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Endocrine Physiology lecture 3 Dale Buchanan Hales, PhD Department of Physiology & Biophysics. Anterior pituitary Anterior pituitary: connected to the hypothalamus by hypothalmoanterior pituitary portal vessels. During fasting, GH antagonizes insulin action and helps mediate glucose sparing, ie stimulates gluconeogenesis In general, during anabolic or absorptive phase, GH facilitates insulin action, to promote growth.
Acromegaly and Gigantism Caused by eosinophilic adenomas of somatotrophs Excess GH leads to development of gigantism if hypersecretion is present during early life– a rare condition –Symmetrical enlargement of body resulting in true giant with overgrowth of long bones, connective tissue and visceral organs. ACTH is made up of 39 amino acids Regulates adrenal cortex and synthesis of adrenocorticosteroids -MSH resides in first 13 AA of ACTH -MSH stimulates melanocytes and can darken skin Overproduction of ACTH may accompany increased pigmentation due to -MSH.


Deficiency of vasopressin (ADH) in hereditary diabetes insipidus is accompanied by decreased ACTH release. Glycoprotein hormones Glycoprotein hormones contain two subunits, a common subunit and a distinct subunit: TSH, LH, FSH and hCG. The anterior pituitary produces six peptide hormones: –prolactin, growth hormone (GH), –thyroid stimulating hormone (TSH), –adrenocorticotropic hormone (ACTH), –follicle-stimulating hormone (FSH), –luteinizing hormone (LH). Other neuropeptide products include and lipotropin, -endorphin, and -melanocyte- stimulating hormone ( -MSH).
Many vasopressinergic neurons also contain CRH resulting in co-release of two peptides into portal blood.


When there is adequate glucose as during absorptive phase, and glucose uptake is required, then GH secretion is inhibited so it won't counter act insulin action.



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