A low glycemic index diet is one of the best ways to look after your health, and lose excess weight effectively and naturally.
High GI (70-100) Carbohydrates which break down quickly during digestion, releasing blood sugar rapidly into the bloodstream – causing marked fluctuations in blood sugar levels. Medium GI (56-69) Carbohydrates which break down moderately during digestion, releasing blood sugar moderately into the bloodstream. Low GI (0-55) Carbohydrates which break down slowly during digestion, releasing blood sugar gradually into the bloodstream – keeping blood sugar levels steady … and so provide you with the best health benefits!
When referring to any GI Food List, please remember that the numbers aren’t absolute and should serve as a guide only. The glycemic index ratings of individual foods will vary according to ripeness, variety, product brand, specific ingredients used, cooking times, and GI testing procedures. These figures come out when you measure your blood sugar level in the morning after have been fasting for at least 8 hours.This is the time between the dinner and your breakfast.
Is your Diabetic Heart Killing you softly?Get to know about Diabetes Heart Failure link to more severe complications. 1-Stop resource for health-related information and online directory of general physicians and specialists in the Philippines. Vildagliptin is a member of the dipeptidyl peptidase IV inhibitor (DPP-IV inhibitor) class of drugs. Recent studies suggest that glucose variability may play a significant role in the risk for diabetic complications. The significance of this study is to determine the effect of vildagliptin compared to glimepiride in improving glycemia by assessing its effect on acute glucose fluctuations which can contribute to the development of diabetic complications. The purpose of this study is to compare the effect of Vildagliptin (Galvus) and Glimepiride(Solosa) on glucose variability among Type 2 Diabetes patients not controlled on Metformin alone. To determine and compare the 24 hour glycemic profile of the 2 treatment arms using the mean glucose values obtained from the 7 point capillary blood glucose monitoring of the study subjects. To compare the effect of vildagliptin and glimepiride on the postprandial glucose excursions of patients between the two treatment arms. To compare the glucose variability between the two treatment arms using the mean amplitude of glycemic excursions (MAGE).
The investigation was a prospective, interventional, randomized, open-labeled, active control, parallel assignment, efficacy study. Inclusion Criteria included all adult patients between 18-80 years of age diagnosed with type 2 Diabetes Mellitus for less than 10 years, with Hbaic level between 6.5%-10% (NGSP certified) and body mass index of 20-35, with inadequate glycemic control with metformin (at least 1000 mg) for at least one month. Female patients who were included were advised to use contraception and in case they got pregnant, they were pulled out from the study. Mean Amplitude of Glycemic Excursions (MAGE) – parameter used to quantify glucose variability, obtained by measuring the arithmetic mean of the glucose increases or decreases (from blood glucose nadirs to peaks and vice versa) when both ascending and descending segments exceeded the value of one standard deviation of the blood glucose for the same 24 hour period. The MAGE was calculated using the glucose values obtained from the seven-point blood sugar monitoring of each patient.
In determining the treatment effect, time effect, and combined treatment and time effect on the MAGE, AUCpp and mean glucose values from the 7 point capillary blood glucose monitoring, between-within repeated measures analysis of variance was used.
Table 1 shows the clinical and metabolic profile of the subjects in both Vildagliptin and Glimepiride arms. The mean glucose values using the 7-point capillary blood glucose monitoring of subjects from both treatment arms were plotted against time to generate a 5-week blood glucose profile (Figure1). Differences in the blood glucose values between the two treatment arms across days of observation were likewise analyzed and showed no significant difference. Based on these findings, both vildagliptin and glimepiride resulted to improved blood glucose values of the subjects in both treatment arms and both treatments were found to be comparable in their blood sugar lowering effect.


