In this study the research team wanted to understand how dietary restriction impacts autophagy in the intestine, whose proper function is already known to be important for long life.
The research team also observed that turning off autophagy in the intestine made the slow-eating, long-lived worms move around less. This site complies with the HONcode standard for trustworthy health information: verify here.
A new study from the Sanford Burnham Prebys Medical Discovery Institute (SBP), published today in PLoS Genetics, represents a major advance in understanding how dietary restriction leads to these advantages. We found that while normal worms' gut barriers become leaky as they get older, those of eat-2 worms remain intact.
This both eliminates unnecessary or broken cell machinery and provides building blocks to make new cell components, which is especially important when starting materials are not provided by the diet.
The knowledge we gain from this fast-paced research could eventually contribute to the development of new treatments that help people live longer, healthier lives," added Hansen.
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