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PGD, preimplantation genetic diagnosis, is the process of removing a cell from an in vitro fertilization embryo for genetic testing before transferring the embryo to the uterus. The term PGD, preimplantation genetic diagnosis, is often loosely used to refer to any testing performed on an embryo prior to it being transferred to the uterus. Check the CDC and SART sites to find an IVF clinic in your area with a good volume of cases and high success rates. There has been some controversy about whether PGD testing of early embryos before transfer will increase the chance of a successful outcome. The overall risk for a chromosomally abnormal live birth does not appear to be increased by having IVF or IVF with ICSI (intracytoplasmic sperm injection). Grading of embryo quality in the IVF lab can help pick the chromosomally normal embryos for transfer.


PGD, preimplantation genetic diagnosis, involves removing a cell from an IVF embryo to test it for a specific genetic condition (cystic fibrosis, for example) before transferring the embryo to the uterus. Data from recent studies using trophectoderm biopsies combined with chromosomal analysis using advanced genetics technologies assessing all 23 chromosomes show very high IVF success rates.
Rather than having IVF with PGS using their eggs, many of these women will need to do IVF with egg donation in order to have a successful pregnancy. PGS, preimplantation genetic screening, is the proper term for testing for overall chromosomal normalcy in embryos.
It is now considered by many experts to be the biopsy procedure of choice for PGD and PGS testing. In general, the best clinics for PGD or PGS will be the clinics with the best IVF success rates.


By having IVF aneuploidy screening of the embryos, they can have chromosomally normal embryos transferred. Also, the skills that lead to successful IVF are the same skills that facilitate blastocyst culture, embryo biopsy and blastocyst vitrification (freezing) and successful frozen-thawed embryo transfers.



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