Chronic stress, where stress levels remain high for an extended period of time, put us at the greatest risk of developing these physical symptoms and, according to the Center for Studies on Human Stress, it is many of these physical effects which can cause us the most physical damage (such as risk of heart attack and diabetes) over time.
Statin drugs lower LDL and total cholesterol, but have only a modest effect on boosting artery-cleansing HDL. Physicians often rely solely on high-dose statin drug therapy to achieve desired blood lipid readings.
While you should take all necessary steps to protect heart health—which may include cholesterol-lowering medications—high-dose statins are often unnecessary. The encouraging news is that safe, low-cost, broad-spectrum interventions exist right now, especially for individuals with elevated cholesterol, LDL, and triglyceride levels (and low HDL) who do not have other risk factors for vascular disease. Here we will explore a novel set of natural lipid-lowering compounds shown to support healthy cholesterol levels.
A substantial body of supportive research further indicates that monacolin-K also reduces triglycerides and boosts HDL, thus offering a safer and broader spectrum alternative to taking synthetic prescription statins.
You will also discover the clinically demonstrated heart-protective benefits of other natural compounds that can bring your blood lipids into healthy balance, lower C-reactive protein (CRP) in the blood, quell chronic system-wide inflammation, and support healthy endothelial function.
Red yeast rice (RYR), a staple of Chinese medicine and a traditional Asian seasoning, is made by fermenting polished rice with various strains of the yeast monacus purpureus. Monacolin-K effectively lowers cholesterol by acting as an HMG-CoA reductase inhibitor—the same mode of action of synthetic statin drugs. Mainstream medicine has been slow to embrace red yeast rice (RYR) as an alternative treatment therapy because the FDA does not regulate the supplement—and because many doctors remain unaware of its lipid-lowering ability and safety profile.
In one of the largest studies of its kind, a meta-analysis of 93 randomized controlled trials involving almost 10,000 Chinese patients found that RYR could significantly lower levels of total cholesterol, LDL, and triglycerides, and raise levels of HDL, compared with placebo.
In a study specifically designed to determine if RYR could lower lipid levels without causing myalgia’s (muscle pain – a common side effect of statins), researchers conducted a randomized, double-blind, placebo-controlled trial in patients with high cholesterol.
While protecting heart health is an important lifelong habit, the long-term effects of high-dose statin drugs carry considerable risks and should not be taken without thoughtful consideration. Safe, low-cost interventions are available now for those seeking to safeguard heart health. Red yeast rice contains monacolin-K, which works by the same mechanism as statin drugs to lower cholesterol. Red yeast rice has been shown to lower LDL, total cholesterol, and triglycerides while raising HDL. Since red yeast rice works similarly to statin drugs, practitioners recommend consuming extra CoQ10 while using it. Other therapies that support healthy cholesterol levels include beta-sitosterol, pantethine, policosanol, and niacin. RYR has been shown in some studies to perform as well or better than some widely used synthetic statins. The alternative treatment included lifestyle changes and ingestion of RYR and fish oil supplements for 12 weeks; the statin group received their medication and traditional counseling. Individuals already suffering from coronary heart disease (CHD) may also benefit from RYR as it has been shown to blunt the increase in triglycerides following a meal in patients with clinically documented coronary heart disease (CHD).
Pantethine is the active form of vitamin B5 (or pantothenic acid), the molecule used to make coenzyme A (CoA). Using prescription statins is not without serious health risks and no one knows the long-term effects of living on them for life, which is how they must be taken. In another illustrative clinical trial, researchers examined the effect of oral treatment with pantethine on 20 patients with elevated cholesterol and triglycerides. A meta-analysis of 14 randomized controlled trials investigated the effects of plant sterols added to margarine on cholesterol levels.  The sterol-fortified margarine caused a reduction in the mean concentration of LDL, an effect that tended to increase with age. The results of two older beta-sitosterol studies further indicate it can decrease systemic inflammation. Some research suggests that policosanol is effective in lowering cholesterol in patients with progressive atherosclerosis and diabetes.
Niacin’s ability to lower LDL, raise HDL, and lower triglyceride levels has been conclusively established by a wealth of clinical research. It is one of the best-known and most widely used vitamins for lowering blood cholesterol levels.
Recent studies further indicate that niacin reduces oxidative stress and inhibits vascular inflammatory genes, including key cytokines involved in atherosclerosis.
Statin drugs are heavily used and over-prescribed, owing to industry influence and misinformation. Chronic exposure to cadmium, which primarily occurs through diet and smoking, damages the kidneys, weakens bones, and may increase cancer risk. The study used data collected from more than 1,600 pregnant women participating in the Maternal and Infant Nutrition Interventions, a food and micronutrient supplementation trial in Matlab, Bangladesh. Average adult daily intakes of cadmium were estimated on the basis of rice consumption to be 25–35 µg, similar to those in other Asian countries where rice is a staple but higher than levels reported in U.S. Cadmium may affect fetal growth by several mechanisms, including impaired nutrient transport and endocrine disruption. The main strengths of the study are its prospective design, large number of participants, wide range of exposure, and consideration of numerous confounding factors. Asian diets high in rice consumption may lead to elevated cadmium intake, which has been linked to reduced birth size in girls.


