The horse Insulin hormone is the key hormone to get tested, but if you are concerned enough to test, also check the Glucose, total T4 and the ACTH (if suspect Cushings).
Special tubes are required and special handling of the blood is needed for accurate numbers. Keep your horse as calm as possible – maintain routine – you know the best ways to do that – a rodeo to catch the horse will falsely elevate hormones. Fevers, current Laminitis is enough stress to elevate Insulin and ACTH, so we struggle to tell if high numbers are true or if the numbers are up from sickness.
ACTH hormones in horses can jump seasonally from late July to November (peak August, Early September). A recent university study shows that all horses over 13 years old had enlargement (Hyperplasia) of the Pituitary but some had higher ACTH and some were normal.
New, standard way to test horses with Equine Insulin Resistance: Oral Glucose-Insulin Response Test – What the best and most accurate. Dynamic testing is “direct measures of the cellular sensitivity and are considered to be the Gold Standard for diagnostic purposes.” Rutgers University, 2011. Do all you can to keep your horse calm and relaxed the night before and morning of the test.
Some mares do struggle to maintain foals if they go into pregnancy already having Equine Insulin Resistance. We need to eliminate variables in the grain, how fast or slow the horse eats it, types of different items in the grain influencing results, and exercise’s influence on metabolism and the effects of different grain on exercise effects. This allows us to draw only one blood test instead of pre- and post- (2 samples = 2 times the cost) samples, and, there is no passing the stomach tube required, which would involve another veterinary fee. No IV drips of Glucose are needed and no 6-8 blood tests every 15 minutes for hours on end – saves time and expense.
Safe Karo Syrup Oral Glucose Challenges on dozens of horses and ponies at three different veterinary schools in the United States have not had one problem with the product – no Laminitis in any horse. Once spun, serum or plasma is transferred to a plastic tube using a sterile syringe and needle or sterile pipette.
The samples can be frozen prior to shipping (required if ACTH being tested also) or refrigerated prior. Send samples only to labs that test Insulin dozens of times a week and with Board-Certified Clinical Pathologists on staff. Horses and humans both peak in Insulin at the same time, after meals and after a Glucose Challenge.
Horse Insulin – these lab ranges on test results, are for fasting horses or horses not being challenged and on hay. Glucose – with Karo Syrup Challenge, blood sugar (Glucose) will peak in the upper levels of normal lab numbers for normal horses and some early stage Insulin Resistant horses.
Glucose is affected not only by Insulin Resistance, but other times such as Cushings and fever. Remember, that in day-to-day life of a horse with Equine Insulin Resistance, their Glucose is normal. B.  Equine MIRG and Equine RISQI is not to be used in determining Equine Insulin Resistance in individual horses. C.  Equine MIRG or Equine RISQI is not used to determine Equine Insulin Resistance in Veterinary School Hospitals or Laminitis Conferences.
After 60 days on the HEIRO Program, using the supplement and feed program, retest your horse’s blood, again using the Karo Syrup for the Glucose-Insulin Response Test.
This all-in-one blood monitor and syringe allows diabetics to monitor their blood glucose level and take an appropriate dose of insulin with the pen.
People are most familiar with the three major cells in blood: red blood cells, white blood cell and platelets. 92% of plasma is made up of water mixed with a number of important substances and nutrients such as hormones, immunoglobulins, lipoproteins, mineral ions, and gases. Research has shown that green tea can help prevent the peroxidation of lipids and the rupturing of red blood cells. Although cholesterol is one of the essential substances necessary for the normal function of a human body, excessive level of cholesterol, or more precisely, excessive level of LDL may have a severe impact on blood vessels and eventually on human health. Green tea has been shown to be beneficial by lowering blood choleterol levels, including total cholesterol and further decrease of LDL levels. Diabetes is a condition of having too much sugar in blood, which may be due to a lack of insulin or problems with insulin sensitivity. Lack of physical activity and obesity are the biggest causes of diabetes in that they may lead to insulin resistance and an eventual lack of insulin production in the long run. Many studies show that drinking green tea increases the sensitivity of insulin, which means our bodies can recognize insulin better. High blood pressure, which may be due to excessive levels of cholesterol and sugar and other related factors, is considered as one of the major risk factors of developing cardiovascular diseases such as a heart attack and stroke.
