How does an incretin-based diabetes treatment differ from other treatments for type 2 diabetes? First, they address one of the underlying problems of type 2 diabetes by directly working on the beta cell.  Because of this, drugs like Victoza® have a major ability to lower glucose concentrations. Second, since their action depends on the level of glucose in the blood, they have a very low risk of causing low blood sugar (hypoglycemia) which distinguishes them from some other commonly used diabetes medications. Third, and unlike most other diabetes medications, they do not increase weight.  And Victoza actually promotes weight loss. What symptoms would suggest the use of incretin-based treatment?  Is it (or could it be) used as a first line treatment? For the studies that indicated patients lost weight as a result of taking Victoza, how long were patients followed? What about Victoza as a weight loss drug in non-diabetics?  Are there studies planned for that? Your safety information states that Victoza has been found to cause thyroid tumors in some rats and mice and that it is unknown whether this could be the case in humans as well.  What are the benefits of Victoza that outweigh such a potentially heavy risk?
The drug warnings for Victoza note that in clinical trials, at least 8.6% of patients treated with Victoza developed anti-liraglutide antibodies (in other words, anti-Victoza antibodies). Given the risk seen in these studies of developing antibodies against both native and analog GLP-1, are there any symptoms or warning signs that patients taking Victoza should look out for that would indicate they were developing an autoimmune reaction to the drug?
He has written over 100 papers and articles on the treatment of diabetes, is an Editor of the Fourteenth edition of Joslin’s Diabetes Mellitus, and has been recognized both locally and nationally for clinical care in diabetes and for his research in diabetes and growth factors.
My husband was given a sample of Victoza and used it one day until we learned it was no tested with patients currently on insulin.
The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes.
High blood glucose levels can damage the delicate blood vessels in your retina, and affect the shape of your eye’s lens, temporarily causing blurry vision, according to the American Diabetes Association. Each year, visit your ophthalmologist for a comprehensive eye exam that includes a glaucoma test, a cataract test, and a dilated eye exam. Smoking has a harmful effect on every body’s system, especially people with diabetes, and the eyes are no exception. Exercising regularly can help improve glycemic control, one of the contributing factors in determining how likely you are to develop eye damage related to diabetes. Protecting your eyes can start with eating a well-balanced diet including vitamin A, vitamin C, vitamin E, beta-carotene, omega-3 fatty acids, lutein, zeaxanthin, and zinc can help reduce the risk of developing cataract and macular degeneration. Naomi Ruperto, also known as The Diabetic Diva®, was diagnosed with diabetes at the age of 12. Bigfoot was founded by Jeffrey Brewer, former CEO of JDRF International, and Bryan Mazlish, the mysterious “Bigfoot” in Dan Hurley’s piece for Wired Magazine, in November 2014, with the sole purpose of revolutionizing the treatment of Type 1 diabetes. Bigfoot recently received approval by the FDA of its Investigational Device Exemption (IDE) submission for a first clinical study of the smartloop automated insulin delivery system.


