If the blister is in an area where pressure is applied, such as on the bottom of your foot, protect it with a doughnut-shaped moleskin pad. Prevention of diabetic foot infections and early ulcer interventions are the key to preventing amputation, says Dereck Hunt of McMaster University in Hamilton, Ontario, in writing a clinical review for the journal American Family Physician.
The good news is that roughly half of all lower limb amputations can be prevented through proper foot care. The exception -- if a blister is in an area where it might get rubbed, such as on the sole of the foot.
Diabetic patients should be aware of the risks associated with any foot injury and wear therapeutic footwear that offloads pressure. In addition to performing daily cleanses and foot inspections, we feel it is extremely important to limit the amount of pathogens you’re exposed to. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health.
The SteriShoe UV shoe sanitizer is a clinically proven, podiatrist-recommended device that kills up to 99.9% of fungi, bacteria, and viruses in just one 45-minute treatment. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site.
For a broken blister that has drained, protect it from infection by covering it with a bandage. Never ignore professional veterinary advice in seeking treatment because of something you have read on the WebMD Site.

Once a deep blister erupts into a wound, all the bacteria, fungi, and viruses on your feet have an entryway into the body. Keep your feet happy and healthy -- learn the symptoms of common foot problems and what you can do to treat them. Those are the kinds of things that could cause a friction blister on your heel, toe, thumb, or palm. Contact DermatitisRub up against a pesky plant like poison ivy, and you might end up with blisters of another sort. It usually affects the large joint of the big toe, but it also can flare in the foot, ankle, or knees. Scabies are tiny mites that drill into your skin, sometimes leaving curved lines of blisters in their tracks.
The brown recluse spider has an extra-nasty bite that blisters before bursting to form a painful open sore.
Hand-Foot-and-Mouth DiseaseHand-foot-and-mouth disease causes a fever along with blisters on the inside of the mouth, the palms of the hands, the buttocks, and the soles of the feet.
Athlete's FootThis fungal infection can cause peeling, redness, itching, burning, and sometimes blisters and sores. Herpes SimplexFever blisters on your lips, mouth, or genitals are a sign of the herpes simplex virus.
If you have fever blisters or you think you've been exposed to herpes, talk to your doctor.

Hand-Foot-and-Mouth DiseaseThis disease is named after the blisters it causes on these body parts.
For mild cases, soak your foot in warm water, keep it clean, and wedge a small piece of cotton under the corner of the ingrown nail to lift it off the skin. Cover it with a bandage to keep it clean during the day, but take the bandage off at night to let it dry When to See Your DoctorGo to the doctor if you have a fever, chills, or other flu-like symptoms at the same time you have blisters. Other symptoms of infection can include: pain, swelling, redness or warmth, red streaks leading away from your blister, or pus coming from it.
Whooping Cough (Pertussis)Whooping cough makes children cough so hard, they run out of breath and inhale with a "whoop." The infection is most severe in infants and may require hospital treatment. Antibiotics are not especially helpful in treatment, so vaccination is essential for prevention. Without treatment, any strep infection can lead to rheumatic fever and, in rare cases, heart damage. It most commonly causes clusters of tiny blisters on the skin that ooze and form a golden crust.

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