Hypertrophic osteoarthropathy prostate cancer foundation,treatment of bph in dogs pc,non invasive treatments for enlarged prostate 5lx,chronic prostatitis pain treatment guidelines - 2016 Feature

19.08.2014
Diffuse metastasis, which is not infrequent in prostate cancer, can also be suspected on the basis of a 'super scan'.
However, this phenomenon in nuclear medicine has several other causes that need to be considered.Case presentationA patient with a history of prostate cancer presented with pleural fluid, peripheral edema and bone pain. A super scan of the bone was found which suggested diffuse skeletal metastasis of the prostate cancer but the patient also had a prostate specific antigen level which was not compatible with this diagnosis.
Further investigations revealed the paraneoplastic phenomenon of hypertrophic osteoarthropathy, related to an incurable carcinoma of the lung, to be the cause of the super scan.ConclusionA super scan is characterized by a high bone to soft tissue ratio on skeletal scintigraphy, with a uniform symmetrical increase in bone uptake and diminished to absent renal visualization ('absent kidney sign').
It can be seen in a variety of diseases in which there is a diffusely increased bone turnover. Diffuse skeletal metastasis of a well-differentiated prostate carcinoma is unlikely to be the cause of a super scan when the prostate specific antigen level is not elevated.
In fact, many cases of this cancer are diagnosed because of the detection of bone metastasis from a primary tumor of unknown origin at the time of presentation.
The majority of patients with metastatic prostate cancer will have multiple skeletal lesions. The differential diagnosis is wider as is described in this case report.Case presentationA 81-year-old man with an adenocarcinoma of the prostate diagnosed one year earlier presented with a five month history of gradually progressive complaints of dyspnea. At the time of diagnosis of the prostate cancer, there had been no signs of metastases and since it was an asymptomatic grade 2 prostate cancer in a man of advanced age, a watchful waiting policy was followed. The medical history revealed hypertension and a transurethral resection of the prostate six years before presentation. The patient complained of dyspnea, progressive peripheral edema, orthopnea, and painful knees and thighs which made walking extremely difficult. There had been weight loss of ten kilograms over six months, with associated loss of appetite.
Percussion and auscultation of the left lower lung revealed dullness with diminished breath sounds. There was pitting edema especially at the lower extremities, but also of both hands, which were also noted to be remarkably large.
Blood gas analysis showed a chronic compensated respiratory acidosis with an oxygen saturation of 80%.Electrocardiography showed atrial fibrillation with a left bundle branch block, similar to earlier ECGs. Chest X-ray revealed a large amount of pleural fluid on the left side and an enlarged heart without signs of vascular redistribution.
There were no signs of tumor or pulmonary metastasis on chest X-ray.Analysis of the pleural fluid was performed.
Cytological and biochemical analysis showed only lymphocytosis with no signs of malignancy or bacterial infection.


Ultrasound investigation of the abdomen showed a dilated inferior caval vein without other abnormalities. The entire presentation was compatible with right-sided heart failure in a patient with probable pulmonary hypertension. On Computed Tomography Angiography (CTA) there were no pulmonary embolisms visible but a large amount of pleural fluid was seen in the left pleural cavity.Because of the elevated alkaline phosphatase, the bone pains and the previously diagnosed prostate cancer, skeletal scintigraphy was performed.
Repeat of the earlier performed CTA indeed now showed a fluid-containing cavity in the lower left lobe surrounded by a large amount of pleural fluid at that side suggestive of a lung cancer. The left main bronchus was stenotic with tumor totally occluding the left lower lobe and almost occluding the left upper lobe.
Histological examination was not possible due to technical difficulties during the procedure. The diagnosis of incurable bronchial carcinoma with hypertrophic osteoarthropathy was made with the prostate cancer as an "innocent" bystander. There was a large undifferentiated non-small cell lung carcinoma with a diameter of 10 cm and extension in the adventitia of the esophagus and lymphatic metastasis in the hili and mediastinum. Three liters of tumor-positive pleural fluid and extensive hypertrophic osteoarthropathy was seen without distant metastasis.Figure 2A. It can be seen in a variety of diseases in which there is diffusely increased bone turn over. Diffuse skeletal metastasis, as can be observed from primary tumors of the breast, lung, prostate, bladder and lymph nodes, is the most frequent cause.
Other causes are secondary hyperparathyroidism, Paget disease, myelofibrosis and metabolic bone disease.Technetium-99m-labeled methylene diphosphonate (99mTc-MPD) bone scintigraphy performed in patients presenting with prostate cancer shows metastases in 10a€“50%.
When caused by prostate cancer, super scans are found exclusively in histologically high-grade forms.Hypertrophic Osteoarthropathy (HOA), also known as the classical Pierre Marie-Bamberger syndrome, is a systemic disorder of the bones, joints and soft tissues that develops in association with other disease processes. HOA is also frequently seen in severe cystic fibrosis, bronchiectasis, chronic empyema and lung abscess and occasionally in certain liver disorders' [4].
In some instances it may present without any underlying illness when it is called primary, idiopathic or the hereditary form of HOA in which bone and joint pain tends to be less, and the furrowing of the face and scalp tends to be more severe. Diagnosis must be based on global assessment of the clinical, laboratory and radiographic findings rather than the presence of one abnormality, since there are well-documented cases that lacked radiographically detectable periostitis [5]. The incidence of clinically apparent HOA in patients diagnosed with lung cancer is approximately 4a€“5% [7]. Several pathogenetic theories have focused on the vascular changes and proliferation that might be caused by circulating growth factors that normally are inactivated in the lungs. Pulmonary shunting caused by the several disease processes that are associated with HOA causes a faulty pulmonary clearance of macrothrombocytes, which release growth factors in the systemic circulation.


