Chances of getting pregnant after 40 years old 3.b?l?m,need help getting pregnant with pcos risks,due date calculator based on last period and cycle length - Tips For You

The essentials of Assisted Reproductive Medicine are to achieve MAXIMUM success of each individual situation.
As a first step, IUI may be recommended to young women (up to 36 years of age) with the option of 3 to 6 cycles. A Polycystic Ovary Syndrome (PCOS) often is the underlying cause when the desire for children remains unfulfilled. Subsequently, ovulation will be triggered by injecting human chorionic gonadotropin (hCG) and the semen is placed into the uterine cavity. To appropriately prepare the inner lining (endometrium) of the uterus for implantation, certain hormones (e.g. Since 1978 in vitro fertilization and subsequent transfer of the embryo are available to treat infertile couples, even in case of tubal blockage, various conditions of hormonal imbalance or if male factors (lack of mobile sperm in the semen or poor sperm quality) account for infertility. Basically, "In Vitro Fertilization" or "Extra-Corporal Fertilization" refers to the fusion of ovum and sperm outside a woman's body.
This is done by removing the oocyte from the ovary and subsequently joining it with the man’s sperm in a petri dish (= in vitro).
Two to five days later the subsequently obtained embryo will then be transferred to the uterine cavity (embryo-transfer). The couple has to be informed about all details and aspects of the various treatment options. After a preliminary consultation each couple is given a leaflet and therapy plan with detailed description of each examination (ultrasound scans, hormonal assessments, blood tests etc.) as well as details on the medication. To meet each couple’s individual needs, the treatment is tailored to the particular situation involved in every single case. Until 1996 embryos used to be placed into the uterus (embryo transfer) 2 – 3 days after follicle puncture with the embryo consisting of 4 – 8 cells.
Today, at our IVF Centers embryo transfer is almost only performed at the blastocyst stage. Only about three out of an average of 12 egg cells produced within one year by a woman having a regular menstrual cycle (an ovulation each month = 12 ovulations per year) are capable of developing into a child after fertilization. In theory, almost all 12 oocytes could develop up to day 3 (including those not leading to pregnancy), even though they have never met a sperm. Frequently, these eggs do not have enough energy supplies in order to activate the sperm on day 3 of development (switching on of the embryonic genome as precondition for further embryogenesis).
It is only by choosing the best blastocysts that one can make a statement as to whether 2-3 day embryos really have the potential for further development.
Blastocyst selection implies that the poorly performing ones are identified and are thus not used for transfer (natural selection)! With his help we were able to establish a new classification system in order to evaluate blastocysts after thawing.
Deciding on the best blastocysts to be transferred is a basic precondition for high success in Reproductive Medicine.
Let’s compare it to a football team: a local team, too, has players who can keep the ball in the air for several minutes (alternately with the foot and the head). In conventional IVF (in vitro fertilization) the zona pellucida (strong membrane that forms around an oocyte) functions as biological barrier against abnormal sperm, so that in most cases only “normal” sperm is able to fertilize an oocyte.In the previously described ICSI procedure this “natural” selection method is bypassed and instead the biologist decides on the best spermatozoa after morphological assessment (usually at a magnification of 200-400 x). Patients who are at high risk of Ovarian Hyperstimulation Syndrome or suffer from Polycystic Ovary Syndrome (PCOS).
Patients prior to chemotherapy when it is too late for ovarian stimulation and this procedure would only lead to further complications.
