A sod cutting ceremony with Finance Minister John Swinney has marked the building of a ?60 million research centre.
The Scottish Centre for Regenerative Medicine building will provide researchers with state-of-the-art laboratories to study diseases of the blood, bone, brain and liver. Its location next to the Royal Infirmary of Edinburgh will also help translate research from the laboratory bench into treatments for patients. The building, due for completion in 2010, will house the Medical Research Council Centre for Regenerative Medicine headed by Professor Sir Ian Wilmut. It will include researchers from a range of disciplines including those from the University’s internationally recognised Institute for Stem Cell Research.
The building forms a key part of the Edinburgh Bioquarter Development at Little France, a collaboration between the University, Scottish Enterprise and NHS Lothian.
Unless explicitly stated otherwise, all material is copyright © The University of Edinburgh 2016.
The upcoming lecture in our joint series with Edinburgh University Science Magazine (EUSci) will be given by Dr Tilo Kunath on Parkinson's disease and stem cells on 4th May 2015 at 7:30pm. Laboratory-grown replacement organs have moved a step closer with the completion of a new study. Scientists have grown a fully functional organ from transplanted laboratory-created cells in a living animal for the first time.
The researchers have created a thymus - an organ next to the heart that produces immune cells known as T cells that are vital for guarding against disease. They hope that, with further research, the discovery could lead to new treatments for people with a weakened immune system. The team from the MRC Centre for Regenerative Medicine at the University of Edinburgh took cells called fibroblasts from a mouse embryo.
The reprogrammed cells changed shape to look like thymus cells and were also capable of supporting development of T cells in the lab – a specialized function that only thymus cells can perform. When the researchers mixed reprogrammed cells with other key thymus cell types and transplanted them into a mouse, the cells formed a replacement organ. It is the first time that scientists have made an entire living organ from cells that were created outside of the body by reprogramming.


Doctors have already shown that patients with thymus disorders can be treated with infusions of extra immune cells or transplantation of a thymus organ soon after birth. With further refinement, the researchers hope that their lab-grown cells could form the basis of a thymus transplant treatment for people with a weakened immune system. The technique may also offer a way of making patient-matched T cells in the laboratory that could be used in cell therapies.
Such treatments could benefit bone marrow transplant patients, by helping speed up the rate at which they rebuild their immune system after transplant. The discovery offers hope to babies born with genetic conditions that prevent the thymus from developing properly.
We are pleased to announce the appointment of Dr Rickie Patani of Cambridge University as our first Rowling Fellow. Dr Patani is a post-doctoral Clinical Research Associate at Cambridge University (Anne McLaren Laboratory for Regenerative Medicine) and Specialist Registrar in Neurology at the National Hospital for Neurology and Neurosurgery, Queen Square. The Rowling Fellow designation is reserved for outstanding collaborators outside the University of Edinburgh whose research aims align closely with the goals of the Anne Rowling Clinic.
Association of fractional anisotropy (FA) with the DISC1 Ser704Cys allele in healthy individuals. This journal is a member of and subscribes to the principles of the Committee on Publication Ethics. Jaume Masia is Professor and Chief, Department of Plastic Surgery, Hospital de la Santa Creu I Sant Pau (Universitat Autonoma de Barcelona).
A patient’s own fat remains one of the most readily available substances for the rebuilding of breast form after cancer surgery or for aesthetic reasons. George Planas is head of Plastic, Reconstructive and Aesthetic Surgery at Clinica Planas in Barcelona and General Secretary and Founder Member Spanish Society of Antiaging and Longevity (SEMAL). Robert W Alexander is a private practice surgeon, editorial advisor to American Journal of Cosmetic Surgery and a board examiner for cosmetic surgery. Sebastian Gehmert, MD is currently doing research at University of Regensburg Dept of Plastic & Reconstructive Surgery specifically looking into lentiviral vectors as a tool to elucidate pathways in mesenchymal stem cells .
The British Science Association is a registered charity that exists to advance the public understanding, accessibility and accountability of the sciences and engineering in the UK.


They turned the fibroblasts into a completely different type of cell called thymus cells, using a technique called reprogramming. The problem is that both are limited by a lack of donors and problems matching tissue to the recipient. Older people could also be helped as the thymus is the first organ to deteriorate with age. His research focuses on motor neurone disease (MND), a rapidly progressive and invariably fatal neurodegenerative condition. Rowling fellowships are offered to promote collaborative research, innovation and partnership in the area of Regenerative Neurology.
Solving this large volume ‘fat barrier’ presents a multi dimensional regenerative medicine challenge including the growing of vascular structures that can provide a blood supply to keep the fat graft alive involving complicated inter-play of stem cells, growth factors and signalling molecules.
He is one of the founders of the “Tissue Engineering” competence centre in Lubeck, director of various German Federal Ministry of Education and Research (BMBF) projects focusing on tissue regeneration and is responsible for setting up a CTA team (composite tissue allotransplantation) to perform extremity transplants at TUM’s Klinikum rechts der Isar, Munich, Germany. Filip has been doing research in this field for many years including at the O'Brien Institute, Australia.
His post-doctoral research fellow in the Department of Molecular Pathology at MD Anderson Cancer Center Houston (USA), and participates in a number of international research collaborations. At present, the causes and underlying biology of this devastating disease are poorly understood. However in larger volumes these fat grafts remain unstable and have low survival rates 6 – 12 months post surgery losing from 50 – 60% of originally injected graft volume. The faculty all have world leading scientific and clinical experience in key factors contributing to this goal and the meeting is specifically set up to cross-pollinate ideas and give rise to research collaborations taking science from the laboratory into clinical practice.



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