Long-term untreated high blood pressure may damage blood vessels and eventually damage organs such as the kidney, stomach and intestines.


A lifestyle of regular green tea consumption has been associated with lowering blood pressure. Another cause of adult diabetes is when a person’s body produces defective insulin (although this is not a typical cause of adult onset diabetes).  A third cause for diabetes and hyperglycaemia in adults is the inefficient use of insulin in the body. Diabetes affects mainly the cells of fatty and muscle tissues and can develop into what is referred to as “insulin resistance”. Type 1 diabetes is brought on by a lack of insulin in the body, which is normally secondary to a process that destroys the effective insulin-producing cells in your pancreas. If you are resistant to insulin, your body can increase the insulin production, to overcome the resistance level. Even when you haven’t eaten, your body will normally release insulin into your bloodstream to maintain the glucose at a steady level. Butch is a guest blogger whose interest in mechanics extends past the human body to the more straightforward mechanics of the automobile. Research is showing that Cushings may be occurring earlier and earlier in horses due to high Insulin damaging Pituitary cells. Poor handling in any step will yield false numbers and that leads to your horse not getting the correct therapy.
We have seen, in our practice, 200 point drops in ACTH in less than one week, just by providing comfort to the feet.
This is a big problem in a thin horse because the unneeded Thyroid powder will cut even more weight off. This makes testing during this time challenging – is it up due to season or due to Cushings?
If your horse has Insulin Resistance, the Dexamethasone could trigger Laminitis – you need to know that fact. If your horse is Insulin Resistant as a youngster, test for ACTH as it gets older, and especially after 13 years old.
What this hormone does in Insulin Resistance, Cushings, older horses, sick horses, painful horses at this time is in the investigation stage. The Vet had an emergency and I did the Karo squirt at 8:00 AM and they cannot get here until noon – what now? If your mare is Insulin Resistant, test her Insulin prior to cover and starting at 8 months into pregnancy and at month 9, 10, and 11. It is easy to get, economic, done in 10 seconds, easy to do, repeatable to see progress, one bottle does many horses, a standardized test to compare horses in your backyard and to horses a thousand miles away. Many horses only on hay, or fasted, or tested in the afternoon had Insulins under 40 uml, and was called normal, even though cresty, Laminitic easy keepers. Old tubes do NOT draw in the right amount of blood due to the seal of rubber at the top dies out, so air gets into the tube and the vacuum is less. This slows the cells from metabolizing Glucose and from Insulin, Thyroid and ACTH levels from dropping (creating a false low number). This is when Insulin peaks in horses – approximately triples from resting and peaks at this time.
Most Insulin Resistant horses will have Glucose levels above normal and some will have sky high Glucose numbers (over double maximum of the normal range). This is the standard now used in Veterinary schools, Laminitis meetings, and used in human medicine for over a decade. Each component plays a significant role in the human body, but one must understand that the other half of blood (55%) is composed of plasma.
While each component of the blood has its own role, the role of the blood itself is to circulate through out the body as it carries various components to proper locations of the body. Notable compounds include catechins, theanine, vitamins, essential oil, minerals and caffeine. These studies examined the antioxidants in the blood, the evidence of lipid peroxidation, and changes in the membrane of red blood cells caused by oxidation in order to see how green tea might affect the oxidation of blood plasma and red blood cells. The oxidation of LDL particles can cause the formation of atherosclerotic lesions, which is the thickening of artery walls caused by the accumulation of fatty materials under the blood vessel wall.
In addition, drinking green tea has been shown to lower glucose production in the liver and decrease glucose absorption in the intestines.
Catechins in green tea have been shown to dilate and relax the blood vessels, which can lower blood pressure. Symptoms include blurry vision, excessive thirst, fatigue, frequent urination, hunger and weight loss. Type 2 diabetes often shows a steady rate of decline of beta cells, and this adds to elevated blood sugar. After a time, if your production eventually decreases, and there isn’t as vigorous a release of insulin, you may develop hyperglycaemia. Besides helping glucose to enter your cells, insulin also regulates tightly the blood level of glucose.
