessively high cortisol and elevated ACTH levels, hypokalemia, metabolic alkalosis and glucose intolerance.
Cushing's syndrome is caused by ectopic ACTH or corticotropin-releasing hormone (CRH) production in 10-20% of cases. Patient's with ectopic Cushing's syndrome secondary to carcinoma often lack the clinical manifestations associated with classic Cushing's syndrome. Evidence suggests that ACTH levels correlate with the degree of metastasis or rapid tumor growth.
Immunohistochemical staining of tumors for ACTH is insufficient evidence to rule out biosynthesis or activity of these hormones. Medical interventions include potassium replacement and spironolactone and steroid biosynthesis inhibitors (ketoconazole, metyrapone, etomidate and mitotane). Prognosis of patient's with ectopic ACTH is correlated with the histology of tumor and severity of hypercorticolism. Rickman T, Garmany R, Doherty T, Benson D, Okusa MD Hypokalemia, metabolic alkalosis, and hypertension:Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. Alwani RA, Neggers SJ, van der Klift M, Baggen MG, van Leenders GJ, van Aken MO, van der Lely AJ, de Herder WW, Feelders RA.
Salgado LR, Fragoso MC, Knoepfelmacher M, Machado MC, Domenice S, Pereira MA, De Mendonca BB Ectopic ACTH syndrome: our experience with 25 cases. Chia is the highest plant based source of omega-3, dietary fibre, protein and antioxidants.
The protein in chia contains all nine essential amino acids, making it a ‘complete’ protein.
Omega-3 is a vital nutrient for brain function and overall health and vitality, while chia’s high levels of both soluble and insoluble fibre can aid digestion, helping you to feel fuller for longer and can also help maintain healthy levels of cholesterol.
Wholefoods are beneficial as they contain high concentrations of complex micronutrients, antioxidants, fibers and many other phytochemicals which are often missing from processed foods. When developing our ready-to-eat product line our commitment to global health remains a driving factor. The Heart Foundation recommends that you consume plant based Omega-3 ALA every day and Omega-3 EPA DHA, found in fish, twice a week. The antioxidants found in our Chia seeds essentially combat oxidization, which is a naturally occurring process in our bodies caused by sun exposure or pollution. Our Chia seeds contain a whole lot of other goodness that’s essential for your health and wellbeing. Iron Iron is a component of several proteins, the most important of which is hemoglobin, which transports oxygen to tissues and organs like the heart and muscles, as well as many others. Phosphorus One of the main components of bone structure is phosphate, which is supplied to the body by phosphorus.
Potassium Blood pressure regulation, maintaining the right level of water in your fat cells and muscle tissues and the proper functioning of cells are just some of the roles of this important mineral. To keep our foods vegan friendly, we use coconut milk and oil in our ready-to-eat products as an alternative to dairy.
MCFAs found in foods such as coconuts are metabolised in the liver and are converted to vital fuel for our brain and muscles, rather than being stored as fats.
Coconut oil is also a remarkable source of lauric acid, a substance which is highly prized by our bodies for its antiviral properties. As well as offering protection against bacteria and viruses, lauric acid has been linked with increasing metabolic rate and improving the condition of skin and hair.
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For thousands of years, many cultures have used the health benefits of tea in all aspects of their daily life.
Produced from the leaves of the Camellia Sinensis, tea is one of the most popular beverages on the planet – second only to water in consumption. Skin care companies tout the anti-aging qualities of tea, adding extracts of various teas to skin creams, soaps and moisturizers. It has been used as an effective home health remedy for generations to soothe indigestion and calm diarrhea.
Tea fosters a calm mood while simultaneously revitalizing your brain’s ability to focus and think clearly. Drinking tea daily can provide a myriad of health benefits and protect you against some of the most debilitating diseases known. Green Tea (Most popular: Japanese, Chinese, Ceylon and Kahwah) has far more proven health benefits than other teas do because it has garnered the most research. Harvard Women’s Health Watch published their findings on the powerful antioxidant benefits of the flavonoids – primarily catechins, also known as ECGC – found in green tea.
They found that these compounds aid in weight loss, prevent DNA damage, lessen brain damage after a stroke and reduce the risk of cancer. Black Tea (Most popular: Assam, Nepal, Darjeeling and Nilgiri ) is the most common tea, accounting for 75% of all tea consumed around the world. White Tea (Most popular: Silver Needle, White Peony, Long Life Eyebrow and Tribute Eyebrow ) has a milder taste than green or black tea, has less adverse effects – even when you drink as many as five cups a day – and is now widely available.
A staple in Eastern households for more than a thousand years, white tea is gaining popularity in the Western world. Because white tea is rare and more expensive than other teas, it may not be a first choice for avid tea drinkers. Additionally, research is limited on this variety of tea but initial results show it may just surpass the recognized cancer-fighting benefits of green tea.
Oolong Tea (Most popular: Darjeeling, Assam, Vietnamese and Thai ) is processed differently than green or black tea. It’s less oxidized than black tea, which gives it an increased concentration of polyphenols, that can reduce the risk of cardiovascular disease and help lower blood sugar levels.
Oolong tea has even proven effective in preventing oral bacteria according to the Department of Dentistry at Osaka University in Japan.
The American Chemical Society (ACS) found that bottled teas boasting “antioxidant protection” on their labels may contain less polyphenols than a cup of green or black tea brewed at home. Adding in high amounts of sugar and other additives further reduces the health benefits of bottled tea. Tea made at home costs just a few cents, compared to bottled teas that can cost two dollars or more. Tea sales – both bottled and fresh – have risen in recent years due to promising research in the scientific community. Subscribe To Our NewsletterYou'll get instant access to your free e-book Coconut Oil Cures: The Ultimate Solution for Anti-Aging, Weight Loss, Disease Prevention and Health Restoration via email. The generation of hypokalemia, metabolic alkalosis and hypertension were likely the result of sustained activation of mineralocorticoid receptors by high levels of circulating cortisol.
