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Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Clipping is a handy way to collect and organize the most important slides from a presentation. Indications for collagen injection are acne scars, traumatic scars, photoaging, wrinkles, and gravitational rhytides. Adequate methods for hair removal have long been in demand; long-term hair removal with minimal adverse effects is the ultimate goal. For news, CME, and expert viewpoints on aesthetic procedures, visit Medscape’s Aesthetic Medicine Resource Center. This method is an easy and practical way to remove single hairs and can be utilized by most individuals for clearing small numbers of unwanted hairs. Plucking often induces a hair follicle into its active growth phase, or anagen, thus stimulating new hair growth.
Although fast and effective for clearing a large surface area of hair, shaving is the most temporary method of hair removal, as it only cuts the hair at the skin surface.
Disadvantages include skin lacerations, potential pyoderma, folliculitis, ingrown hairs, and postinflammatory hyperpigmentation.
Application of a warmed wax or a sugary paste to areas of hair-bearing skin and then removing it, along with the unwanted hair, is a popular method of hair removal and is commonly performed at salons and spas. Stripping of the wax or sugar paste from the skin is often unpleasant or painful and may cause adverse effects such as irritant dermatitis, true or pseudofolliculitis, hyperpigmentation, scarring, and thermal burns from hot wax or poor technique. Preparations containing thioglycolates or strontium sulfide are the most widely used chemical depilatories. The major adverse effect is the potential for irritant or allergic contact dermatitis, which may cause significant itching or rash. Bleaching with hydrogen peroxide is an effective method of disguising the presence of hair but does not actually remove hair. This is particularly effective for individuals with fine but dark and, therefore, noticeable hair on the arms, face, or neck. Successful electrolysis can achieve permanent hair follicle destruction to some degree in 15-80% of patients. Available by prescription only, eflornithine 13.9% cream was approved for topical use by the Food and Drug Administration (FDA) on July 31, 2000.
The most common adverse effects of topical eflornithine cream include, but are not limited to, acne, pseudofolliculitis barbae, skin irritation, and rash.
Since 1996, when photoepilation-using laser technology first became available for use, numerous advances have occurred in laser hair removal, resulting in different types of lasers now available for treatment of excessive hair.
Adverse effects are primarily related to epidermal damage by partial absorption of laser energy by the surrounding skin. Excessive hair growth in men or women may be classified into either hirsutism or hypertrichosis, depending upon the distribution on the body.
Hirsutism is defined as an excess of thicker darker hairs in a male pattern of distribution where they are normally thin or absent in the female. Treatment for excessive hair in hirsutism is not generally required if no clear etiology of the disorder exists and the patient does not find the excessive hair growth objectionable. A hair growth pattern in a nonandrogen-dependent pattern is termed hypertrichosis and may involve vellus, terminal, or lanugo type hair. When hair grows in a curly and tightly coiled pattern, patients may be afflicted with numerous ingrown hairs that may cause skin irritation, papules, and pustules. Acne keloidalis nuchae is most commonly seen in African Americans and is characterized by follicular papules and chronic plaques on the occipital area of the scalp.
In order to gain a more comprehensive understanding of how laser hair removal procedures work, one must have knowledge of relevant hair microanatomy, physiology, and growth cycles associated with growth of hair on the body. Hair follicles are found over almost the entire body surface, with the exceptions of the palms of the hands and soles of the feet. Each hair follicle may be divided into 4 histologic divisions, which are (from superficial to deep) the infundibulum, isthmus, stem, and bulb.
The infundibulum is the most distal portion of the hair in the follicle, extending from the surface of the skin down to the entrance of the apocrine gland into the follicle. The isthmus of the hair then extends from the apocrine gland entrance to the connection to the sebaceous gland. Still deeper, the stem extends from the sebaceous gland opening to the erector pili muscle attachment. The bulb of the hair follicle is deep to the attachment of the erector pili muscle and is the site of the follicular matrix.

