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14.11.2015
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Australian cancer researchers have developed a highly promising nanomedicine that could improve treatment for pancreatic cancer – the most deadly cancer in Australia. Australian cancer researchers have developed a highly promising technology to deliver gene-silencing drugs to treat pancreatic cancer – the most chemo-resistant and deadly cancer in Australia.
When tested in mice, the new nanomedicine resulted in a 50 per cent reduction in the growth of tumours and reduced the spread of pancreatic cancer.
The UNSW-led research, published in the Biomacromolecules journal, provides new hope for pancreatic cancer patients, most of whom succumb to the disease within three to six months of diagnosis. Lead researcher Dr Phoebe Phillips, from UNSW’s Lowy Cancer Research Centre, said it was devastating for her clinical colleagues when they had to tell pancreatic cancer patients that the best chemotherapy drug available could prolong life by only 16 weeks.
The problem with therapeutically targeting this gene is that it is difficult to deliver drugs to it.
The researchers have shown that their novel nanoparticle can deliver therapeutic doses of small RNAs to pancreatic tumours in mice, despite the presence of scar tissue, and successfully inhibit ?III-tubulin. The research is a result of a collaboration with two of Australia’s leading chemists, UNSW Associate Professor Cyrille Boyer and Professor Tom Davis from Monash University.


This research was supported by the National Health and Medical Research Council and the Cancer Council NSW. For example, African-American man have a much higher risk of developing prostate cancer and having the more aggressive disease. Diets that are high in fat and processed foods, and sometimes meat and dairy, may lead to increase risk of prostate cancer. Inhibition of this gene resulted in a 50 per cent reduction in tumour growth and reduced the spread of the cancer in mice,” Dr Phillips said.
To overcome this problem, the researchers have developed a nanomedicine which consists of a state-of-the-art nanoparticle that can package small RNA molecules (DNA photocopies of cells) and greatly inhibit ?III-tubulin.
UNSW Professor Maria Kavallaris and Dr Joshua McCarroll from the Children’s Cancer Institute are also key partners in the research team.
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