High blood glucose (called hyperglycemia by medical professionals) is the defining characteristic of all types of diabetes. Signs and symptoms of high blood glucose are often what lead people with undiagnosed diabetes to visit their doctors and, consequently, get diagnosed. The dehydrating effect of polyuria is a key player in many of the other signs and symptoms of high blood glucose, including polydipsia. The relationship between excessive urination and excessive thirst is often misinterpreted by people experiencing high blood glucose, especially before diabetes is diagnosed. Complicating matters, many people reach for a soda when they’re thirsty, and most sodas contain both some form of sugar and caffeine.
If cells aren’t able to gain access to glucose, they send out hunger signals via a variety of signaling hormones, including leptin, ghrelin, orexin, and PYY 3-36.
First, the loss of fluids from excessive urination can lead to a low level of body fluids, which can make you weigh less.
Second, if insulin levels are too low for glucose metabolism, your body will switch to burning fat to maintain cellular metabolism, and burning fat can lead to weight loss (just what you’re trying to do at the gym, right?). Teenage girls with Type 1 diabetes have been known to manipulate this biological phenomenon via an eating disorder called diabulimia. Urinary tract infections (UTIs) and yeast infections can occur in both men and women, but they are much more common among women, and they’re particularly common among women with diabetes. UTIs, on the other hand, are quite a bit more complicated, and high blood glucose contributes to them in several ways beyond providing glucose-rich urine for the bacteria to grow in. In addition, elevated glucose reduces blood circulation, which in turn reduces the ability of infection-fighting leukocytes (white blood cells) to get where they are needed in a timely manner in sufficient numbers to fight off infections.
High blood glucose greatly slows the healing of skin and soft-tissue infections because neutrophils, the most common type of leukocyte in the immune system’s arsenal, are particularly vulnerable to high levels of glucose. Another critical element of wound healing is a sufficient supply of oxygen, and the delivery of oxygen can be reduced by either peripheral neuropathy (nerve damage) or peripheral vascular disease (blood vessel disease) – both common conditions caused by or made worse by high blood glucose. A less dangerous but highly vexing and common side effect of high blood glucose is dry, itchy skin. Last but not least, nerve damage can interfere with the normal operation of sweat glands, affecting one of skin’s natural moisturizers and leading to dry skin. Speaking of dryness, blurry vision from acute high blood glucose is also a result of the dehydrating effect of excessive urination. Chronic high blood glucose, on the other hand, can lead to retinopathy, or damage to the back of the eye that can affect vision and ultimately even lead to blindness.
Acute hyperglycemia can cause headaches and difficulty concentrating in a fashion similar to polyphagia – in which starving cells send out hunger signals because they can’t access the glucose circulating in the blood. When your blood glucose is high, your body is neither storing nor utilizing glucose properly. In fact, nearly all the signs and symptoms of high blood glucose can contribute to making you feel fatigued, even exhausted. Both constipation and diarrhea can be caused by high blood glucose, acting on different sections of the bowel. The two intestines have very different jobs, which helps to explain how high blood glucose can affect them differently.
When neuropathy from elevated blood glucose affects the enteric nerves – the gut’s command and control system – in the small intestine, the result can be dysfunctions in motility, leading to delayed emptying into the large intestine.
Constipation can also be caused or made worse by the dehydrating effects of excessive urination and by some medicines, especially narcotic pain killers, some antidepressants, and the calcium channel blocker class of high blood pressure medicines. Erectile dysfunction, or difficulty maintaining an erection, is a common side effect of high blood glucose, and roughly half of men with diabetes over the age of 50 experience it. A healthy erection requires healthy nerves, healthy blood flow, the right balance of hormones, and sexual stimulation. High blood glucose can adversely affect erections in three ways: hormonal, vascular, and neurologic. Making matters worse, there are a number of common medicines that can contribute to or worsen erectile dysfunction. High blood pressure can also contribute to erectile dysfunction, as can a build-up of low-density lipoprotein (LDL) cholesterol in the corpora cavernosa supply arteries.
The good news is that the drugs Viagra (sildenafil), Cialis (tadalafil), and Levitra (vardenafil) can all help counteract the loss of nitric oxide, helping the blood vessels dilate, and increasing blood flow to the penis. But when you consider all the other biological manifestations of high blood glucose – the three polys, infections, slow healing of injuries, itchy skin, blurred vision, headaches, fatigue, and gastro-intestinal distress – is it any wonder we might be irritable?
While the causes that lie behind the symptoms of high blood glucose are fascinating, the real value of symptoms is in the message they carry: Blood glucose is too high. But you have it in your power to make the symptoms go away, and to keep them from coming back, by keeping your blood glucose in control. Wil Dubois BS, AAS, CPT, is a diabetes columnist and author of four books about diabetes that have collectively won 14 national and international book awards. Disclaimer Statements: Statements and opinions expressed on this Web site are those of the authors and not necessarily those of the publishers or advertisers. It’s clear that uncontrolled diabetes can increase the risk of hypertension (high blood pressure).