The examination of human embryos revealed that 80% of all embryos resulting from IVM presented chromosomal disorders. The spindle is an essential organelle of the egg and plays a central role in meiotic development of human eggs . In 15-20% of all cases the mature egg lacks the spindle before being fertilized by a sperm. Even in cases of repeatedly failed fertilization, spindle view represents an option (where appropriate, subject to be discussed with a doctor). Pre-Implantation-Diagnostics (PID) or Pre-Implantation-Genetic-Diagnosis (PGD) as it is known in Anglo-American countries has originally been developed as an alternative to prenatal diagnosis. The PGD is performed by examining a single cell with regard to aneuploidy (mal-distribution of chromosomes) and genetic diseases (overview, genetic diseases in detail, example: retinoblastoma). If, due to a malignant disease, a child’s bone marrow has to be destroyed by chemotherapy or radiotherapy, the sick child’s only chance of survival is either a matching bone marrow donation from a sibling or another suitable donor or the transplantation of stem cells from a cord blood donor to rebuild the hematopoietic system. Polar body testing allows conclusions to be drawn regarding the mother's genetic contribution (oocyte) to the embryo. This technique can be used to reduce the risk of miscarriage especially in patients of advanced maternal age and it may lead to slightly increased pregnancy rates. The biopsy is performed by removing a single cell or a maximum of two cells (blastomere) from the embryo -  usually on the 3rd day after fertilization at the 6 - 8 cell stage. This diagnostics is used mainly in cases of a specific genetic disorder running in a family and is specifically designed to diagnose whether an embryo is also carrier of the genetic condition of concern. In certain cases, this diagnostics can be suitable for investigating chromosomal disorders (aneuploidies) (e.g.
The analysis of cells removed from the blastocyst on day 5 of embryonic development (trophectoderm biopsy) is a technique that we are still in the process of further developing together with Alan Handyside (pioneer in PGD). For the future we hope that, due to this technique, we will be in a position to detect chromosomal disorders (aneuploidy) as well as genetic diseases (overview, genetic diseases in detail)  using a single diagnostic method (whereas to date, it is necessary to combine the methods of polar body diagnostics and blastomere biopsy on day 3 embryos). Analyzing blastocysts requires optimum freezing methods, since this procedure mostly exceeds the maximum period for which embryos can be kept in culture.
This method aims to make it easier for the developing embryo to hatch from the zona pellucida.
Performing this procedure is mainly useful in women with embryos having a very thick and tough zona pellucida (can easily be recognized using a polscope or an ordinary light microscope).
Depending on the specific medical findings this technique is not routinely applied in our IVF laboratories, but according to individual requirements. The hyaluronic acid binding test (PICSI) hyaluronan is used to select between immature and mature sperm cells. The zona pellucida (Zona pellucida,) is a glycoprotein membrane consisting of 3 layers surrounding an oocyte or embryo until the embryo performs zona-hatching on day 5 – 6 of embryogenesis at the blastocyst stage.


Using a polscope the zona pellucida can be assessed regarding the thickness of all three layers. The inner layer of the zona pellucida in particular seems to be an important non-invasive marker for the development potential of an oocyte.
Specific cryopreservation techniques that are exactly tailored to the cell-material to be frozen enable us to cryopreserve the following tissue material at our IVF Centers.
For tumor patients it makes sense to have their sperm cryopreserved prior to undergoing chemotherapy or radiation, thus being able to fall back on this stored material in case of a later infertility treatment. Investigations have shown that storage times of up to 30 years do not impair the sperm quality.
Owing to social circumstances, more women are planning to have their first baby later in life, i.e. For this reason and due to the negative "aging-effects" on the number and quality of oocytes it is getting more and more difficult to achieve pregnancy after the age of 38. Thus, you will have optimum chances to conceive a baby despite age related decline in female fertility. At our centers we offer this cryopreservation procedure at the highest possible technical and quality level.
Due to these cryopreservation procedures surplus embryos resulting from an IVF treatment can be preserved for a future pregnancy. If the impairment of ovary function is to be feared for patients suffering from malign illnesses, which may severely complicate or even prevent the occurrence of pregnancy, in addition to oocyte cryopreservation, ovarian tissue may be frozen. Women who may just not yet have found the right partner or women for whom it is not yet possible to have a child because of job-related reasons can have their oocytes or ovarian tissue frozen at an age of 25-35 years to cryopreserve them for future use in fertility treatment. There are two different injection techniques, the intramuscular and the subcutaneous injection. The increase in women having children later in life is causing many to ask, how old is too old to have a baby? May not be able to conceive or may take longer to conceive naturally; chances of getting pregnant in any given month at age 30 are about 20%, by 40 years old this chance drops to only 5%. May have to use expensive IVF treatments – keep in mind that fertility drugs carry their own risks and pregnancy is not guaranteed. If you understand and are willing to take the risks associated with having children later in life, then that is great. I know that a growing number of women are having children into their 40’s, but if I’m going to take the baby road I need to start packing. In both of the aforementioned cases the partygoer was obviously trying to make me feel better about being childless.