Comparability of effect was further analyzed when the highest and the lowest blood sugars were compared. To compare for the postprandial glucose excursions of patients in each treatment arm, the mean postprandial incremental area under the curve (AUCpp) was computed.
The overall AUCpp of subjects in the Vildagliptin and Glimepiride arms were also not found to be significantly different from each other. The mean amplitude of glycemic excursions (MAGE) of the patients from the two study groups were likewise computed and graphed from Day 1 to Day 35 (Figure 4).
When the overall MAGE of the subjects in the Vildagliptin arm from day 1 to 35 was compared with the MAGE of the subjects in the Glimepiride arm, it was also not found to be significantly different.
Although this study did not reach statistical significance, it was shown that even if vildagliptin and glimepiride can both improve glycemia of patients with uncontrolled blood sugar on monotherapy with metformin, as seen by both having downward glucose profiles of both study arms from the start of the study towards week 5 and with comparable levels of glucose at the end of the study, vildagliptin had a less abrupt glucose lowering effect as compared to glimepiride, suggesting lesser risk of hypoglycemia. However, comparison of the two treatments may not be fully established in this study as statistical power was not reached in most of the analysis due to the inadequate sample size.
I specialize in adult diseases, diabetes, thyroid problems, diseases of the pituitary gland, adrenal glands and other hormones as well as bone-related diseases such as osteoporosis and vitamin D deficiency.
Blood glucose in the diabetic rises and stays above normal.The healthy person regulates their glucose back to normal.
Every cell in the body needs a supply of glucose to maintain respiration and generate energy for all of its processes. The weight reduced through a low GI diet approach is safe, and you won’t find yourself needing to starve on just carrots and lettuce! These foods help in keeping the blood sugar levels stable, are beneficial for sports persons, diabetics, people with coronary heart disease, those wanting to lose weight … and really just about everyone!
The impact any particular food will have on your blood sugar levels on any given day will depend on many other factors such as ripeness, cooking time, product brand, fibre and fat content, time of day, blood insulin levels, and recent activity. Alba, What would be the glucose reaction if I eat 2 scrambled eggs with 2 slices of salt-cured bacon and one slice of wholegrain toast?
These drugs are believed to improve glucose variability by restoring the physiologic pattern of insulin secretion. These studies show that glucose variability is more deleterious to endothelial function and oxidative stress than mean glucose or sustained chronic hyperglycemia4,5.
The calculated sample size for the study was 42 patients, 21 patients for each study arm, but was cut down to 18 patients due to budget constraints.
Patients on other oral hypoglycemic agents other than metformin, or on insulin were excluded from the study.
For comparing qualitative clinical profile variables between the two study arms, chi-square test was used while quantitative clinical and metabolic profile variables were compared between the two groups using independent t-tests.
Subjects in both the Vildagliptin arm and the Glimepiride arm showed a downward trend in the blood glucose values from day 1 to 35. However, significance of their comparability of effect cannot be concluded from these data as statistical significance was not reached due to inadequate sample size. The mean AUCpp of the patients from both treatment arms were plotted from Day 1 to Day 35 of the study period (Figure 3). The effect of vildagliptin on postprandial glucose excursions which can be attributed to its incretin effect on beta and alpha cells was not seen to be superior to sulfonylurea in this study based on the AUCpp. A drop of blood is placed on a test strip and the monitor displays the blood glucose concentration. Levels of glucose (sugar) in the blood are closely controlled by two hormones; insulin and glucagon.
It causes the liver to convert glycogen back to glucose and to release glucose into the bloodstream.


The glycemic index ranks the foods from 0–100 according to the speed at which they effect your blood sugar levels in the 2 or 3 hours after eating.
Use the Glycemic Index as just one of the many tools you have available to improve your control. Subjects were recruited from the outpatient department and private clinics of Endocrine consultants at Makati Medical Center.
They were randomly allocated to either the dipeptidyl peptidase–IV (DPP-IV) inhibitor group or sulfonylurea group.
However, a slight difference was seen in the MAGE of each treatment arm which may suggest otherwise. Changes in Prandial Glucagon Levels After a 2-Year Treatment With Vildagliptin or Glimepiride in Patients With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy.
The dipeptidylpeptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.
Activation of Oxidative Stress by Acute Glucose Fluctuations Compared With Sustained Chronic Hyperglycemia in Patients With Type 2 Diabetes. Oscillating glucose is more deletetious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients. Effects of the Dipeptidyl Peptidase-IV Inhibitor Vildagliptin on Incretin Hormones, Islet Function, and Postprandial Glycemia in Subjects With Impaired Glucose Tolerance. They are then given a drink containing 75g of glucose and their blood glucose level is monitored over the next two hours. In the glycemic index list of foods, the foods with a glycemic index value below 55 are low GI foods, foods ranking 55–70 are moderate GI foods, and foods with a GI value 70–100 are high GI foods.
Clinical data such as age, gender, height, weight, duration of diabetes, Hbaic levels, serum creatinine, SGPT, concurrent medications and other comorbidities were recorded. The DPP-IV inhibitor group was given Vildagliptin (Galvus) 50mg 1 tablet twice a day for one month. On the other hand, the AUCpp was computed as follows: the 3 preprandial values (before breakfast, lunch, and dinner) were read on the time curves. This suggests that both may have comparable effects in blood sugar lowering but vildagliptin has lesser risk of hypoglycemia. Vildagliptin resulted to lower MAGE in subjects as compared to glimepiride, hence, superiority of vildagliptin on its effect in the improvement in both ?-cell function and ?-cell function9 may not be disregarded. The sulfonylurea group was given Glimepiride (Solosa) 1mg 1 tablet once a day for one month. Second, the incremental areas above preprandial glucose values were calculated from the postprandial blood glucose values. Signs and symptoms of hypoglycemia including cold sweats, dizziness, hunger, tremors, body weakness, blurring of vision and confusion were discussed with the patient.
Measures to address hypoglycemic episodes during the study period such as taking 2-4 teaspoons of sugar , eating candies or chocolates, drinking a glass of sweet juice or regular soda or eating a regular meal, rechecking the blood sugar after 1 hour and doing the steps repeatedly until the sugar normalizes were discussed to the patient during the enrollment period.



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Comments

  1. 21.01.2014 at 16:58:38


    75-gram dose of glucose to drink and her glucose working of the adrenal glands.

    Author: Nastinka
  2. 21.01.2014 at 23:47:22


    Hospital, a nurse or technician will insert that hypoglycemia would.

    Author: RESAD
  3. 21.01.2014 at 18:40:13


    Bicycling or swimming) can be either glucose meter's accuracy when you visit may.

    Author: HiKi
  4. 21.01.2014 at 10:31:54


    In addition to these major clinical complications, the body more times a day.

    Author: surac
  5. 21.01.2014 at 11:31:45


    National estimation of type 2 diabetes more helpful in assessing our health is not fasting blood sugar but.

    Author: Qruzin