Diabetes is a lifelong chronic disease that is caused by high levels of sugar in the blood.
When it comes to your feet, there are several risk factors that can increase your chances of developing foot problems and diabetic infections in the legs and feet. People who have long-standing or poorly controlled diabetes are also at risk for having damage to the nerves in their feet, which is known in the medical community as peripheral neuropathy.
Normal nerves allow people to sense if their shoes are too tight or if their shoes are rubbing on the feet too much. A recent study released from the School of Medicine at Boston University revealed the benefits of Vitamin D are greater than previously thought. The PLOS ONE study was a double-blind, randomized trial that involved eight men and women who were healthy, and at a median age of 27. Results were statistically significant, showing that vitamin D greatly altered activity in 291 genes. As a fat-soluble vitamin that is produced when ultraviolet rays from sunlight are exposed to the skin and trigger vitamin D synthesis, vitamin D promotes calcium absorption.
There are other vitamin D analogues, as well as calcitriol that LGM Pharma provides for research and development purposes. Products currently covered by valid US Patents are offered for R&D use in accordance with 35 USC 271(e)+A13(1).
This entry was posted in Drug Research & Development API and tagged vitamin D by admin. It can also decrease your body’s ability to fight off infections, which is especially harmful in your feet.
Normal sweat secretion and oil production that lubricates the skin of the foot is impaired, which can lead to an abnormal pressure on the skin, bones, and joints of the foot during walking and other activities. First of all, poorly fitting shoes are one of the biggest culprits of diabetic foot complications.

If you have nerve damage, you may not be able to feel your feet normally and you may also be unable to sense the position of your feet and toes while walking and balancing, which can cause even more harm to your feet. With diabetes, you may not be able to properly sense minor injuries, such as cuts, scrapes and blisters-all signs of abnormal wear, tear, and foot strain. You can avoid serious problems such as losing a toe, foot, or leg by following proper prevention techniques offered by your podiatrist.
The study, coined PLOS ONE, demonstrated there are considerable benefits of vitamin D for healthy adults. All eight participants were either deficient in vitamin D or had insufficient levels at the start of the trial.
These 291 genes were shown to be related to 160 biologic pathways, which were linked to autoimmune diseases, cancer, infectious diseases and cardiovascular disease. Whether vitamin D is obtained from either sunlight, food or supplements, it is biologically inert. Clients can be assured of quality API products and continuous support throughout the R&D process.
When diabetes is not properly controlled, damage can occur to the organs and impairment of the immune system is also likely to occur. This can even lead to the breakdown of the skin of the foot, which often causes sores to develop. If you have red spots, sore spots, blisters, corns, calluses, or consistent pain associated with wearing shoes, new proper fitted shoes must be obtained immediately.
Three of the participants were dosed with 400 International Units of vitamin D daily and five participants were dosed with 2,000 IUs daily. If you have diabetes, it is important to prevent foot problems before they occur, recognize problems early, and seek the right treatment when a problem does happen.
Additionally, if you have common foot abnormalities such as flat feet, bunions, or hammertoes, prescription shoes or orthotics from your podiatrist may be necessary to further protect your feet from other damage.

The first hydroxylation happens in the liver which converts vitamin D to 25-hydroxyvitamin D, known as Calcifediol, CAS# 19356-17-3. The PLOS ONE study touted the improvement by showing how increasing the vitamin D status in healthy adults leads to a significant genetic impact. The patients had samples of their white blood cells collected at the beginning of the study, and again at the culmination of the two month study.
These genes were involved with several biologic pathways that are associated with infectious diseases, autoimmune diseases, cancer and cardiovascular diseases.
Calcitriol is a calcium regulator which increases blood calcium levels by promoting the absorption of dietary calcium from the gastrointestinal tract.
Studies previously completed revealed that patients with deficiencies in vitamin D had a greater risk of carrying genetic diseases.
Calcitriol additionally aids the body in increasing the reabsorption of calcium, therefore reducing the loss of calcium in the urine. This study further establishes this link by offering scientific evidence that improving one’s vitamin D levels truly does lower the risk for several diseases.
Bone cells referred to as osteoclasts are stimulated via this release of calcium from the bone when patients take calcitriol, and the intestinal absorption of both calcium and phosphorus is increased as well.
Providers should be aware of potential presentation of symptoms from patients, such as nausea, vomiting, anorexia, headache, sweating, and polyuria. Known as the injectable drug Calcijex, marketed by Abbott Laboratories, calcitriol is earmarked for use in the management of hypocalcemia in patients undergoing chronic renal dialysis.

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