The pancreas has many islets that contain insulin-producing beta cells and glucagon-producing alpha cells. Since diabetes is a disease that affects your body's ability to use glucose, let's start by looking at what glucose is and how your body controls it. When you eat food, glucose gets absorbed from your intestines and distributed by the bloodstream to all of the cells in your body. To maintain a constant blood-glucose level, your body relies on two hormones produced in the pancreas that have opposite actions: insulin and glucagon. Insulin is made and secreted by the beta cells of the pancreatic islets, small islands of endocrine cells in the pancreas.
As such, insulin stores nutrients right after a meal by reducing the concentrations of glucose, fatty acids and amino acids in the bloodstream. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Diabetes Mellitus Complications Diabetes is a serious disease and you should not be lulled into thinking that having diabetes is “no big deal.” Complications of diabetes mellitus are not only life threatening, but life altering. Clipping is a handy way to collect and organize the most important slides from a presentation.
The condition of gangrene is a serious one, primarily marked by loss of adequate supply of blood to the tissues of the body, ultimately resulting in its necrosis or death. Injury to the tissues, infection (mostly of bacterial origin) and presence of any underlying health ailment that inflicts damage to the blood carrying vessel structure form the three key underlying mechanisms that are responsible for initiation and development of irreversible tissue damage and life threatening condition of gangrene.
As already explained, one of the causes of gangrene in the toes and fingers is linked with damaged blood vessels. High level of blood glucose associated with diabetes mellitus also damages the nerves (known as peripheral neuropathy), especially the nerves in the lower extremities. The dullness or lack of sensation puts diabetic individuals at an increased risk of injuring the skin of their fingers or feet without having any realization (it mostly goes unnoticed in the feet region). The sore or foot ulcer formed takes an extended time to heal because of both, poor circulation of blood through the injured area as well as lesser number of defence cells.
Bacterial infection also forms another causative factor that makes the diabetic individual more prone to developing gangrene. Such type of infection is marked by noticeable skin discolouration and dryness along with the formation of skin blisters. The weakened immune system (seen in diabetes) further raises the risk of incurring serious infection, which later develops, into gangrene. We use cookies to enhance your visit to our site and to bring you advertisements that might interest you.
The Home Secretary was diagnosed with Type 1 diabetes two months ago and must now inject herself with insulin at least twice a day for the rest of her life, the Mail on Sunday revealed. Click here to view instructions on how to disable your ad blocker, and help us to keep providing you with free-thinking journalism - for free. On Adblock Plus click "Enabled on this site" to disable ad blocking for the current website you are on.


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The previously approved G4 Platinum System is for insertion of the sensor in the abdomen only. The device system components (sensor and transmitter) are unmodified from the previous system. Before the approval, the FDA reviewed data from a pivotal clinical study of in-clinic and home-use patients to assess the accuracy and precision of the system. The pivotal clinical study demonstrated that the G4 Platinum (Pediatric) System performance in pediatric subjects was not as accurate as the performance of the same device in adults. In a pediatric clinical study, larger differences were observed between this CGM device and actual blood glucose values compared to those differences observed in the adult clinical study. In a pediatric clinical study, a significant number of low glucose events were not detected by CGM. Research on CGMs is underway as part of a developmental artificial pancreas device system (APDS) for people with type 1 diabetes, a device that includes a CGM and an insulin pump.
The Diabetes Media Foundation is a 501(c)(3) tax-exempt nonprofit media organization devoted to informing, educating, and generating community around living a healthy life with diabetes. Your body tries to keep a constant supply of glucose for your cells by maintaining a constant glucose concentration in your blood -- otherwise, your cells would have more than enough glucose right after a meal and starve in between meals and overnight.
Diabetes Mellitus complications are not an inevitable part of diabetes if you know how to reverse your diabetes.
FACT: 75% of all deaths related to diabetes are caused by a heart attack or another form of heart disease. High blood sugar can injure nerve fibers throughout your body, but diabetic neuropathy most often damages nerves in your legs and feet.” When loss of feeling occurs in the feet and legs a sore or cut may go unchecked. Death of cell and tissue may target any part of the body, however, it has been typically observed in the extremities, such as the toes, fingers and hands.
In both, type 1 and type 2 diabetes, the raised level of sugar is capable of causing damage to the blood vessels and reducing blood supply. Owing to the nerve damage, the transmission of sensation, particularly those of pain to the brain gets impaired. A notorious bacterial organism, Clostridium perfringes is often linked with gas gangrene; after it attacks the site of injury or sometimes, surgical wound.
It helps to build our international editorial team, from war correspondents to investigative reporters, commentators to critics. FDA has approved the expanded use of the Dexcom G4 Platinum Continuous Glucose Monitoring System for patients with diabetes ages 2 to 17 years.


The new Dexcom G4 Platinum (Pediatric) System includes the upper buttock in addition to the abdomen as sensor insertion sites.
One hundred and seventy-six patients ages 2 to 17 wore the G4 Platinum (Pediatric) sensor for seven days (168 hours). In addition, the performance of the hypoglycemic detection alert in the pediatric study was poor relative to that seen in the adult study, particularly at blood glucose concentrations below 70 milligrams per deciliter of blood. An artificial pancreas system would monitor glucose levels and automatically pump the appropriate amount of insulin as determined by a computer algorithm.
The cells take in glucose from the blood and break it down for energy (some cells, like brain cells and red blood cells, rely solely on glucose for fuel). So, when you have an oversupply of glucose, your body stores the excess in the liver and muscles by making glycogen, long chains of glucose.
Insulin is required by almost all of the body's cells, but its major targets are liver cells, fat cells and muscle cells. This loss of pain sensation coupled with a decrease in blood flow to the feet and legs can lead to diabetic ulcers which can be very hard to heal often leading to amputation of toes, feet or part of the leg. In the absence of a continuous supply of nutrient and oxygen rich blood, the cells within the body begin to fail in carrying out their normal function and finally give up. As a result of restricted blood circulation to the extremities, such as the feet, the area becomes deprived of those cells (white blood cells) which aid in fighting off any infection. And Dexcom G4 PLATINUM (Pediatric) is the first CGM device approved for persons with diabetes in the 2-6 age-range and the only CGM device that offers an alternate sensor wear site on the upper buttocks for added flexibility. Neuropathy can also cause tingling, burning or pain that begins at the tips of the toes or fingers and slowly spreads upward.
Swelling and inflammation resulting from the infection causes the local temperature of the area involved to be slightly elevated, and also leads to pain. In a recent study half of diabetes patients participating received drugs to lower their systolic blood pressure to 120 and this failed to prevent heart attacks and heart related deaths.
I'm a little more careful about what I eat and there's obviously the injections, but this is something millions of people have .
I'm OK with needles, fortunately."There's a great quote from Steve Redgrave who was diagnosed with diabetes before he won his last Olympic gold medal.



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