The treatment of diabetes itself is more focused to control the level of blood glucose, particularly to make sure that it doesn’t increase too high (higher than normal). While it can be helpful to provide adequate insulin for blood sugar control, but sometime it also can lead to hypoglycemia particularly if taken improperly.
It is the force or pressure that occurs between blood that flow through the blood vessels and the wall of blood vessel itself.
Uncontrolled hypertension can cause damage to the blood vessel itself which then can cause some serious health conditions, such as stroke, heart failure problem, etc. Seizures can be triggered by too low blood sugar (hypoglycemia) and maybe by too high blood sugar (hyperglycemia).
To control the movement of your body, your brain needs to send some small electrical signals around the body. Problems that damage to the brain such as an injury of head, brain tumor, brain surgery, and stroke. In addition – an extremely fiver (especially if it occurs rapidly) and withdrawals of illegal drugs, certain prescription medications, or even abusing alcohol may also trigger  and cause seizure. It is clear that hypoglycemia or too low blood sugar can be a trigger factor of seizure – as noted before. In fact, fatigue & tired feeling are pretty common in people with hyperglycemia or high blood sugar. The performance of your glucose metabolism is closely associated with the fluctuation of your blood sugar. Your pancreas is the major organ that produces insulin and releases it into the bloodstream.
The symptoms of tired feeling, weakness, and fatigue are usually caused by the lack of energy supply for your body. When the glucose in the blood is poorly absorbed or even cannot be properly absorbed by your muscles or cells of your body as it should be, your blood sugar is easier to rise and you cannot get adequate amount of energy that meet to your body needs.
Even high blood glucose also can be potential tocause unusual weight loss – if there is poor energy converted from glucose, then there is also no excess energy to be stored as fat in your fat cells. Lack of physical activity – if you are physically inactive, you are relative easier to have hyperglycemia than others who keep active. This “juicing will cure you of EVERYTHING” myth is one of the most DANGEROUS myths of this 21st Century!!!!

How does high blood glucose cause frequent urination, make your vision go blurry, or cause all of those other things to happen?
It happens when the body can no longer maintain a normal blood glucose level, either because the pancreas is no longer making enough insulin, or because the body’s cells have become so resistant to insulin that the pancreas cannot keep up, and glucose is accumulating in the bloodstream rather than being moved into the cells. But each sign or symptom has a biological underpinning, or a specific cause behind the effect. Acute hyperglycemia lasts only briefly and is often the result of a high-carbohydrate meal, a missed dose of medicine, stress, or illness.
But signs and symptoms of high blood glucose can also occur after diabetes is diagnosed and treatment has been started. Polyuria is the result of a runaway biological and chemical chain reaction that feeds on itself.
Normally, the kidneys serve as filters, removing waste products and returning cleansed fluid back to the body. The cells are pumping water into the bloodstream, and the kidneys, unable to reabsorb this fluid during filtering, are uncontrollably flushing water from the body. In rare cases, polyuria can top out at 20—25 liters per day, about half the body’s total fluid volume. Many people assume that excessive urination is caused by the excessive thirst, and not the other way around. The sugar raises the blood glucose level even higher, and the caffeine, a diuretic, makes the polyuria worse. Excessive hunger isn’t really caused so much by a high blood glucose level as by a low insulin level. All of these hormones signal the brain’s hypothalamus to trigger the sensation of hunger. That glucose is full of calories, so when there are high levels of glucose in your urine, you’re literally peeing calories away as your body tries to jettison the excess glucose. They keep their weight low by keeping their blood glucose high, allowing them to eat more food while maintaining a lower body weight.
In fact, women with diabetes are two to three times more likely to have bacteria in their urine than women who don’t have diabetes. Long-term elevated blood glucose can lead to a number of complications, including neuropathy, or damage to nerve tissue, which can affect a wide variety of body systems. High blood glucose also reduces phagocytosis, the process leukocytes use to ingest bacteria. In fact, skin problems on the feet and lower legs are a sign of atherosclerosis – hardening and narrowing of the arteries and its attendant reduction in circulation – a disease all too common in people with diabetes. Unique to people with diabetes, diabetic dermopathy shows up as scaly circular or oval patches of discolored skin that resemble age spots. As you will recall, when the concentration of glucose in the blood is high, the body attempts to dilute the blood by pulling fluid from cells into the bloodstream.
Recent research has shown that by the time of diagnosis, 35% of people with Type 2 diabetes already have some degree of retinopathy. If you don’t believe it, consider that while the brain represents about 2% of your body weight, it devours fully 25% of the glucose you consume. You’re not burning energy efficiently, nor are your cells getting the fuel they need when they need it.