Pregnancy rates and the face of motherhood are changing as more and more women are waiting longer to have children.
Now this is starting to shift as the pregnancy rate for women in their 40’s is exploding and 40-something celebrities grace the pages of every gossip magazine. The CDC released a report in June 2012 revealing pregnancy rates broken down by different age groups and ethnicities. Pregnancy rates for women 20 to 24 years old also declined to the lowest level in more than three decades. The only age group to see an increase in pregnancies over the last twenty years is women in their 30s and early 40s, with the largest increase to women ages 40 to 44 years old. As the emerging face of motherhood, 40-somethings still face stigmas and an uphill battle for mainstream acceptance. Basic preconditions, however, are non-obstructed fallopian tubes in the woman and a normal semen analysis in the man (according to WHO criteria). In this case, stimulating hormones (gonadotropins, chlomifene) are being used to induce the ripening of 1 - 2 follicles in the ovary. Fertilization of the oocyte by only one single sperm typically occurs in the ampulla (upper part of the fallopian tube).
After a review of all existing test results and a thorough gynecological examination and assessment of semen analysis, a therapy schedule will be issued. After 16 to 18 hours of incubation there is a first microscopic evaluation that will reveal how many of the eggs have been fertilized (usually more than 70% of obtained eggs). The development of new media now enables us to keep the embryos in culture for a longer period of time and subsequently transfer one or two of them on day 5 (rarely on day 6) at the blastocyst stage.
Additionally, one or two more eggs may lead to pregnancy, however, eventually end in miscarriage. This is referred to as parthenogenesis (may also be triggered by an electric pulse or some other stimulus, e.g. The risk of miscarriage is about 5-10%, which corresponds to a baby-take-home-rate of 70-75%. The risk of having a multiple pregnancy amounts to at least 20-30% when two embryos are transferred to the uterus.
We have been actively involved in the development of this state-of-the-art technique that offers very high chances of embryo survival after thawing, in case further treatment will be necessary or if the couple is considering having a second child. Pierre Vanderzwalmen, who is a pioneer in the field of freezing embryos, sperm and oocytes as well as testicular and ovarian tissue.
Handling the ball like a professional (as coping with blastocyst culture) is a basic precondition to work one’s way up to the national team and perhaps taking part in world championships.
That also applies to patients having an extremely low sperm count.If no motile spermatozoa are present in the ejaculate, this method may help overcome infertility in men.
The method involves collecting oocytes from immature follicles that are subsequently left to mature in a culture medium. At our centers we perform this technique at the most advanced state of the art international standards. New ovarian stimulation techniques and specific therapeutic measures, however, reduce the risk and thus an IVM will seldom be required.
Furthermore, there might be negative effects on the growth processes of embryos and fetuses having developed from such eggs. The spindle is responsible for accurate alignment and distribution of the chromosomes during cell division. The presence of the spindle is – in addition to the first polar body – an indicator for maturation of the egg cell.


The absence of the spindle correlates with considerably reduced fertilization rates and poor or even no embryonic development.
Usually, the egg is positioned in such a way that the first polar body is at 12 o`clock and the injection of the sperm cell is performed at the 3 o` clock position.
Prenatal diagnosis is only possible when a pregnancy is already established, whereas PID can be performed on the embryo prior to the achievement of a pregnancy. This can either be done by using the Polymerase Chain Reaction (PCR) or the Fluorescence In Situ Hybridization (FISH) method. In this way it is possible to confirm or rule out the mal-distribution of chromosomes and the genetic predisposition towards certain diseases with a high degree of probability.
