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Fatty acids have to be activated prior to their entry into mitochondrial matrix where the enzymes of β-oxidation of fatty acids are located. ConceptDraw PRO provides export of vector graphic multipage documents into multiple file formats: vector graphics (SVG, EMF, EPS), bitmap graphics (PNG, JPEG, GIF, BMP, TIFF), web documents (HTML, PDF), PowerPoint presentations (PPT), Adobe Flash (SWF). Usage of them is covered by Creative Commons “Attribution Non-Commercial No Derivatives” License. Activated fatty acids are then transported from cytosol to the mitochondrial matrix with the help of carnitine transporter. Ketone bodies are synthesized in the liver but they are utilized by extra hepatic tissues as fuels. Enzymes involved in the synthesis are partly located in the endoplasmic reticulum and partly in the cytoplasm. Cycloxygenase enzyme catalyzes the reaction in which C20 fatty acid is converted to prostaglandins.
Products of lipid digestion aggregate to form mixed micelles and are absorbed into the small intestine.
Quite what the purpose of the BAD–glucokinase link might be is unclear, but these proteins are known to influence apoptosis and metabolism, respectively.


Ketone bodies are accumulated in the blood if the rate of synthesis exceeds the ability of extra hepatic tissues to utilize them. This leads to excess ketone bodies in blood, excretion of ketone bodies in urine and smell of acetone in breath. HMG CoA, mevalonate, isopentenyl pyrophosphate, squalene are some of the important intermediate compounds formed during cholesterol synthesis. Fatty acids are activated, transported across mitochondrial membrane with the help of carnitine transporter. BAX might interact with the voltage-dependent anion channel (VDAC), part of the channel that exchanges newly synthesized ATP for ADP7.
TAGs are synthesized from fatty acyl CoA and glycerol 3-phosphate or dihydroxy acetone phosphate.
Elevation of lipids in blood leads to the deposition of cholesterol on the arterial walls leading to atherosclerosis. Similarly oxidation of unsaturated and odd chain fatty acids also take place with additional reactions. This interaction might promote the release of cytochrome c from mitochondria11, resulting in the activation of caspases, which in turn dismantle the cell.


Products of lipid digestion aggregate to form mixed micelles and are absorbed into the small intestine. In uncontrolled diabetes mellitus and starvation, excessive ketone bodies are formed, leading to ketosis.
The metabolic role of glucokinase is to phosphorylate glucose to generate glucose 6-phosphate.
Acetyl Coenzyme A is the precursor of fatty acid synthesis as well as cholesterol biosynthesis. Elevation of lipids in blood leads to deposition of cholesterol plaques in the arterial walls leading to atherosclerosis. Prostaglandins and leukotrienes are synthesized from twenty carbon unsaturated fatty acids.




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