Elevated levels of platelet-derived growth factor (PDGF), endothelin-1 (ET-1), I?-thromboglobulin (I?-TG) and vascular endothelial growth factor (VEGF) [8] have all been shown to be elevated in patients with HOA.HOA has no prognostic significance and early detection may lead to detection of potentially resectable lung carcinoma. Subclinical cases can be diagnosed by radiographs or, with more sensitivity, by skeletal scintigraphy with an incidence in bronchogenic carcinoma of up to 20% [6]. Usually scintigraphic abnormalities are found in the peripheral skeleton and are not easily mistaken for diffuse skeletal metastasis. Its appearance can range from increased 'bracelet-like' appearance to more diffusely increased uptake at the distal ends of the long bones.
Although usually located in the peripheral skeleton, it can also affect the skull, claviculae, ribs and scapulae [9, 10]. Sometimes along the cortical margins, a 'parallel track sign' due to the periosteal bone formation can be seen. To the best of our knowledge this is the first report of a super scan as the presenting feature of HOA.This case report clearly illustrates the pitfalls of diagnostic tests.
Although the clinical presentation almost entirely fitted the suggested diagnosis of diffusely metastasized prostate carcinoma as an explanation for the symptoms, signs and bone scintigraphy, it was the normal PSA, which indicated that an alternative diagnosis should be sought.
In patients with poorly differentiated (grade 3) or clinically advanced (stages T3a€“4) tumors it has a negative predictive value of only 70 and 50%, respectively [10, 11]. And although advanced technologies are at our disposal, in almost 4.5 liters of pleural fluid no malignant cells were found.
Imaging technologies are so refined that peripheral embolism on a CTA can be detected, but gross abnormalities like pleural fluid and atelectasis can cover up a malignant tumor of 10 cm in diameter.ConclusionThis case illustrates that a super scan of the bone is a distinct entity in nuclear medicine that can point towards several different bone disorders. Malignancy is a frequent cause, but the most obvious cause in that setting, namely diffuse skeletal metastasis, is not the only one that should be considered. In prostate carcinoma, especially when well-differentiated with a low PSA level, skeletal metastasis is unlikely.
As in this case, non-metastatic paraneoplastic, or even benign diagnoses should be considered. Usually scintigraphic abnormalities are confined to the peripheral skeleton.In modern day medical practice, a clinician is often confronted with the results of several diagnostic modalities.
It remains the task of the clinician to be critical and to interpret the different aspects and findings in relation to each other.ConsentInformed and verbal consent was obtained from the patient for both publication and use of the clinical photographs.



Prostate removal symptoms 8 dpo
Bph allergy medications 2014


Comments to “Hypertrophic osteoarthropathy prostate cancer foundation”

  1. WARLOCK_MAN:
    Prostate goes through two main spreading, cancer cells may attach to other prostatitis.
  2. PRESIDENT:
    Activity the following day, although heavy lifting.