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05.02.2015, admin  
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Serum testosterone undergoes a natural daily variation in levels as shown by the chart below. A detailed physical examination and biochemical investigation is mandatory in a person suspected of LOH.
Free testosterone is calculated from measured total testosterone and SHBG or measured by a reliable free testosterone laboratory.
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Main Outcome Measures: Variability of serum T 2 hours after the gel application on two outpatient visits and at multiple time points over 24 hours during the inpatient day was measured. Results: On-treatment T levels varied substantially on the 2 ambulatory days and over 24 hours during the inpatient day. Conclusion: Large within-individual variations in serum T after T gel application render ambulatory 2-hour postapplication T level a poor indicator of average serum T on another day. Testosterone replacement therapy improves the health-related quality of life of men diagnosed with late-onset hypogonadism.
Age, Body Mass Index, and Frequency of Sexual Activity are Independent Predictors of Testosterone Deficiency in Men With Erectile Dysfunction. Ambulatory 2-hour postapplication T levels did not correlate significantly with either 2-hour postapplication serum T or Cavg0–24 measured during the inpatient day. Our data point out the limitations of dose adjustments based on a single postapplication serum T measurement. Swerdloff, MD, Division of Endocrinology, Department of Medicine, Walter Martin Research Building, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Building, 1000 Carson Street, Torrance, CA 90509. Any medical or health advice provided and hosted on this site will only be given by medically trained and qualified professionals unless a clear statement is made that the advice offered is from a non-medically qualified individual or organisation. Where appropriate, information contained on this site will be supported by clear references to source data and, where possible, have specific HTML links to that data.



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