Exhausted people often resort to eating high-carbohydrate snacks for a boost of quick energy, and this, of course, raises the blood glucose level more, making the problem worse rather than better. When high blood glucose affects the small intestine, the result is often diarrhea; when it affects the large intestine, the result is often constipation. The job of the small intestine is to absorb nutrients from digested food, and the job of the large intestine is to absorb water from indigestible waste material. This causes the stagnation of fluids in the small intestine, allowing bacterial overgrowth that causes bloating, abdominal pain, and diarrhea.
Slow-moving waste is essentially dehydrated – or dried out too much – by the large intestine, resulting in constipation. To form an erection, nerve signals cause the blood vessels that supply the corpora cavernosa to dilate, so that blood flow to the chambers increases.
On the hormonal front, high blood glucose interferes with the body’s production of nitric oxide, a so-called vasodilator that triggers the hormonal chain reaction that relaxes the blood vessels and allows the corpora cavernosa to fill with blood.
Many high blood pressure pills, especially those in the families of beta blockers and diuretics, and some antidepressants, can interfere with vasodilation (or the widening of blood vessels).
The mood-altering effects of high blood glucose are well known to the loved ones of persons with diabetes and well documented by research. In essence, the major goal of the treatment is to maintain the blood sugar levels as close to normal as possible.
In general, type-1 is a condition of when the pancreas is much less productive in producing hormone insulin than type-2.
Therefore if compared with type-2, episodes of hypoglycemia is relatively more common in type-1! The high pressure inside your blood vessels means that your heart needs to work harder to pump the blood around the body. But hypertension in diabetics are much more common associated with hyperglycemia – as noted before! For this mechanism, your body is equipped with a lot of nerves – these nerves acts as carrier for those signals. This suggests that the glucose balance in blood that flows into the brain is very important for the brain to keep functioning properly. Hyperglycemia is a condition when the amount of glucose (a simple form of sugar) in the bloodstream is higher than normal. In most healthy people with good glucose metabolism, their blood glucose levels do not fluctuate widely throughout the day.
Without this hormone, your body cannot convert the glucose taken from food that you eat to become energy. When your body notices that the level of glucose in the bloodstream is high (such as after eating), the brain will send a signal to the pancreas to release insulin into the bloodstream.
Some may be stored in your liver as glycogen and in your fat cells as ‘fat’, which both can be converted again into energy when your body needs.
If you have clearly understood the mechanism of glucose metabolism (as written before), now you should be very easy to understand the correlation between these symptoms and high blood sugar! Eating a lot of foods (especially for foods high in carbohydrate and high in saturated fat) can make your insulin work harder in regulating glucose in the blood, because glucose taken from foods that you consume can be absorbed directly by the bloodstream. It is important to maintain and stick with the pattern of your regular meals in order to also maintain and help your insulin to work regularly. WHO KNOWS how many people may have already DIED because they tried to “juice their way to perfect health” only to be KILLED by their skyrocketing BLOOD-SUGAR levels!!!!
Here are some answers to explain what’s going on in your body when you have high blood glucose. Some of the symptoms have a rapid onset, while others require a long period of high blood glucose to set in.
It starts in the blood, where high glucose concentrations osmotically pull intracellular fluid into the bloodstream. The return of the cleansed fluid – or reabsorption of fluid – takes place in the renal tubules, the internal structure of the million or so filtering nephrons in each kidney. Thirst signals in the brain are triggered by osmoreceptors, specialized cells in the hypothalamus that detect the level of plasma osmolality – the level of dehydration of the blood – and create the urge to drink fluids when a person is dehydrated.

The low insulin level can be either an absolute shortage of insulin, as in Type 1 diabetes, or it can be a relative shortage of insulin, as in Type 2 diabetes. If your high blood glucose level is a new development, you previously maintained a stable weight, and you make no change in your eating habits, you’ll lose weight as a consequence of high blood glucose. The cause may simply be a case of supply and demand: More glucose gives yeast more opportunities. Neuropathy can affect the bladder’s ability to contract properly, causing incomplete emptying. The first is excessive urination, which can actually dehydrate you to the point that your skin tissues begin drying out. This is because in most cases, people with Type 2 diabetes have elevated blood glucose levels for an extended period before their diabetes is diagnosed.
Examples include occipital neuropathy, or damage to the optic nerve from elevated glucose levels, and a variety of diabetic mononeuropathies, which can affect specific cranial nerves, peripheral nerves, or nerve roots – all of which can lead to headaches of varying intensities.
