Necrotizing fasciitis (NF) is a relatively uncommon but potentially fatal infection involving the subcutaneous tissue and fascia, a sheet of fibrous or tendinous tissue that lies deep to the skin or covers muscles and various body organs.
Necrotizing fasciitis has been subdivided into type I, or polymicrobial necrotizing fasciitis, and type II, or invasive group A streptococcal necrotizing fasciitis. One of the three particularly feared types of group A streptococcal infections along with myositis and streptococcal toxic shock syndrome, necrotizing fasciitis has a high mortality (up to 40 percent). In dogs necrotizing fasciitis is similar to the disease caused by Streptococcus pyogenes in humans.

Later, systemic toxicity develops, and definitive evidence of necrotizing fasciitis appears. Reports of rapidly progressive and fatal necrotizing fasciitis caused by Streptococcus canis,Staphylococcus pseudintermedius, and E. Necrotising fasciitis and necrotising myositis are rare but serious life threatening conditions reported mainly in human beings and dogs.
When necrotizing fasciitis is localized to the lower abdominal wall, perineum, or genitals, it is called Fournier gangrene.

Necrotizing fasciitis due to Vibrio vulnificus may result in overwhelming sepsis, leading to death in some patients.

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