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09.09.2014, admin  
Category: Muscle Magazine

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This study was designed to assess the impact of treatment with rosiglitazone, pravastatin and rhGH alone and in combination on body composition in HALS.
60 HIV-infected men with HALS were randomized into 5 arms to receive daily therapy with: (1) pravastatin, 40mg, (2) rosiglitazone, 4 mg, or (3) pravastatin and rosiglitazone, for 48 weeks, or (4) recombinant human growth hormone (rhGH, Serostim, 2mg) or (5) rhGH and rosiglitazone for 12 weeks. Pravastatin had a non-significant effect of increasing limb fat by DEXA and rosiglitazone had a non-significant effect of decreasing limb fat by DEXA. Results: Neither pravastatin nor rosiglitazone, either alone or in combination affected measures of body composition by DEXA, CT or clinical criteria. Conclusions: Neither pravastatin nor rosiglitazone are effective therapies for body composition changes in HALS.

The presence of the acetate ester allows trinabol to display a rapid initial physiological response.
It demonstrates the difficulty in treating HALS and thus emphasises the importance of ART choice in HIV.
Beyond switching to a thymidine NRTI-sparing regimen, few interventions have shown reliable benefit.
Assessments every 12 weeks included dual energy X-ray absorptiometry (DEXA), computed tomography (CT), biochemistry and clinical anthropometrics. The other two esters, which release at slower rates, prolong the physiological response with a relatively flat absorption curve over the duation of the injection life-cycle.
Adding rosiglitazone to rhGH treatment abrogated the insulin resistance seen with rhGH alone.

Trinabol has a great effect on promoting protein synthesis, as well as creating a positive nitrogen balance. Growth hormone may have beneficial effects on body composition but exacerbates insulin resistance. In laboratory tests, it has been demonstrated that trenbolone acetate increases protein and decreases fat deposition.

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