We are pleased to provide you with further details on this technique during a personal consultation. Only the embryos that are predicted to be free of the genetic condition are used for embryo-transfer. The assisted hatching procedure involves thinning or making a small hole in the zona pellucida. In particular with increasing age, the zona pellucida in some women becomes thicker and toughened. Such data allow a better determination of quality properties of the zona pellucida of oocytes and embryos. There is evidence that in patients above 35 years of age the inner layer of the zona pellucida is thicker and the zona pellucida’s glycoproteins seem to be less structured.
Six months after cryopreservation of the sperm, the donor is reinvestigated for the presence of specific infectious diseases in accordance with legal requirements. Therefore, we recommend you to have your oocytes cryopreserved at an early age (between 20 and 35 years of age) as a precaution. The conventional procedure of slow freezing as well as the vitrification procedure (ultra-rapid freezing in liquid nitrogen) is being successfully performed at our IVF Centers (the development rate of frozen and thawed embryos is high (90%)).
At 39 years old, the percentage of births when using the mother’s eggs was approximately 22%. Oz recommends moving “decisions about your fertility to the top of your priority list by the time you are at age 30.” This strategy avoids the most common pitfall associated with the increase in delaying motherhood, women not being aware of the risks (especially the risk that they may not be able to get pregnant). THE most important part of bringing a child into this world at any age is that the child is loved and wanted! When I said no she cheerfully exclaimed, “You still have time.” A martini later, I met an older gentleman who again asked about my procreation status. Realistically, I need 2 to 3 years to get ready and finish off my pre-baby bucket list of exotic travel and jumping out of airplanes. When I say that I don’t have children, people don’t ask “Do you want them?” or “Are you planning to have children?” I understand that having children seems to be the default life plan and that the majority of people want kids. New mothers in their late 30’s and early 40’s are becoming frequent at playgrounds and PTA meetings. What is apparent in this report is that birth rates have changed quite significantly in the last twenty years. This may be shocking to you with all of the “we’re all going to hell in a hand basket” talk and the media’s sensationalized coverage of the teen pregnancy epidemic. The three biggest factors experts credit with the decreased pregnancy rates for teenagers and women in their early 20’s is better education, more access to contraceptives, and later average age at first marriages. In some cases it proves to be favorable, if the couple undergoes psychological counseling prior to in vitro fertilization.
These chromosomal disorders may be identified by aid of the Pre-Implantation Genetic Diagnosis (examination of the egg’s polar body).
This relatively high rate is juxtaposed against an only insignificant beneficial effect on pregnancy rates (5-7%). Despite their liberal embryo protection laws, individual IVF clinics in countries such as Austria and the US (with a really broad range of treatment options available!) are nonetheless reporting suboptimal pregnancy rates! Only from the third day of embryonic development the genome in the sperm cell is switched on (late paternal effect). If the spindle isn’t optimally aligned (the spindle is normally close to the first polar body and thus quite in a distance from the site where the sperm is injected into the cytoplasm) it might be accidentally damaged when using a glass pipette for sperm injection, thus leading to the destruction of the egg . The same negative effects on the zona pellucida have been found in embryos after freezing and thawing. Under these conditions, the cells can be stored over a long period without impairment of their viability and function. Only if the results of the tests are negative the semen sample is released after this quarantine period of six months. With medical interventions continuing to push the motherhood age envelope, many are debating this very sensitive topic. Not to mention getting married and owning a house before bringing home baby…. The whole American Dream, minus the white picket fence. Fifty years ago, older mothers were considered quite odd and were harshly stigmatized by society. This age group has seen the most stability in reproductive patterns for many decades and remains the most popular time to enter into motherhood.
A recent study from the University College London’s Institute of Child Health showed children born to women over 40 years old benefited from improved language development and health until the age of five. Unfortunately, there is a negative correlation between increasing age and the frequency of chromosomal abnormalities, since the oocytes are aging. If you find yourself asking am I too old to have a baby look at the list of pros and cons below. Suboptimal culture conditions and less than optimum fertilization techniques might be the reasons why the egg stops developing on day 2-3.
My heart races, my chest tightens and I know what they really mean is, “you had better start doing something about it because you don’t have much time.”  Ugh!



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Comments to «Chances of getting pregnant after 40 years old 3.b?l?m»

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