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06.10.2014, admin  
Category: Muscle Magazine

Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF, GHRF), somatoliberin or somatocrinin, is a releasing hormone for growth hormone.
GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophyseal portal system to the anterior pituitary gland, where it stimulates growth hormone (GH) secretion by stimulating the growth hormone-releasing hormone receptor. GHRH stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary. The GHRHR is a member of the secretin family of G protein-coupled receptors, and is located on chromosome 7.
The cAMP-dependent pathway is initiated by the binding of GHRH to its receptor, causing receptor conformation that activates Gs alpha subunit of the closely associated G-Protein complex on the intracellular side. In the phospholipase C pathway, GHRH stimulates phospholipase C (PLC) through the ??-complex of heterotrimeric G-proteins.
Activation of GHRHRs by GHRH also conveys opening of Na+ channels by phosphatidylinositol 4,5-bisphosphate, causing cell depolarization. Many GHRH analogs remain primarily research chemicals, although some have specific applications.

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Central congenital hypothyroidism (CCH) may occur in isolation, or more frequently in combination with additional pituitary hormone deficits with or without associated extrapituitary abnormalities.
Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice. Xie TY1, Ngo ST1,2,3, Veldhuis JD4, Jeffery PL5, Chopin LK5, Tschop M6, Waters MJ7, Tolle V8, Epelbaum J8, Chen C1, Steyn FJ1,3.
Ghrelin, a gut hormone originating from the post-translational cleavage of preproghrelin, is the endogenous ligand of growth hormone secretagogue receptor 1a (GHS-R1a).
Information about Growth hormone-releasing hormone in the free online English dictionary and encyclopedia. It is a 44[1]-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus.

This results in stimulation of membrane-bound adenylyl cyclase and increased intracellular cyclic adenosine monophosphate (cAMP). Somatostatin is released from neurosecretory nerve terminals of periventricular somatostatin neurons, and is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary where it inhibits GH secretion. Printer Friendly Dictionary, Encyclopedia and Thesaurus - The Free Dictionary 6,718,795,192 visitors served.
Somatostatin and GHRH are secreted in alternation, giving rise to the markedly pulsatile secretion of GH.
Phosphorylated CREB, together with its coactivators, p300 and CREB-binding protein (CBP) enhances the transcription of GH by binding to CREs cAMP-response elements in the promoter region of the GH gene.

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