EHP is pleased to present the abstracts from the 28th annual meeting of the International Society for Environmental Epidemiology (ISEE), held in Rome, Italy, 1–4 September 2016, and hosted by the Department of Epidemiology Lazio Regional Health Service, ASL Roma 1, and the Italian Epidemiological Association.
For a number of years, EHP has posted accepted manuscripts online as what we termed Advance Publications.
DisclaimerPublication of articles in EHP does not mean that the National Institute of Environmental Health Sciences (NIEHS) condones, endorses, approves, or recommends the use of any products, services, materials, methodology, or policies stated therein. Order today using our 100% secure server and get it at the lowest prices in the world with our fast, inexpensive 2-3 day shipping!
Warnings: Consult your physician prior to using this product if you are pregnant, nursing, taking medication or have a medical condition. Reducing your stress, and managing your stress, is then essential not just to emotional well-being, but also to your physical health. One problem with this approach is that side effects elevate markedly as the dose of the statin drug is increased.
They should not be considered the only approach, given their considerable risks at high doses.
Monacolin-K, a compound found in standardized red yeast rice extract, is a naturally occurring statin. It’s no exaggeration to say that statins have become the new aspirin in mainstream medicine’s war on cardiovascular disease. Not content with letting doctors decide whether or not to prescribe statins on the merits of questionably favorable research data, some drug companies have apparently taken to bribing physicians to push statins on their patients.
Bioactive compounds found in RYR complement monacolin-K’s lipid-lowering effects, including unsaturated fats. This constitutes a great disservice to the millions of Americans now taking synthetic statin drugs. Study participants were randomly assigned to take either 1,800 mg of red yeast rice or placebo twice daily for 24 weeks.
Red yeast rice has even benefitted individuals who could not tolerate the side effects of statin drugs. The RYR treatment achieved these results without increasing muscle pain or CPK (creatine phosphokinase)—an enzyme in the blood that indicates muscle damage. After a high-fat meal, RYR significantly reduced fasting serum lipids while increasing fasting HDL. CoA is involved in the transport, synthesis, and oxidation of fatty acids to and from the cells, and into the mitochondria.
People who use them and then quit a year later face elevated risk levels of stroke and heart attack.
They found significant decreases of total cholesterol, LDL, and triglycerides, with increased levels of HDL.
This class of compounds is molecularly similar to cholesterol and may inhibit cholesterol’s absorption in the lower intestine and reduce levels of cholesterol in the blood. In one meta-analysis, the lead investigator noted that beta-sitosterol appears to support proliferation of peripheral blood lymphocytes and enhance the cytotoxic effect of natural killer cells. One study found that pretreatment with policosanol and omega-3 fatty acids prevented arterial wall thickening and endothelial damage in animals whose arteries had been damaged artificially. One study tested policosanol in patients suffering ischemic stroke who were also treated with aspirin and vitamins.
It has also been shown in multiple studies to provide better heart health protection than some statins. Use it only under the guidance and supervision of your doctor or a healthcare practitioner.
Until recently, niacin’s general use and widespread patient tolerability have been impeded by the need to take it 4 times a day and by the high incidence of skin flushing, gastric problems, and other adverse events. High-dose statins are often unnecessary, and may not be the right choice for millions of people, given their side effect profile.
Barrett, MS, ELS, a Madison, WI–based science writer and editor, has written for EHP since 1996.
The metal is also an endocrine disrupter and may adversely affect reproduction and child development. Sex-based differences in specific hormone levels as well as in cadmium uptake and mechanisms of action—which have been reported in experimental studies—may have played a role in the current findings. However, the potential for unmeasured or residual confounding remained, as in all observational studies, and infants’ cadmium exposure was not directly assessed (for instance, by measuring cadmium levels in cord blood).
The focus of this year’s conference is current and future challenges in exposure assessment, study design, and data analyses. The concept here was simple—to get the content online as quickly as possible in an effort both to get authors the attention they deserve and to get readers the information they need.
Conclusions and opinions are those of the individual authors and advertisers only and do not reflect the policies or views of the NIEHS. These are usually fairly minor stress indicators, you might be running late to meet a friend, studying for an exam, trying to get your kids to school or responding to a particularly busy workplace scenario. The side effects of sustained statin use are well documented—muscle wasting, cognitive impairment, blurred vision, and nerve damage, among others.