Una diabetes mal controlada puede danar los pequenos vasos sanguineos de la retina, la parte del ojo que es sensible a la luz y encargada de enviar mensajes al cerebro acerca de lo que se ve. Cuando los vasos sanguineos de la retina se danan, pueden dejar escapar fluido y causar hinchazon dentro de la macula, que es la parte de la retina que permite tener una vision clara y nitida.
Si la retinopatia empeora, el ojo puede comenzar a formar vasos sanguineos nuevos sobre la retina. Cuando la retinopatia se diagnostica a tiempo, el tratamiento con laser puede ayudar al paciente a que no pierda la vista. Unete a Salud180 y al servicio de Alertas para recibir las noticias mas relevantes en tu correo electronico. Alan Moses, Novo Nordisk’s Chief Medical Officer, a few questions about Victoza and its use in the treatment of type 2 diabetes.
Was the weight loss persistent for the course of the study and any follow-ups, or did patients regain weight over time? Yes.  Victoza® is currently in Phase III development for the treatment of obesity in individuals without diabetes, but these studies will take several years to complete. Victoza® is not indicated for the treatment of type 1 diabetes.  Rather, it is approved only for the treatment of type 2 diabetes.
More concerning still, in the 52-week trial, 6.9% of patients treated with Victoza also developed antibodies against native GLP-1. Moses, MD is board certified by the American Board of Internal Medicine and has subspecialty certification in Endocrinology and Metabolism. I would like to know about the safety of the use of this drug along with insulin and if there are any patients who are using this drug safely with their insulin- he is now taking 85 units Lantus along with 2000 mg metformin and 10 glipicide. I have been struggling for 26 years to keep my sugars stable but haven’t had any luck.
While these can be tough discussions to have, I knew it was important to learn the potential impact diabetes could have on my body.
Three common eye diseases of people with diabetes are diabetic retinopathy, glaucoma, and cataracts.
An optional screening test you may want to consider is retinal imaging, which helps detect diseases early and provides a permanent and historical record of changes in your eye so it’s easy to discover even subtle changes in your health year after year. While smoking has not been proven to increase the risk of diabetic retinopathy, it may aggravate many other health problems, including the disease of the small blood vessels. Make an appointment with yourself to exercise at least three times a week for 60 minutes each day, and treat it like a real appointment. Their  mission is expressed in a system of care to transform the lives of people who depend upon the daily administration of insulin, a life-giving but also dangerous drug.
The trial is slated to take place at three sites, each of which is a global leader in closed-loop insulin delivery research. Las paralisis oculares suelen mejorar espontaneamente en la medida en que se recupera el control glucemico.


The most common adverse reactions reported in patients treated with Victoza® are headache, nausea, diarrhea, and anti-liraglutide antibody formation.  Immunogenicity-related events, including urticaria, were more common among Victoza-treated patients than among comparator-treated patients in clinical trials.
The  animal findings mean that Victoza is contraindicated in people who have a history of thyroid C-cell tumors, a very rare condition. Is there a risk that a type 2 diabetic patient treated with synthetic incretins will develop a previously absent autoimmune reaction to native peptides like GLP-1, further impairing insulin production and pancreatic performance?
My eye doctor told me that eyes are one of the first places where you can become aware of diabetes complications, so eye care is always on the top of my list. Diabetic retinopathy is the weakening of the tiny blood vessels in the retina, glaucoma is the buildup of pressure in the eye, and cataracts is the clouding of the lens, which can permanently blur your vision.
Yearly eye screenings allows you to begin treatment as soon as possible if signs do appear. UVA exposure can contribute to cataracts and macular degeneration, so always shield your eyes from the sun with UVA and UVB sunglasses. Equally important, people with diabetes have an increased risk of developing a stroke or heart attack, and smoking can significantly raise that risk.
If you’re just starting an exercise routine, start out slowly by walking 20-30 minutes a day. Moving with unprecedented speed in medical device development, over the past 20 months they’ve assembled a team of 40 people and are driving toward commercialization of a cutting edge approach to improving the lives of people with T1D. La posibilidad de que se forme tejido cicatrizal derivaria en que la retina se desprendiera de la parte posterior del ojo. The nausea that occurs with Victoza is relatively mild in intensity and disappears quite rapidly after starting treatment. Whether you’re a smoker and have tried to quit, or want to quit for the first time, don’t give up. You can break this up into two 15 minute sessions if it works better with your schedule, too.
Moses joined Novo Nordisk, Inc as Associate Vice President for Clinical Research and Medical Affairs – Endocrinology and in 2007 was named Chief Medical Officer, North America. In January of 2008, he was named Corporate Vice President and Global Chief Medical Officer.
In this role, he is involved in the full spectrum of the diabetes focus of Novo Nordisk from drug discovery, through drug development, brand messaging, and the implications of diabetes for the company and for patients, healthcare professionals and for healthcare systems.



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