CAUTION:
Federal (US) law restricts this drug to use by
or on the order of a licensed veterinarian.
BRIEF SUMMARY:
Please consult package insert for complete
product information.
Indications:
For use in dogs to prevent canine heartworm
disease by eliminating the tissue stage of heartworm larvae
(
Dirofilaria immitis) for a month (30 days) after infection and
for the treatment and control of roundworms (Toxocara canis,
Toxascaris leonina), hookworms (Ancylostoma caninum,
Uncinaria stenocephala,Ancylostoma braziliense), and
tapeworms (Dipylidium caninum,Taenia pisiformis).
WARNINGS:
For use in dogs only. Keep this and all drugs out
of reach of children. In safety studies, testicular hypoplasia
was observed in some dogs receiving 3 and 5 times the
maximum recommended dose monthly for 6 months (see
Animal Safety). In case of ingestion by humans, clients should
be advised to contact a physician immediately. Physicians
may contact a Poison Control Center for advice concerning
cases of ingestion by humans.
PRECAUTIONS:
Use with caution in sick, debilitated, or
underweight animals and dogs weighing less than 10 lbs.
The safe use of this drug has not been evaluated in pregnant
or lactating bitches.
All dogs should be tested for existing heartworm infection before
starting treatment with IVERHART MAX
®
Chewable Tablets,
which are not effective against adult D. immitis. Infected dogs
should be treated to remove adult heartworms and microfilariae
before initiating a heartworm prevention program.
While some microfilariae may be killed by the ivermectin in
IVERHART MAX Chewable Tablets at the recommended dose
level, IVERHART MAX Chewable Tablets are not effective for
microfilariae clearance.A mild hypersensitivity-type reaction,
presumably due to dead or dying microfilariae and particularly
involving transient diarrhea, has been observed in clinical trials
with ivermectin alone after treatment of some dogs that have
circulating microfilariae.
ADVERSE REACTIONS:
In clinical field trials with ivermectin/
pyrantel pamoate, vomiting or diarrhea within 24 hours of
dosing was rarely observed (1.1% of administered doses).
The following adverse reactions have been reported following
the use of ivermectin: depression/lethargy, vomiting, anorexia,
diarrhea, mydriasis, ataxia, staggering, conavulsions and
hypersalivation.
ANIMAL SAFETY:
Studies with ivermectin indicate that certain
dogs of the Collie breed are more sensitive to the effects of
ivermectin administered at elevated dose levels (more than
16
times the target use level of 6 mcg/kg) than dogs of other
breeds.At elevated doses, sensitive dogs showed adverse
reactions which included mydriasis, depression, ataxia,
tremors, drooling, paresis, recumbency, excitability, stupor,
coma and death. No signs of toxicity were seen at 10 times the
recommended dose (27.2 mcg/lb) in sensitive Collies. Results
of these studies and bioequivalence studies support the safety
of ivermectin products in dogs, including Collies, when used
as recommended by the label. In a laboratory safety study,
12-
week-old Beagle puppies receiving 3 and 5 times the
recommended dose once weekly for 13 weeks demonstrated
a dose-related decrease in testicular maturation compared
to controls.
HOW SUPPLIED:
IVERHART MAX Chewable Tablets are
available in four dosage strengths (see
Dosage
section)
for dogs of different weights. Each strength comes in a box
of 6 chewable tablets and in a box of 12 chewable tablets,
packed 10 boxes per display box.
STORAGE CONDITIONS:
Store at controlled room temperature
of 59°-86° F (15°-30° C). Protect product from light.
For technical assistance or to report adverse drug reactions,
please call 1-800-338-3659.
Manufactured by:
Virbac AH, Inc. Fort Worth,TX 76137
NADA 141-257,Approved by FDA
IVERHART MAX is a registered trademark
of Virbac Corporation in the US.
© 2013 Virbac AH, Inc. All Rights Reserved. IVERHART MAX is
a registered trademark of Virbac Corporation in the US. 1/12
13446
References: 1.
AmericanAnimal HospitalAssociation.Heartworm prevention on the decline.Available at:http://www.aahanet.org/
blog/NewStat/post/2012/03/21/429406/Heartworm-prevention-on-the-de.aspx.Accessed November 29, 2012.
2.
National
Weather Service Climate Prediction Center. Prognostic discussion for long-lead seasonal outlooks. Available at:
November 29, 2012.
3.
American
Heartworm Society. Canine guidelines summary.Available at:
guidelines-summary.html.Accessed November 29, 2012.
4.
Gates MC, Nolan TJ. Endoparasite prevalence and recurrence
across different age groups of dogs and cats. Vet Parasitol. 2009;166(1–2):153–158.
5.
Blagburn B, Lindsay D,Vaughn J, et al.
Prevalence of canine parasites based on fecal flotation. Compendium. 1996;18(5):484.
6.
Data on file,Virbac Animal Health.
7.
Companion Animal Parasite Council (CAPC). CAPC recommendations for parasite prevention and control: intestinal parasites
–
cyclophyllidean tapeworm. 2011.Available at:
Accessed November 30, 2012.
Sponsored by
A DECLINE IN HEARTWORM PREVENTION AND
WARMER WINTERS CAN SPELL DOUBLE TROUBLE.
According to the American Animal Hospital
Association, only 36% of all canine patients
received at least 1 dose of heartworm
preventive in 2011.
1
To make matters worse, after the warm
winter of 2011–2012, the National Weather
Service has predicted above-normal
temperatures for much of the western US,
stretching across the Central Plains to the
western Gulf Coast.
2
In mild weather, mosquitoes have more
opportunity to cause heartworm infection
in pets. But even in cold winters, pets can
be at risk for heartworm disease because:
Pets are traveling to warmer climate
where mosquitoes are abundant
Mosquitoes survive in warm, indoor
microclimates during the winter months
There is room for error in timing seasonal
heartworm prevention, since weather
conditions can vary widely from year
to year, and it only takes 1 mosquito
to infect a pet
It is for these reasons that the American
Heartworm Society recommends year-round
heartworm disease prevention for dogs.
3
Tapeworms may be on the rise, too.
Recent data suggest that tapeworm
prevalence in dogs is greatly underdiagnosed:
1%
OR LESS
—
Generally accepted
prevalence using fecal exams.
4,5
7.1%
—
Prevalence found in a study
involving 550 shelter dogs in the Southeast
by fecal centrifugation/flotation on samples
collected 18 to 24 hours after treatment
with praziquantel.
6
45.5%
—
Average prevalence found in
an ongoing study in which fecal specimens
from 1,789 pet dogs were examined using
enzyme-linked immunosorbent assay
(
ELISA) testing to detect tapeworms.
6
Kill 2 worms with 1 tablet.
The Companion Animal Parasite Council
(
CAPC) recommends a heartworm
preventative containing praziquantel to
routinely treat infections caused by 2 of
the most common tapeworms in dogs,
Dipylidium caninum and Taenia pisiformis.
7
IVERHART MAX
®
(
ivermectin/pyrantel
pamoate/praziquantel) Chewable Tablets
can help prevent nasty tapeworm surprises
for dog owners as well as heartworm
disease in dogs. Learn more at
All dogs should be tested for heartworm
infection before starting a preventive program.
Following use of IVERHART MAX Chewable
Tablets, digestive and neurological side
effects have rarely been reported. Use with
caution in sick, debilitated, or underweight
animals and dogs weighing less than 10 lbs.
See brief summary for additional details.
(
ivermectin
/
pyrantel pamoate
/
praziquantel
)
To learn more, scan
the code with your
smartphone or visit
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