Illegal drugs are harmful for the human body and the worst affected part of the body is brain.
The things that a drug user sees, feels, hears, touches and smells run together in the brain. When people think that they need an illegal drug to feel better emotionally, it is called emotional dependence and when they believe that they need illegal drugs to feel better physically it is physical depend. Take the pill only when required that is prior to sexual interaction to achieve the hard erection. If by chance you have overdosed with Sildenafil citrate it can cause the priapism (it means erection for prolong time which can be painful); other symptoms that can be felt are nausea, chest pains and irregular heartbeat. Other miserable symptoms were akathisia, a severe form of inner restlessness, often driving patients to walk anxiously in circles, and dystonia, a muscle tension disorder manifesting in strong, uncontrollable muscle contractions.
This pill helps the man in getting proper erection to have successful physical intercourse with the partner. It makes the dilation of the blood vessel through the release of the nitric oxide that is a vasodilator and another component cyclic guanosine monophosphate (cGMP). With the sexual arousal, the action of the drug is triggered and causes the filling of the penile area with blood and causes the erection. These are chest pain, slow heartbeat, swelling of the lips, tongue or face, swelling of legs and ankle, diarrhea, dizziness, sensation of nausea, severe headache, sensation of vomiting, itching. Drug abusers build tolerance to the illegal drugs when they take these drugs over a long time. Its efficacy and safe clinical profile--safe from EPS, that is--were confirmed in clinical studies in the 60s and early 70s. A drug abuser has to increase the amount of drug every time to have the same feelings that smaller amounts once caused.
The drug abuser has to keep on adding amounts and a time comes when the amounts can become very dangerous for the human body. An amount of an illegal drug large enough to cause great harm to the body or even it leads to death, it is called overdose. First time, the drug abuser does not know how much amount can result in an overdose and many people die because of this overdose.
Given that white blood cells are the infection-fighting cells, people with the condition were at a high risk of infection--often serious.
The situation was not satisfactory.Really, that should have been the end of the drug--with a side effect like that, who should be expected to take it?--except that schizophrenia can be so terribly difficult to treat. Likewise, it began the trend of untoward new side effects not fully revealed before approval, which would lead to a steady stream of lawsuits.Several effective, strong medications were developed, free of EPS symptoms.
But accusations of wrong-doing would abound, lawsuits would proliferate, and the Department of Justice would take a stand.
Apparently Sandoz and the Caremark unit of Baxter International operated an illegal tie-in wherein those who took Clozaril had to buy a Caremark blood-monitoring service to cautiously watch out for the drug's possibly legal side effects. In 2003 it was approved to treat bipolar disorder, and in 2005 it was most prescribed antipsychotic in America, with revenue of over $2.1 billion. In the next 7 years loss of patent and the surge of other atypicals would knock Risperdal's earning power significantly.In the meantime this atypical, too, had its problems, as so many would turn out to have. In 2002 Janssen wrote an open letter to Canadian doctors warning of the risks of using Risperdal with elderly patients with dementia.
It underplayed significant weight gain that showed up in clinical trials, a move that would come back to haunt them.The New York Times found that internal documents clearly indicate that, during the clinical trials, 16 percent of people taking Zyprexa gained more than 66 pounds after a year on the drug.
Abilify (the 6th atypical) came in 4th, earning $4,551,769,585, followed hard upon by Seroquel (the fourth atypical) in the number 6 slot, earning $4,349,322,433. Abilify was right ahead of it with $5.2 billion in sales--but that's only because the drug itself costs more.
It was second only to the generic risperidone (formerly Janssen's Risperdal) in treatment of newly diagnosed schizophrenics, with the generic clearly imposing significantly lower cost burden.Abilify seems to have the most FDA approvals, the fewest lawsuits, a huge price tag--and to still be on patent.
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