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Micrograph showing hypertrophic decidual vasculopathy, the histomorphologic correlate of gestational hypertension.
Gestational hypertension or pregnancy-induced hypertension (PIH) is defined as the development of new arterial hypertension in a pregnant woman after 20 weeks gestation without the presence of protein in the urine. This is when tonic-clonic seizures appear in a pregnant woman with high blood pressure and proteinuria.
This is a dangerous combination of three medical conditions: hemolytic anemia, elevated liver enzymes and low platelet count. There is no specific treatment, but is monitored closely to rapidly identify pre-eclampsia and its life-threatening complications (HELLP syndrome and eclampsia). Drug treatment options are limited, as many antihypertensives may negatively affect the fetus. The fetus is at increased risk for a variety of life-threatening conditions, including pulmonary hypoplasia (immature lungs).


Burger D, Schock S, Thompson CS, Montezano AC, Hakim AM, Touyz RM.SourceKidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada. Choi S, Kim JA, Na HY, Kim JE, Park S, Han KH, Kim YJ, Suh SH.SourceDepartment of Physiology Medical School, Ewha Womans University, Seoul 158-710, Republic of Korea. Endothelial dysfunction is associated with K3.1 dysfunction and contributes to the development of hypertension in preeclampsia.
MicroRNA-376c Impairs Transforming Growth Factor-? and Nodal Signaling to Promote Trophoblast Cell Proliferation and Invasion. Fu G, Ye G, Nadeem L, Ji L, Manchanda T, Wang Y, Zhao Y, Qiao J, Wang YL, Lye S, Yang BB, Peng C.SourceDepartment of Biology, York University, 4700 Keele St, Toronto, Ontario, Canada. Preeclampsia is a major disorder of pregnancy and a leading cause of maternal and perinatal morbidity and mortality. Methyldopa, hydralazine, and labetalol are most commonly used for severe pregnancy hypertension.


If the dangerous complications appear after the fetus has reached a point of viability, even though still immature, then an early delivery may be warranted to save the lives of both mother and baby.
However, evidence of endothelial K3.1 dysfunction in the vascular system from women with preeclampsia is still lacking. An appropriate plan for labor and delivery includes selection of a hospital with provisions for advanced life support of newborn babies.



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