In the average person this aids in keeping glucose levels in the blood within a controlled range.


He shows his love for his car manufacturer by buying Nissan merchandise and pimping his car up with Nissan QashQai Accessories. Also, ACTH at high levels interferes with the Insulin function leading to high Insulin resulting in Equine Insulin Resistance.
Your Vet can work with you and may still want to test ACTH to see if the medication has any effect.
It is unknown how it effects levels of hormones in a variety of different conditions, but it will be interesting to see how studies develop.
In the study, Insulin peaked at late gestation (pregnancy) and dropped as foals were born and started to drink milk. The type you need to get from your grocery store is the Karo Light which is in a clear bottle with a red label. All tubes according to maker, require you to roll the tube gently 8 times for complete mixing and uniformity. A Black and Decker converter plugs into the cord of the centrifuge and you will spin at 3000 rpm (standard high on most centrifuges) for 5 minutes.
Some labs only test hormones 2 times a week, so if they run on Tuesday and Thursday, but blood arrives on Friday, it will not be run until next Tuesday. We know the maximum normal Insulin in horses when they eat a large grain meal or given Karo Syrup and if it is under that number, the horse is not confirmed Equine Insulin Resistant and it if is over that number it is a confirmed case. If they have other problems that jack up Glucose, such as Cushings, fever, infections or high stress, which pile onto the Insulin Resistance problem, this is when you see Glucose numbers over 200. The lungs work to provide oxygen to blood, the liver works to remove toxic materials from the blood, the kidneys filter blood to remove toxins in the blood, and the organs of the digestive system work to provide nutrients to the blood. Catechins (tea polyphenols) act as antioxidants by scavenging reactive oxygen species (ROS) in the blood. Lipid peroxidation occurs when oxidation in the blood steals away electrons from the lipids in red blood cell membranes, weakening them. Antioxidants in green tea may reduce free radical damage to blood vessels and help maintain the normal function of blood vessels. The small intestine breaks down carbohydrates and the digested food-supplied glucose is absorbed through the cells of the intestine and into your bloodstream. If your body doesn’t make or use insulin properly, your cells lose their glucose-based energy, even though the glucose is in your bloodstream. When you eat, the level of glucose in your blood will rise and the pancreas will normally release more insulin into your bloodstream, lowering the glucose levels of the blood and helping glucose to enter your cells. However, if you don’t have enough insulin, or it is not sufficient to meet the needs of your body, this will lead to diabetes.
Leptin, in a Horse Glucose Challenge study, dropped by 17% on an Oral Grain Challenge but jumped up 33% in an IV Glucose Challenge. Over 30 ml., it will dribble out and make it tough to tell if the horse got what was needed. This allows the Vet to go on calls after blood drawn and not have to race back to the clinic, or have samples be unspun too long creating false low numbers. If you have the blood drawn on Monday and it is FedEx’d out that night, you should have full results by Friday of the same week. LDL particles that oxidize inside the wall of the artery can begin a cycle of cell damage and inflammation. In some diabetes types, the inability of the cells to use glucose causes the unused glucose to pass wastefully out of the body in urine. Karo Light is called this due to its light color – it has the same calories (120 calories per 2 tablespoons) as Karo Dark Syrup.
A 1000 pound horse gets only 70 cc (70 ml.) which is only 280 calories – about the same calories as in a Snickers candy bar! Below is a graph of balanced blood sugar-insulin levels throughout the day as you consume food and burn calories.
Very low Insulin numbers after a Karo Syrup Challenge (under 20 uml – Cornell) also would be suspect of the sample not being spun quickly or of a sample getting heated up in transit to the lab (not in a cooler as required). You get to see your horse’s status prior to the grass coming in and it avoids the July-November ACTH surge.
By blocking lipid peroxidation, the catechins in green tea can prevent red blood cell membranes from being damaged by oxidation and keep red blood cells healthy and strong.
Studies have shown that antioxidants in green tea can bind with the oxygenated molecules in blood, which prevents them from reacting with the LDL.
This gives you peace of mind knowing your horse is safe to start to graze, run around the field, and be a horse. This prevents the oxidation of LDL, thereby reducing the possibility of damage to blood vessels.



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