For an erection to occur, a number of complicated hydraulic events has to happen that cause the penis to fill with blood, and then keep the blood trapped inside the penis for a time. As the spongy tissue engorges with blood, it collides with an outer sheath of elastic tissue that encases the chambers. On the vascular front, high blood glucose can be incredibly damaging to blood vessels, potentially reducing the ability of the supply arteries to dilate. Since both high blood pressure and depression frequently accompany diabetes, it’s common for men with diabetes to be on one or more of these medicines. Their method of action is on the hormonal and vascular side of the equation, while the cause of erectile dysfunction among men with diabetes is more often traced to nerve damage, which doesn’t respond to these medicines.
But the biological nuts and bolts behind the emotional response aren’t well understood.
High blood glucose does more than trigger biological and chemical processes that make you feel crummy; over time, high blood glucose causes permanent damage to the body. Consult appropriate health-care professionals before taking action based on this information. Even some people with type-1 have pancreas that is not able to make any insulin for blood glucose control. High blood glucose in the bloodstream can be a signal that glucose metabolism does not work as well as should be.
To get a specific amount of energy, glucose taken from food need to be absorbed first by cells and muscles of the body from the bloodstream.
It is often the result of undiagnosed diabetes or of an inadequate diabetes treatment regimen.
This is the body’s attempt to equalize the concentration of glucose in the blood with the concentration in the cells.
In either case, the amount of insulin in the blood is insufficient to move glucose molecules from the bloodstream into the cells, where they can be used as fuel for cellular processes. This ultimately leads to hunger pangs that, perversely, make high blood glucose worse when a person responds by eating. This leaves behind residual pools of static urine in the bladder – the perfect growth culture for bacteria. Tissue necrosis can then extend from the soft tissue into the bone, which is what often leads to amputation: More than 66,000 amputations were performed on persons with diabetes last year. Diabetic dermopathy is not considered dangerous, and there is no treatment for it, but it serves as a visual sign of high blood glucose. When the lens of the eye gets dried out, it becomes temporarily warped, and the eye loses its ability to focus properly.
This is also why the American Diabetes Association recommends that people with Type 2 diabetes have an initial dilated and comprehensive eye exam shortly after diagnosis. This can cause problems with thinking, reasoning, and remembering, difficulty staying focused on tasks, and headaches.
If you are also suffering from a lack of proper sleep due to excessive urination during the night, you will feel even more tired. Enteric neuropathy, in addition to laying the ground work for bacterial overgrowth, can in itself be a painful chronic condition similar to the foot pain suffered by people with peripheral neuropathy. This temporarily chokes off the veins that drain the blood back out of the penis, allowing the erection to stabilize. In a similar fashion, nerve damage from high blood glucose can affect both sensation and nerve signaling involved in the erection process. Also well documented is the fact that high blood glucose causes depression and negatively affects rapid thinking and decision-making skills. Then glucose will be converted into energy and will be used to support your activity throughout the day.
You likely know some of the items on the list by heart: thirst, frequent urination, blurry vision, slow healing of cuts, and more. Chronic hyperglycemia is arguably the more dangerous of the two, as long-term elevated blood glucose has a toxic effect on the body’s tissues. By diluting the blood with intracellular fluid, the body brings the glucose concentration of the blood closer to normal.
Until the glucose levels are normalized, the renal tubules can’t regain the ability to absorb fluids.
So are oranges, grapefruits, apples, potatoes of ANY kind, blackberries, blueberries, cherries, carrots, etc, …because YOUR BODY CANNOT PROCESS THE SUGARS!!!! In fact, some of the signs of high blood glucose are actually the aftermath of cellular damage caused by high blood glucose. Use the tools available to you, such as your blood glucose meter, to see whether your numbers are in target range most of the time.
And JUICING will send exceedingly high levels of sugar ( or fructose ) RIGHT INTO YOUR BLOODSTREAM!!!!!
But with diabetes, your system has very little or even NO ability to get your blood-sugar-levels back to NORMAL again,… nor can it transform the sugars into usable INSULIN!!!!!!
Though I did not consume large amounts of the “sweet stuff” on a daily basis, It added up WAY too fast!!! If Popeye had tardive diabetes, and he had juiced 3 apples, two oranges, and a sugar-beet, he would have needed a lot more that a can of SPINACH to save his ass!!! Though I consumed the “sweet” fruits and veggies is small amounts, they added up ASTRONOMICALLY! I damn near ended up KILLING myself, all the while mistaking my symptoms for,, … DETOX!!!
Friend, I’m going to level with you, here: If you have serious, tardive ( tardive means serious, chronic, potentially LETHAL!
If you fall, the only “net” that may catch you may be the a fast trip to the EMERGENCY ROOM!!! You can ,indeed, get diabetes SO bad that just ONE SLICE OF APPLE can send you blood-sugar SOARING!!!! And if your diabetes is THAT bad, you no doubt require multiple INSULIN INJECTIONS throughout the day!!!!!! I even ate PANCAKES the following morning, and even THEY didn’t hurt me as badly as those FRUIT JUICES did!!!!!!!!!!!!!!!!!

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