Aim 8: Diabetes is having an increasing effect on human societies around the world, including personal suffering due to ill health from the diabetes directly but also from side-effects such as kidney failure. TOK: The causes of the variation in rates of type II diabetes in different human populations could be analysed.
Why are the organs of the endocrine system seemingly geographically unrelated and unconnected? Aim 7: Data logging using a surface temperature sensor to investigate the warming by nasal passages could be carried out here. In a negative feedback loop, the body detects an internal change and activates mechanisms that reverse, or negate, the change. The counterpart to negative feedback is a positive feedback loop, a process in which the body senses a change and activates mechanisms that accelerate or increase that change.
Back in 2008, I began writing about the effect of dietary fat on insulin sensitivity, and blood levels of glucose and insulin. Over the years I learned that saturated fat decreased insulin sensitivity more than other fats, e.g. One mechanism by which dietary fat decreases insulin sensitivity, raising blood glucose and insulin levels is through reduced action of the glucose transporter GLUT4. Rats fed a high (50% of calories) fat diet for 8 weeks showed 50% decreases in insulin-stimulated glucose transport. Subjects were deprived of dietary fat (via gastric surgery that decreases predominantly fat absorption). Mice that were fed a high-fat diet and that became obese were protected against insulin resistance and the high glucose and insulin levels of their counterparts when they were bred to have more GLUT4.
That reduction in endothelial NO (NO is nitric oxide) production contributes to high blood pressure. This entry was posted in Diabetes, Fat and Oil, Insulin Resistance, Saturated Fat on June 5, 2014 by Bix.
Scott Cousland I have never seen mainsteam science ever attribute the root cause of disease to the correct source: emotional trauma Dr.

Fanatic Cook by Bix is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Diabetes – how to normalize your blood sugar, Are you diabetic, or are at risk for diabetes? How to lower your blood sugar fast – hubpages, If your high blood sugar level does not come down within an hour of the above temporary measures and is accompanied by any of the following symptoms, seek emergency. The insulin transduction pathway is an important biochemical pathway beginning at the cellular level affecting homeostasis. The functioning of a signal transduction pathway is based on extra-cellular signaling that in turn creates a response which causes other subsequent responses, hence creating a chain reaction, or cascade. Rates can be particularly high when individuals consume a diet very different to the traditional one of their ancestors, for example, when having migrated to a new country. Nerve impulses are measured in millivolts; but a dynamite fuse is a better analogy for an axon nerve than an electrical wire. The resting potential (-70mV) is caused by a chemical concentration gradient established by pumping Na+ and K+ ions selectively across the axon membrane. The action potential (+40mV) is the dramatic reversal (and subsequent restoration) of the resting potential.
There is a refractory period as concentration gradients of Na+ and K+ ions are restored by active transport.
Protein hormones bind to receptors in the membrane, which causes the release of a secondary messenger inside the cell. This can also aid homeostasis, but in many cases it produces the opposite effect and can be life-threatening.
There seems to be both a reduced expression of the GLUT4 gene, and a reduced translocation or movement of GLUT4 to the cell membrane in the presence of a high-fat, especially high-saturated fat diet.  (GLUT4 is one of the glucose transport proteins that move glucose from the bloodstream into muscle and fat cells. When normal amounts of insulin fail to clear blood of glucose, the pancreas responds by releasing more. Also, the fat we eat can change the composition of lipid in cell membranes.  A diet high in saturated fat has been shown to make membranes less fluid and may impair GLUT4 insertion.

There really is abundant research on the role of dietary fat in the development of insulin resistance, a condition which manifests as elevated glucose, elevated insulin, and the development of type 2 diabetes. This pathway is also influenced by fed versus fasting states, stress levels, and a variety of other hormones. During the course of signaling, the cell uses each response for accomplishing some kind of a purpose along the way. This is primarily due to carbohydrate intake, but to much lesser degree protein intake Depending on the tissue type, the glucose enters the cell through facilitated or passive diffusion. There are genetic differences in our capacity to cope with high levels of refined sugar and fat in the diet. This depolarization depends on the sudden, localized opening of gated channels in the axon membrane, allowing N+ ions to rush into the interior. The result is impaired glucose tolerance, hyperinsulinemia, and eventual development of type 2 diabetes. About 5 years ago I bought a dehydrator (not expensive) and so have dried lots of veggies myself. When carbohydrates are consumed, digested, and absorbed the pancreas senses the subsequent rise in blood glucose concentration and releases insulin to promote a uptake of glucose from the blood stream. In muscle and adipose tissue, glucose enters through GLUT 4 receptors via facilitated diffusion.In brain, kidney and retina, glucose enters passively.
Squeezing the trigger of a gun very gently or aggressively has no influence on the speed of the bullet. Over time, compensatory insulin output from beta cells in the pancreas diminishes and a person with type 2 diabetes may find themselves injecting insulin instead of just taking oral meds. When insulin binds on the cellular insulin receptor, it leads to a cascade of cellular processes that promote the usage or, in some cases, the storage of glucose in the cell.

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