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It is more than 99 percent effective; your chances of becoming pregnant during the first year of use are less than 1 in 100.
Depo-Provera works by preventing the release of hormones called gonadotropins from the pituitary gland in the brain.
In medical studies, only 68 percent of women became pregnant within 12 months after stopping Depo-Provera. If you think you will want to get pregnant shortly after you stop using birth control, Depo-Provera may not be the ideal method for you. The amount of time you use Depo-Provera does not affect the delay in becoming pregnant when you stop.How should you take Depo-Provera?Depo-Provera is given by a doctor.
To make sure you are not pregnant when you receive your first injection, it is given only during the first 5 days after your menstrual period, when it is very unlikely that you could be pregnant. If you are breastfeeding, Depo-Provera is given 6 weeks after childbirth to reduce the infant's exposure to the drug through breast milk.

If you are not breastfeeding, it is given within 5 days of childbirth.Depo-Provera must be taken every 3 months (13 weeks), on schedule.
Only your doctor can determine if it is safe for you to continue taking Depo-Provera.By far, the most common side effect of Depo-Provera is unpredictable menstrual bleeding.
For example, when first taking Depo-Provera, it is common to have spotting between menstrual periods, or an increase or decrease in the amount of bleeding when menstrual periods occur. With continued use, many women stop having their menstrual periods altogether.By 12 months (or four injections), 55 percent of women report not having periods, and by 24 months, 68 percent no longer have periods. Bone loss becomes greater the longer Depo-Provera is used, and may not be reversible.Studies of women who have used Depo-Provera for a long time have found virtually no increased risk of cancers of the breast, ovaries, liver, or cervix (mouth of the uterus).
Some studies do show a slight increased risk of breast cancer in women younger than 35 years old who have taken Depo-Provera for a short time, but the increase is about three additional cases of breast cancer per 10,000 women. Check with your doctor before taking aminoglutethimide if you are on Depo-Provera.Special information if you are pregnant or breastfeedingDepo-Provera is not given to pregnant women.

If an unexpected pregnancy occurs 1 to 2 months after a Depo-Provera injection, the baby is more likely to have a low birth weight or other health problems; birth defects are possible if you use the drug during the first 3 months of pregnancy. Children born to women who were taking Depo-Provera show no signs of poor health or development. Because Depo-Provera does not prevent the breasts from producing milk, it can be used by women who are breastfeeding. However, to minimize the amount of Depo-Provera that is passed to the infant during the first weeks of life, the drug is not given until 6 weeks after childbirth.

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