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21.04.2014, admin  
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Ball-and-stick model of the testosterone molecule, C19H28O2, as found in the crystal structure of testosterone monohydrate. Because some males have attempted to compete as female athletes over the years, major sporting promoters began testing those who entered competitions, first via visual inspection of genitals, than later, by taking blood tests and checking for X and Y chromosomes. As Karkazis and Jordan-Young note, the two studies that have been done that underlie decision making by such organizations as the IAAF and IOC, include one called the GH-2000 where 234 female athletes (and 446 males) competing in Olympic events were tested for growth hormones and also their testosterone levels. The other study was conducted during the 2011 World Championships leading up to the Olympics, where 849 female athletes had their testosterone levels checkeda€”they found that just 1.5 percent of those tested had levels that were considered to be higher than the normal range for women.
Karkazis and Jordan-Young suggest these discrepancies, plus other problems with the studies themselves (such as the fact that one study included only women and focused only on women in track and field and the other study relied on samples that were taken from athletes shortly after they had competed when their testosterone levels were are their highest) make testing in this way "grossly unfair" and should be halted and that a new method of testing be found which includes focusing on which gender individuals identify themselves as. Abstract Sexual dimorphism of testosterone (T) in elite athletes was at the center of a recent case at the "Supreme Court of Sport," the Court of Arbitration for Sport in Switzerland, after teenage Indian sprinter Dutee Chand challenged a sports policy regulating competition eligibility of women with naturally high T.
Previous cancer research has revealed that women are less likely than men to suffer from non-sex specific cancers such as cancer of the colon, pancreas and stomach. While testosterone replacement therapies may be controversial in males, new research in The FASEB Journal may extend this controversy to females too. Obesity is linked to changes in our gut microbesa€”the trillions of tiny organisms that inhabit our intestines. Duke researchers have developed a system that allows real-time optical and electrical observations of the gut's nervous system in a live animal.
A new vaccine allows pneumonia-causing bacteria to colonize inside the body, springing into action only if the bacteria pose a threat. Scientists at USC have developed a new tool to modify brain activity and memory in targeted ways, without the help of any drugs or chemicals. Dandona and his co-authors have been reporting on the relationship between insulin sensitivity and testosterone in Type 2 diabetic males since the publication of their seminal paper in 2004, demonstrating the association between low testosterone levels and Type 2 diabetes. Men with Type 2 diabetes who have low testosterone levels can benefit significantly from testosterone treatment. That is the conclusion of University at Buffalo researchers who conducted the first randomized, double-blind, placebo-controlled study of testosterone treatment in Type 2 diabetic men that comprehensively investigated the role of insulin resistance and inflammation, before and after treatment with testosterone.
The study, funded by the National Institutes of Health, was published online before print in Diabetes Care in November.


The UB researchers found that low testosterone levels were associated with significantly decreased insulin sensitivity; this was demonstrated by a 36 percent decrease in the rate at which glucose is taken up by tissues when patients with low testosterone were administered a set concentration of insulin.
Dandona and his co-authors have been reporting on the relationship between insulin sensitivity and testosterone in Type 2 diabetic males since the publication of their seminal paper in 2004 when they demonstrated the association between low testosterone levels and Type 2 diabetes. The study found that while there was no change in body weight, testosterone treatment produced a reduction in total body fat of 3 kilograms (more than six pounds) while increasing muscle mass by the same amount. While patients' hemoglobin A1C (HbA1c) levels did not go down, a necessary indicator that testosterone can help control diabetes, Dandona noted that fasting glucose levels had diminished significantly, by 12 milligrams per deciliter. The UB researchers are also interested in how testosterone treatment may impact insulin resistance and inflammation in specific patient populations, such as those with chronic renal failure and hypogonadism, which they reported on in a paper published online in June in the European Journal of Endocrinology.
Dandona and his colleagues also are interested in how obesity in young men affects testosterone levels, a topic they published on in 2012, when they found that obese teen boys have 50 percent less testosterone than their lean peers. It's not estrogen produced by body fat that causes low levels of testosterone in type 2 diabetic men, according to a University at Buffalo study published last month in Diabetes Care.
Restoring testosterone production in men may be as effective as replacing it, without compromising their fertility. Obesity is a risk factor for developing type 2 diabetes, yet not all obese humans develop the disease.
Germs could play a role in the development of type 1 diabetes by triggering the body's immune system to destroy the cells that produce insulin, new research suggests. A Mayo Clinic study suggests laboratory findings do not tell the whole story of how the diabetes drug metformin works to limit the level of glucose in the blood. A sleeping pancreas releases less insulin, but how much insulin drops each night may differ from person to person, suggests a study published May 12, 2016 in Cell Metabolism. New research from Denmark reveals the gene that explains one quarter of all familial hypercholesterolemia with very high blood cholesterol. Katrina Karkazis and Rebecca Jordan-Young note that thus far there have only been two serious studies done on the topic and they came back with conflicting results, which suggests that sports organizations that use testosterone levels to exclude women from competing with other women are unfair. This association was extended to obesity in 2010 in a study of more than 2,000 obese men: They found that 33 percent of Type 2 diabetics - whether or not they were obesea€”and 25 percent of non-diabetic, obese males have low testosterone concentrations. Prior to being treated, the 44 men in the study with low testosterone levels expressed significantly lower levels of insulin signaling genes and, thus, diminished insulin sensitivity.


At the same time, there was a similar increase in the expression of the major genes that mediate insulin signaling. He said that a significant improvement in HbA1c may eventually be seen when longer term studies are carried out.
That paper reported that two-thirds of Type 2 diabetic men with chronic kidney disease have low testosterone levels and that among patients on dialysis, a remarkable 90 percent have low testosterone.
I followed the ADA diet 100% for a few weeks but it was ineffective at getting my blood sugar below 140. In 2011, the IAAF set a limit on testosterone levels as the sole means of qualification of competing as female and that policy has generated some heat from some quarters as some athletes have been banned from competing and others have undergone surgical procedures to correct the problem. Policymakers infer that men's higher T is the "one factor [that] makes a decisive difference" between men's and women's athletic performances (2)a€”so that women with naturally high T may unfairly enjoy a "massive androgenic advantage" over other women athletes (2). These men were randomized to receive a testosterone injection or a placebo every week for 24 weeks. Dandona was senior author on that paper with Sandeep Dhindsa, MD, previously a faculty member at the Jacobs School of Medicine and Biomedical Sciences and now at Texas Tech University Health Sciences Center.
We report on an emerging scientific debate about whether the sex gap in T applies to elite athletes.
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