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AntidepressantsAn unfortunate side effect from some antidepressants is weight gain, which may occur in up to 25% of people taking them long-term. Talk to your GP about changing to another drug if you think your antidepressant is causing weight gain. But remember that some people experience weight gain after beginning drug treatment simply because they're feeling better, which leads to improved appetite. CorticosteroidsAnti-inflammatory steroid medications are notorious for causing weight gain. Although weight gain is common, the severity of this side effect depends on the strength of the dose and length of time taking the drug.

Other drugs that may cause weight gainSeveral other prescription drugs have been associated with weight gain. It is thought that some women taking the combination pill may experience some weight gain related to fluid retention, but this is usually short-term.
HypothyroidismIf your thyroid (the butterfly-shaped gland in the front of your neck) is not making enough thyroid hormone, you're probably feeling tired, weak, cold and gaining weight. But where you gain weight may be related to menopause, with fat accumulating around your waist, not around your hips and thighs.
Cushing's syndromeWeight gain is a common symptom of Cushing syndrome, a condition in which you are exposed to too much of the hormone cortisol, which in turn causes weight gain and other abnormalities. The weight tends to gravitate to the abdomen, putting women at greater risk of heart disease.

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