In catagen (the regression phase), matrix cells degenerate and the bulb begins to atrophy, causing the hair follicle to shrink. Melanin is a biologic pigment that is found in many cells in the body and is primarily responsible for the color of the skin and hair.
Melanin is the target chromophore, or light-absorbing molecule, for laser treatment and has an absorption spectrum of 250–1200 nm, which spans the entire ultraviolet, visible, and infrared light ranges. For patients with chronic or active herpes simplex virus infections, pretreatment with antiviral medications can be initiated, especially when lesions appear in the body area to be treated. Patients with a history of hypertrophic scarring or keloid formation should be treated judiciously because of possible problems in healing if skin damage is sustained. Patients taking isotretinoin (Accutane) should stop the medication for 6 months prior to laser hair removal treatment because of skin sensitivity. Laser hair removal may be contraindicated in patients taking photosensitizing drugs activated by ultraviolet A wavelengths. Patients with tattoos on the body surface areas selected for laser hair removal should be instructed that the appearance of the tattoo might be affected by the use of laser devices. Effective hair removal with laser-assisted devices requires the presence of a hair follicle for photothermolysis to commence. Up to 22% of women in North America have excessive or unwanted facial hair, which negatively affects the quality of life for many individuals.1 Men also feel compelled to rid themselves of unwanted body hair, as dictated by popular culture and appearance anxieties.
Laser hair removal has become well established as an effective form of treatment for unwanted body hair.
This goal will likely be reached with a more complete understanding of anatomy, physiology, hair growth cycles, and laser-tissue interactions, and as more sophisticated technologies emerge.
Additionally, it can create postinflammatory hyperpigmentation, true or pseudofolliculitis, and, very rarely, scarring.
As the hair continues to grow, the blunt end of the cut hair is more noticeable because it is thicker than a normal tapered end. Many women may not use this method on certain areas of the body because of masculine connotations of shaving the face and neck.
This method may be used over large skin surface areas (eg, legs, arms, back) or small controlled areas (eg, face, eyebrow, bikini area). These agents disrupt the disulfide bonds (especially cysteine) that hold hair cells together, thus dissolving the hair. It employs a weak direct current that passes through a negative electrode (anode) inserted in the hair follicle and a positive electrode (cathode) in the form of a wet pad in the patient’s hand.
Topical eflornithine may irreversibly inhibit skin ornithine decarboxylase activity, resulting in a reduction in the rate of hair growth.1 The onset of action may take 4-8 weeks of using the topical cream for unwanted facial hair on the mustache and chin area. Laser hair removal is based on the theory of selective photothermolysis, or selective destruction of the follicular unit, resulting in significant hair reduction in treated areas. This effect has been more pronounced in darker-skinned individuals whose increased skin melanin concentration places them at a higher risk of adverse effects. Affected areas are those that are stimulated by circulating androgens and include the face, chest, arms, and areolae. However, treatment generally relies upon antiandrogen to inhibit the effects of androgens on the skin, such as 5-alpha-reductase inhibitors, spironolactone, or flutamide. This may be associated with a number of congenital syndromes or occur as an isolated finding.
Vellus hair can be found over the entire body and appears as soft, fine, short hairs that are nonpigmented or very lightly pigmented and can be all but invisible. As the hair follicles develop, they become associated with developing sebaceous glands, apocrine glands, and erector pili muscles. As hairs progress through these phases, they are affected differently by treatment with laser-assisted hair removal.
On the scalp, hair follicles spend up to 10 years in anagen, but on the trunk, brow, and limbs, anagen lasts no longer than 6 months.
This fact becomes important because only hairs in the anagen phase of development are susceptible to injury during a session of laser-assisted hair removal. The primary function of melanin in the skin is to protect it from the harmful effects of sunlight.
Antiviral treatment typically begins 1 day prior to laser treatment and continues for a total of 5-7 days. Lasers operating in the visible to infrared spectrum are generally thought to be safe for use with patients taking these medications. Prior history of recent waxing, plucking, sugaring, electrolysis, or other methods of complete hair removal should be ascertained.

New hair growth appears more slowly than with shaving, as the hair must grow to the level of the skin surface before it appears. Like shaving, this method offers only a brief hair-free period, as hair continues to grow from the level of the skin surface. Follicular destruction is achieved via the formation of toxic sodium hydroxide (a free radical).
These adverse effects include blistering, hypo- or hyperpigmentation, scabbing, or, very rarely, permanent scarring. This disorder may be caused by several types of endocrine disorders that lead to excessively high androgen levels or by hair follicles that are particularly sensitive to normal levels of androgens. Whether choosing to treat medically or with any of the aforementioned methods of hair removal, patients must understand that treatment is long-term and must be continued to maintain low levels of visible hair. What is considered a normal amount and appearance of body hair can vary widely among different ethnic groups, and treatment should be tailored to the needs or desires of the individual patient. Pseudofolliculitis barbae occurs most commonly in the underarm or bikini area with shaving, or, in men, at the lower neck, where coarse facial hair grows. In early lesions, an entrapped hair is usually in evidence, and early treatment with laser hair removal is most effective at this stage. Hair follicles may be straight, wavy, helical, or spiral, and the morphologic features of follicles vary among different anatomic locations and racial backgrounds. Terminal hair is the longer, coarser, and more darkly pigmented hair found on the scalp, underarm area, and groin.
Now the follicle contains only the superficial components, the infundibulum and the isthmus.
Thus, multiple treatments are necessary to treat all hair follicles on a given body surface area.
The amount of melanin in hair and skin varies widely between individuals and races and is determined by the concentration of melanin within the skin.
This level of impairment is comparable to that experienced by patients with psoriasis and eczema and eclipses that experienced by patients with acne. Electrothermolysis uses an alternating current that causes direct thermal destruction of the hair follicle. Hypertrichosis may be an unwanted adverse effect of medications such as cyclosporine, minoxidil, and oral and topical corticosteroids that are used to treat other disorders.
Laser hair removal is effective in treating this disorder by temporarily or permanently removing the hair from the chronically inflamed lesion. The entrapped hair acts as a foreign body in the skin and, when chronic, can cause skin changes, decreased hair growth, and scarring of the affected area.
White persons typically have thinner hair shafts than persons of Asian or African American backgrounds.
Ideally, the laser energy is absorbed selectively by the melanocytic hair bulb and matrix, thus destroying the hair follicle and its capacity to regrow, while protecting the surrounding tissue where the melanin concentration is minimal. Laser treatment leads to resolution and healing of the papular and pustular lesions, dramatically improving skin texture and the associated postinflammatory hyperpigmentation. The treatment goals with laser hair removal for this disorder are to destroy the impacted hair and cause a delay in new hair growth, thus decreasing further scarring. The density of hair follicles in a given skin surface area also varies widely among individuals. Terminal hair is also found on the androgen-sensitive areas of the body, such as the beard and chest area in males. In persons with darker skin, however, the higher levels of melanin in heavily pigmented skin compete as a chromophore for the laser light. Hair shape is also highly variable; on cross-section, straight hair tends to be round and wavy or spiral hair is oval. Although greatly outnumbered by vellus hairs, terminal hairs are more important, as they are responsible for the appearance of hair on the body. This light is converted to heat and can cause skin blistering or changes in skin pigmentation. Keep in mind the variations in color, texture, and amount of hair on a given body surface area when deciding upon the need for hair removal procedures. They may aid in enhancing a person’s image, or they can cause great anguish and distress due to their distribution, length, or texture.

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