It may surprise you to learn that in clinical studies, red yeast rice along with healthy lifestyle practices lowers cholesterol as effectively as the prescription drug simvastatin. A 2009 investigative report disclosed that Pfizer and AstraZeneca, pharmaceutical giants that make the two best-selling statins—Lipitor® and Crestor®, respectively—offered Canadian doctors $100 for every new patient they put on the cholesterol-lowering drugs. There is a wealth of compelling evidence indicating RYR’s power to lower low-density lipoprotein (LDL) and triglyceride levels and raise high-density lipoprotein (HDL)—without unwanted and sometimes dangerous side effects. All participants were also enrolled in a 12-week therapeutic lifestyle change program during the study.
But the AT group also achieved significant reductions in triglycerides (–29% in the AT group vs. Post-meal triglyceride levels fell by 43% after 6 hours in the treatment group—but not in the control group. As a member of the B-complex family of vitamins, pantothenic acid is essential to numerous bodily functions, including synthesis of neurotransmitters, hormones, and hemoglobin. Many people who take statins have to stop because of muscle pain, the most commonly reported side effect. Phytosterols have also been shown to act in synergy with red yeast rice by achieving a therapeutic effect at a lower dose. In a 2005 study, researchers gave 29 individuals with high cholesterol (40-80 years old, average age = 55; 14 with type 2 diabetes) an edible beta-sitosterol spread.
Another study that measured inflammation and immune suppression in marathon runners found that beta-sitosterol could help prevent immune system suppression and could reduce bodily inflammation.
They achieved substantially positive results, with improvements in neurological outcomes and recurrent events. A widely publicized study appearing last November in the New England Journal of Medicine found that niacin was more effective at shrinking artery plaque than a billion-dollar blockbuster called ezetimibe, the active ingredient in the cholesterol drugs Zetia® and Vytorin®.
It is metabolized in the body into its component parts, niacin and inositol, and does not reach maximum blood levels for approximately 10 hours after ingestion.
Studies indicate that any reduced cardiovascular risk from taking statins may be offset by other serious side effects, from sexual, visual, hepatic, renal, and cognitive dysfunction to disability and death.
She is a member of the National Association of Science Writers and the Board of Editors in the Life Sciences. Animal studies indicate cadmium induces multiple defects in developing embryos, but it is unknown whether similar effects occur in humans. Information on demographics and tobacco and betel use during pregnancy also was collected, along with newborns’ sex and physical measurements.
The authors say the estimated average reductions in head circumference and weight are unlikely to be clinically significant for individual children but could have public health implications given widespread dietary cadmium exposure and adverse effects associated with reduced birth size.
Continuing research should follow the children to determine if growth effects are sustained through childhood and whether other health changes appear later in childhood. Immediately discontinue use and contact your healthcare professional if you experience any adverse reactions to this product.
Studies have shown that pantethine can reduce serum triglycerides and cholesterol levels while increasing HDL levels. Both diabetic and non-diabetic patients experienced a greater reduction in LDL—27% and 15% respectively—than controls.
Together, these anti-inflammatory properties led researchers to suggest that beta-sitosterol might be of clinical use in treating a number of chronic inflammatory conditions that could lead to cancers of the breast and colon. PrimeMD recommends taking additional CoQ10 for those people who take statins and red yeast rice-containing products.
This form of the vitamin has not been linked with the skin “flushing” or other typical niacin reactions, even when ingested in amounts typically associated with skin flushing, nausea, vomiting, and agitation.
Aging individuals who want to lower their blood lipid levels and C-reactive protein (CRP) number may be able to achieve similar benefits with standardized red yeast rice extract, beta-sitosterol, pantethine, policosanol, and niacin.
Made in a GMP facility on equipment that processes dairy, soy, eggs, peanuts, tree nuts, fish, shellfish and wheat. You may have lost your job and be struggling financially, you or someone you love might be suffering from an illness, or your child might be the victim of bullying behaviour. In 2003, when AstraZeneca was poised to launch Crestor®, which was already known to have twice the adverse side effects of other statins, another unethical deceit was discovered. These denials occur even when patients present with symptoms that are well-documented adverse reactions to statin drugs, such as muscle pain and detrimental changes in memory, concentration, and mood. Regrettably, it also does not work as well as niacin in reducing LDL and triglycerides and boosting HDL.
These synergistic ingredients have been shown to reduce blood lipid levels while promoting healthy endothelial function and reducing CRP and systemic inflammation. Bryan Brewer, a highly influential cholesterol researcher, raved about the drug, telling attendants at a seminar at an American Health Association convention that the drug was safe and effective. His comments were conveniently published in a “special supplement” of the American Journal of Cardiology, timed perfectly with the release of Crestor® to the US market.



Sample of blood sugar chart
High blood sugar treatment at home naturally
Glucose sugar test results yesterday
Lab test for blood sugar levels vary


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