Diabetics and individuals with impaired circulation should not self-treat blisters, but need to seek professional care.
Blisters are usually caused by excessive friction when running, your first port of call may just be a couple of days rest. Zinc Oxide tape is very useful – if the blister is still healing then place a plaster or gauze dressing over it then tape on top. Compeed Blister Plasters are a good option – they expand in response to friction to protect the area. With any wound there is a risk of infection, with a blister this can delay healing, increase pain and could see you facing a couple of weeks off running. It may be that the blister is so large that the pressure build up is painful and you feel you really need to pop it. When dressing a burst blister don’t remove the surrounding skin (this process is called de-roofing) as it protects the healing skin underneath. If you simply return to running in the same shoes after a blister has formed there’s every chance it could recurr.
Friction combined with excessive moisture sets up the right combination for blister formation.

Calvin Coolidge's nearly 16 year old son developed a blister on his big toe reportedly after playing tennis on the south lawn in shoes while not wearing socks. Skin heals quickly so if you can re-arrange your running schedule a little, you’ll probably find it will have healed enough by the time you run again.
I’ve been using it for years and year, and that, combined with well fitting shoes and socks with ZERO cotton content mean I hardly ever get blisters from running (blisters from sparkly girl shoes are a totally other story!). Several days later the blister became infected, he developed septicemia and died within the week. I recommend getting a packaged sterile needle from a pharmacy and using that to puncture a blister, if necessary. If you need to continue running make sure you reduce friction as much as possible and dress the blister properly. I’ve tried anything from ?2 a pair from the bargain bin to ?15 high tech ones that supposedly prevent blisters, wick sweat and occasionally complement you on your dress sense. The general rule, and safest option is not to burst a blister and to seek medical advice if a blister is very painful or shows signs of infection. You may choose to burst a blister in order to continue running, if so you do this at your own risk and you should dress the wound afterwards and keep it clean.

Sometimes you will need to have a blister punctured to reduce pressure on the underlying skin. If you can rest from running for a few days and just let it settle this is often the most simple and safest approach. Doing lots of hill work can also cause blisters, especially on the toes as they move forward in the shoe as you run downhill. I do however know runners, and there is little chance they’d see their GP about a blister!
If you do choose to pop your blister at home then wash the foot thoroughly first and use a sterile needle.

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