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Diabetes insipidus is a condition in which your ability to control the balance of water within your body is not working properly. Your kidneys are not able to retain water and this causes you to pass large amounts of urine. Also, water levels in your body help to control the levels of some important salts, particularly sodium and potassium. It is then transported to another part of your brain, the pituitary gland, from where it is released into your bloodstream. It causes your kidneys to pass out less water in your urine (your urine becomes more concentrated). However, sometimes it can occur with other problems because the production of other hormones that are released by the pituitary gland is also affected. Cranial diabetes insipidus is sometimes called central diabetes insipidus or neurogenic diabetes insipidus. In nephrogenic diabetes insipidus, ADH is still being released by your brain but your kidneys become resistent to the effects of ADH.

This means that ADH is not able to work properly to allow your kidneys to concentrate your urine.
Again, this means that you will develop polyuria (where you pass large amounts of diluted urine) and polydipsia (where you are excessively thirsty and so drink more). Older children may have problems with bedwetting at night-time and also incontinence of urine during the daytime. The volume of urine that you produce will be measured to see if there is any change in the amount.
If your body is working normally, the amount of urine that you produce should reduce if you have not drunk anything for a long time.
However, if you have diabetes insipidus, there will be little change in your urine production. For example, if you are found to have a tumour affecting your hypothalamus or pituitary gland.
The aim is that the medicine should replace the ADH that your body is lacking and so will help to control the amount of urine that you pass.

If you have mild nephrogenic diabetes insipidus, your doctor may suggest that you drink plenty of fluids to avoid dehydration. They may also suggest some changes to your diet to help reduce the amount of urine that you produce. For example, eating fewer salty and processed foods and fewer foods that contain protein (such as meat, fish and eggs).
You also need to take care in hot weather because you will sweat more and so may become dehydrated more easily. This is so that healthcare professionals know about your condition, even if you have an accident or are unwell and become unconscious and so are not able to tell them yourself.

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