Only one of three patients with classic Cushing's syndrome has hypokalemia and metabolic alkalosis. The spectrum of non-pituitary tumors associated with ACTH production includes neuroendocrine tumors of respiratory and gastrointestinal tract, small cell lung cancer (SCLC), medullary thyroid carcinoma, and pheochromocytoma.
Presenting symptoms of ectopic ACTH can include rapid progressive weakness and weight loss. Study by Coates et al in 18 tumors causing ectopic Cushing's syndrome found greatest ACTH levels in rapidly growing tumors with widespread metastasis. It has been suggested that cells of highly malignant tumors causing Cushing's syndrome have a high secretion rate and do not store sufficient hormone for immunostaining. However in as many as one third of patients surgery or radiation are not therapeutic options. Cushing's syndrome due to ectopic ACTH production by (neuroendocrine) prostate carcinoma Pituitary.2008 Mar 6. Kaltsas GA, Pozza C, Frajese V, Newell-Price J, Reznek, RH, Jenkins PJ, Monson JP, Grossman a B, BesserGM.
This is incredibly rare for a plant based source of protein, and makes chia particularly beneficial for vegetarians and vegans. Chia is one of few grain-like seeds that can be eaten completely in its natural state – no grinding, no cooking and no processing.
Diets rich in wholefoods have been identified as protective against chronic diseases including cancer, due to the synergy of antioxidants and phytochemicals. We only use ‘real food’ ingredients, steering clear of artificial flavors, emulsifiers or preservatives.
This kind of Omega-3 is particularly important to the heart by helping lower cholesterol and helping to maintain proper artery function, thereby helping reduce cardiovascular disease.


The type of Omega-3 ALA found in Chia is recommended for consumption daily to maintain your heart and overall health. Some of the Omega-6 in Chia will be converted to Gamma Linolenic Acid (GLA) and Arachidonic Acid (AA), which, according to research can be beneficial for anti-inflammation, joint mobility and heart function. Each individual type of protein is made from a specific chain of amino acids linked together. Phosphorus helps your body’s calcium be as effective as possible while also maintaining the health of the kidneys and regulating your fluid level. Happily for those who can’t tolerate gluten when it comes into contact with their small intestine (known as coeliac disease), Chia is 100% gluten-free. Pure coconut oil is the most abundant natural source of of lauric acid, containing almost 50% which is comparable only to the levels found in breast milk. I hope The maximum social security withholding for 2016, For the first time in many years, the social security maximum will not increase in 2016. A study by Beiersdorf AG found that white tea extracts not only prevented fat absorption, but also broke down the fat of lab-created human fat cells.
The polyphenols found in all tea varieties have some of the highest free radical scavenging ability, (free radicals promote oxidation, which scientists now believe causes cancer). Accelerates Weight Loss: High concentrations of the aflavins and the arubigins fight the absorption of fat in rats fed a diet high in fat. Boosts Immunity: Tea is both antiviral and antibacterial due to compounds known as alkylamines.
Prevents Heart Disease: Tea reduces your risk of high blood pressure, prevents blood clots and keeps blood vessels relaxed. Strengthen Nervous System: Tea polyphenols stimulate the nervous system and increase brain alertness.
Lowers Diabetes: Research compiled by the Leibniz Center for Diabetes Research at Heinrich Heine University Duesseldorf, Germany found that consuming four cups of tea each day reduces your risk of developing type II diabetes by 20%. Increases Bone Density: Scientific studies done at the University of Cambridge School of Medicine showed that tea drinkers have 5% stronger bones than non-tea drinkers. In the United States, bottled beverages generate approximately one billion dollars in sales annually. Poly phenol-abundant tea has been linked to reducing the risks of heart disease and obesity. However, as more extensive research is done, we will likely find ever more reason to relax with a cup of tea. Plus, you'll also receive eAlerts from the Underground Health Reporter to help you stay on top of the latest healing breakthroughs from the world of nutrition and dietary supplements. The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up. Amino acids are the building blocks of our bodies, and are essential for healthy muscles, hair, skin and nails.
This form of fibre has many benefits, including moderating blood glucose levels and lowering cholesterol. Omega-3 ALA can be partially converted to Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA), which studies have shown can be beneficial for brain function, mood disorders and cardiovascular health. Amino acids are vital to life, and while most can be synthesised in our bodies, there are nine 'essential' amino acids which must be absorbed in our diets.
It also plays a vital role in maintaining a healthy heart by stabilizing its rhythm and helping prevent abnormal blood clotting.
In fact, the lauric acid in breast milk is considered a key factor to breast-fed babies' natural resistance to infections. Green and Oolong teas also boost your metabolism and naturally increase your energy levels.
One study in Europe showed that one cup of tea each day could reduce the risk of heart attack by 50%! They also protect brain cells and slow deterioration caused by neuro-degenerative diseases such as Alzheimer’s and Parkinson’s. While coffee seems to weaken bone density, the flavonoids in tea counteract the caffeine and strengthen it. How much you convert depends on many factors like your diet and fitness levels which is why it is recommended that you eat both plant based and some marine based Omega-3.
Studies show that a diet rich in antioxidants can slow the aging process in the body as well as the brain, while also reducing the effects of chronic diseases such as Alzheimer’s and muscle degeneration. Unlike higher caffeine beverages, tea stimulates brain function without causing stress to the heart. Antioxidant levels are measured by their Oxygen Radical Absorbance Capacity, or ORAC score.



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