Of special note here is that GGT in the upper half of the population range increased the risk of diabetes by 100% in normal BMI ranges, by 150% in the overweight BMI range and by 268% in the obese BMI ranges (after adjusting for several relevant factors). Higher serum GGT levels were positively associated with diabetes mellitus, independent of, alcohol consumption, body mass index, hypertension and other confounders.
According to glucose tolerance test, 153 were normal and 217 and 181 were diabetic and prediabetic respectively. Adjusted odds ratios (ORs) and 95% CIs of newly recognized diabetes (205 cases) by category of BMI and quartiles (Q) of serum GGT.
Supporting this hypothesis, cross-sectional investigation of background exposure to POPs in the National Health and Nutrition Examination Survey showed relationships similar to those observed for GGT, including a powerful association with prevalent diabetes and no association between obesity and diabetes for very low POP concentrations.
The association between BMI and the incidence of DM (diabetes mellitus) was enhanced by increased GGT levels in women. HRs were calculated and adjusted for age, family history of diabetes, smoking habits, baseline glucose type, alcohol consumption and ALT.


After 72h, despite the similarities in triglyceride accumulation, LPON treatment, but not oleate, dramatically affected mitochondrial function as evidenced by decreased respiration, increased mitochondrial membrane potential and ROS formation with concomitant enhanced ketogenesis. Gamma-glutamyltransferase activities of males and persons older than 45 years were significantly higher than each counterpart. Gamma-glutamyltransferase levels increased significantly with the number of cigarettes smoked per day and the frequency of alcohol consumption except for the persons who did not take alcohol.
The investigators concluded, "These findings suggest that a raised serum GGT level is an independent risk factor for NIDDM.
As noted in other more recent studies on this page, the relationship of GGT to diabetes still exists when appropriate adjustments are made for fat.
The more recent studies suggest this relationship is most likely mediated by oxidative stress.
The next article on this page (#18) is a letter to the editor written b by two of the same authors of the editorial (article #2) on our IRON-Diabetes page.


As shown in Table 1 (see below), the concentrations of FPG and triglycerides markedly increased among the GGT categories.
Such individuals might benefit from a more intensive therapeutic approach to decrease their global cardiovascular risk, regardless of potential unmeasured effects of lifestyle or obesity.
Conceivably, the significant association of serum GGT concentrations with FPG and triglycerides, observed in our investigation, may be biologically explained by some underlying mechanisms such as hepatic steatosis, insulin resistance, and increased oxidative stress.
GGT was significantly associated with the 3-year incidence of individual components of the MetS.
The investigators studied the incidence of impaired fasting glucose (IFG) and type 2 diabetes over a seven year period.



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Comments

  1. 29.06.2015 at 13:13:38


    Found to reduce the progression to frank impact of type 2 diabetes may the OGTT test.

    Author: 027
  2. 29.06.2015 at 23:16:57


    They do this using two fast-acting hormones.

    Author: 202
  3. 29.06.2015 at 15:10:33


    And type (low glycaemic index) not.

    Author: LADY