A Chinese medicine that combines prescription diabetes medication Glibenclamide with traditional herbs may offer a lower risk of episodes of hypoglycemia (low blood sugar) than the Glibenclamide given alone. A typical list of the Chinese herbs included in the mix is radix astragali, radix rehmanniae, and radix trichosanthis. For instance, WebMD said that the first two herbs were used to support the immune system in general and to treat fatigue and diabetes in particular — but there was no scientific evidence that they worked.
And Chinese medicine has certainly received some bad publicity this month, with its use of elephant tusks and scaly anteaters threatening the survival of whole populations of wildlife. However, it’s reasonable to assume that at least some traditional remedies were based on actual results observed by healers over the centuries. Xiaoke, like bitter melon, could be a plant-based traditional Chinese medicine that does no harm and may do some good. Side effects: Possible side effects include peripheral edema (fluid buildup and swelling in the legs, hands, or feet), low blood sugar (especially if you are also taking insulin, glyburide, glipizide, or glimepiride), headache, upper respiratory tract infection, or urinary tract infection. Use it at the gym, running, playing, or anywhere you might need to have emergency information easily available. Durable and stylish, the MyID™ band is always ready to provide information when you can't. Enter your email address to follow this blog and receive notifications of new posts by email. Approval is the first under firms’ global diabetes alliance for late-stage product development.


FDA has approved Boehringer Ingelheim and Eli Lilly’s linagliptin tablets for the treatment of type 2 diabetes alongside diet and exercise measures.
The firms’ diabetes alliance is focused on developing and commercializing a portfolio of diabetes compounds currently in mid- and late-stage development.
Boehringer Ingelheim’s BI10773 is a sodium-dependent glucose co-transporter-2 (SGLT-2) inhibitor, which started in Phase III clinical trials in 2010. Join 110,000 colleagues who rely on GEN Highlights for breaking news and exclusive articles shaping today’s life science tools and technologies.
That’s the result of a study of 800 patients performed by a large research team in China, which was reviewed by another team in Australia and then recently published in the open access journal PLOS One. Despite their long history in China, Western medicine has had little evidence of their effectiveness.
For instance, a recent study on bitter melon has revealed that it probably does have an ingredient that fights pancreatic cancer. Approval covers use of the once-daily dipeptidyl peptidase-4 inhibitor either as monotherapy or in combination with other type 2 diabetes drugs including metformin, sulphonylurea, and pioglitazone, for reducing HbA1c levels. Lilly will be eligible to receive up to a total of $650 million in success-based regulatory milestones on its two basal insulin analogues. Lilly’s two basal insulin analogue candidates are expected to enter Phase III clinical testing in 2011.


Three placebo-controlled studies evaluated linagliptin either as monotherapy or in combination with oral metformin and sulphonylurea in patients whose blood sugar was not adequately controlled on either of the latter two drugs.
The deal also includes an option to co-develop and co-commercialize Lilly’s Phase II-stage anti-TGF-beta monoclonal antibody.
If Boehringer Ingelheim decides to opt-in to Phase III development and potential commercialization of the anti-TGF-beta monoclonal antibody, Lilly would be eligible for up to $525 million in opt-in and success-based regulatory milestone payments. LY2605541 is a structurally novel basal insulin analogue, and LY2963016 is a new insulin glargine product. The studies confirmed linagliptin significantly reduced HbA1c levels when used as monotherapy and when added to the existing diabetes treatments. A fourth study confirmed that adding linagliptin to pioglitazone therapy reduced HbA1c levels to a greater extent than pioglitazone monotherapy.



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