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The prostate gland enlarges with age and if the process happens in an anomalous fashion, it leads to prostate cancer (size increases upto 40 cubic centimeters and weighs around 30-45 grams).
Anomalous changes that together contribute to the disease process accumulate over years until it is at an advanced stage and symptoms are more promiscuous. Prostate cancer symptoms are usually delayed and mostly observed when the disease has metastasized to secondary organs. Metastatic disease is an advanced stage where the tumor in the prostate gland moves to secondary organs through the blood or lymphatic system. Age is considered to be the single most profound risk factor as 70% of the diagnosed patients are over the age of 65.
Read more about the causes of prostate cancer and what are some of the risk factors that make one more vulnerable to this type of cancer. The current screening parameters for early detection are ordained by the National Cancer Institute's Early Detection Research Network (EDRN). Additionally, you may be asked to complete a form to evaluate the severity of symptoms and their impact on everyday life.

An enlarged prostate means the gland has grown bigger and happens to almost all men as they age. It is believed that factors linked to aging and the testicles themselves may play a role in the growth of the gland. Similarly, if the testicles are removed after a man develops BPH, the prostate begins to shrink in size.
A small degree of prostate enlargement is present in many men over age 40 and over 90% of men older than 80 years. Classically, this is identified by the interrupted urine stream and a significantly decreased angle of the stream. Prostate cancer normally spreads through the lymphatic system and swollen lymph glands and body ache are outcomes of the process. Digital rectal exam (DRE) is a non-invasive, per-rectal examination conducted by the urologist where the overall goal is to feel by touch for tumorous outgrowths in the prostate gland. Even though both ways suffer from false detection when used individually, the sensitivity significantly improves when used together and in a and in prostatitis or benign prostatic hyperplasia (BPH).

The score of this assessment can be compared to past records to determine if the condition is worsening. The men who had their testicles removed at an early age (for example, as a result of testicular cancer) do not develop benign prostatic hypertrophy or hyperplasia (BPH). The second strategy involves a blood test for a protein made by the prostate gland, prostate specific antigen (PSA). So any positive test during screening has to be confirmed by surgical biopsies of the prostate tissue and subsequent histopathologic analyses. Specialized Program of Research Excellence (SPORE), another brain child of the National Cancer Institute, is aggressively pursuing research to define other biomarkers and symptoms that can lead to an early detection of prostate cancer.

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