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07.02.2016, admin  
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Myofibrils contain actin and myosin myofilaments arranged in sarcomeres (sarcomeres can be said to be the contractile elements of the myofibrils). Myosin filaments are thick, consist of two molecules with entertwined tails and two heads that bind to actin. Actin filaments consist of two entertwined chains of actin monomers with myosin head binding sites. The sarcolemma (plasma membrane) forms tubes that dip into cell –T-tubules (transverse) - over each z-disc. A nerve impulse travels from neuromuscular junction, along sarcolemma, down T-tubules, stimulates calcium release from sarcoplasmic reticulum, which allows the thin filaments to slide to the center of the sarcomere, causing it to shorten and the muscle to contract. The interaction between myosin and actin pulls the actin filaments toward the center of the sarcomere.


If calcium is present and the myosin head binding sites are unblocked the myosin heads form crossbridges with the actin filaments. The myosin heads relax into their low energy conformation, pulling the actin filaments toward the center of the sarcomere (causing all the sarcomeres along the myofibril to shorten, causing the myofibril to shorten, causing the muscle to shorten - or contract). Anaerobic production of ATP by glycolysis occurs during strenuous exercise after CP stores are exhausted. Slow-twitch muscle-fibers on the other hand, contract slowly and support smoother, lower intensity repetitive contractions, related to endurance-type activities.
In closingWhile not wanting to refute any of the advice given on this page, I would suggest that you also consult the page on Somatotypes, as it discusses important aspects which are linked to muscle structure and fiber properties.
The myosin binding sites are blocked by a linear molecule of tropomyosin, which runs the length of the thin filament in the groove between the two chains.


ATP binding causes the myosin head to relase from the actin filament and the cycle starts all over.
However, they are  totally burned-out by the time they cross the finish-line a mere 100 meters later. I find that focusing on the medium rep-range and occasionally doing some lower and higher-rep work, keeps me in my desired optimal shape.



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