Blisters are small pockets of liquid that form on the outer layer of the skin after the skin becomes damaged (usually caused by forceful rubbing or burning).
Blisters prevent the area from becoming further damaged by protecting the skin underneath and giving it adequate time to heal.
Blisters are filled with serum, which is essentially blood plasma without fibrinogens (the red blood cells and clotting agents are removed).
A blister can form on any part of the body, but the most common parts are the feet and hands.
Friction blisters are more likely to develop in skin areas with a thick horny layer held tightly to the underlying structures, such as the soles of the feet or the palms of the hands. Friction or rubbing on the skin - intense friction or rubbing on the skin can result in the formation of a blister if it continues for long enough. Exposure to chemicals - when the skin comes in contact with chemicals found in detergents and solvents blisters can develop. Wearing comfortable shoes and using socks that can manage moisture can prevent blisters from developing on the feet, particularly among those who sweat a lot - sport socks help keep the feet dry.
Using a protective layer of padding and using a friction management patch applied to shoes also help prevent blisters.
Blisters caused by sunburn can be prevented if you apply a good sunscreen, wear protective clothing (including a hat), and limit your exposure.
Antiperspirants with emollients and drying powders applied to the feet do not reduce the risk of developing friction blisters. According to the National Health Service2, UK, you should not peel off the dead skin on top of the blister if it bursts. If the top layer of dead skin has already rubbed off the burst blister, do not try and peel any of the remaining skin.

August 20, 2014 By Ashley Marcin Comments Of all the parts of the body at play during walking and jogging, the feet take the brunt of the burden. If you’ve ever worn a pair of shoes that were either non-supportive or poor fitting, you were probably inconvenienced with a blister or two. You may cover blisters on feet with a gauze bandage, plaster, moleskin or any other cover that provides protection to the area. If the blister is in an uncomfortable area, such as the bottom of your foot, use a moleskin pad that is shaped like a doughnut to protect this area. Don’t remove the flap of skin left by the open blister unless it is very dirty, torn or has pus underneath it. Keep covered with an antibiotic ointment and a bandage unless you are repeating the original exercise that caused foot blisters, in that case refer to dressing above. Draining a blister should only be necessary if they are large or painful; however, this procedure needs to be done aseptically and safely at home. Note: Do not drain a blister on your foot if you are at risk for developing infection from diseases such as diabetes, HIV, cancer or heart disease. Take an oatmeal bath or place a washcloth soaked with oatmeal over itchy blisters on feet for approximately 15 minutes. Calamine lotion, although not a home remedy, helps to dry out blisters that are itchy and draining.
These are just a few examples of remedies and treatments you can provide at home to aid in healing of your blisters on feet.
However, some blisters may be filled with blood (blood blisters) - if they become infected or inflamed they can also be filled with pus. Blisters that arise from second degree burns typically manifest themselves almost immediately after the skin becomes damaged, whereas those that develop because of first degree burns tend to appear a couple of days after the skin damage.

Blisters are bubbled sacs that are fluid-filled that develop on your skin, and yes, shoes are the most common culprit of these creations. Treating them at home can relieve pain, prevent infection and aid in the healing of large or broken blisters. The doughnut shaped design leaves the area over the blister open to allow air flow to the affected area. Exposure to certain blister agents, such as mustard gas, can lead to severe and large blisters. Hydrocolloid dressings, which can be bought OTC (over the counter) in pharmacies, help protect the burst blister from infection. If not treated promptly and properly, blisters can become a much bigger issue in the long term.
Anyway, this most often results in the blister staying intact, but with significantly less pain later on, and the blister skin still protects the more tender skin beneath the blister, but you don't have the pressure from the fluid build up anymore.
Tender skin that is exposed to friction, heat, dirt and moisture is very vulnerable for developing foot blisters. Even with proper fitting shoes, rubbing and friction associated with a lot of walking, may be inevitable causes. Should this happen you may notice draining of pus from foot blisters, reddened streaks spreading outward and possibly a fever.
You are at a greater risk for developing foot blisters when your socks stick to your skin as a result of perspiration.

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