The new University of Minnesota study set out to look at the decision-making processes that lead women to choose preventative mastectomy. Dr Kristi Funk was one of the main surgeon's who undertook Angelina Jolie's double mastectomy. Double mastectomies are a bigger operation associated with a longer recovery period and potentially more complications.
The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline. La sopravvivenza varia notevolmente a seconda della posizione del tumore, secondo un ampio studio epidemiologico francese. When you are told you have ovarian cancer and begin looking for treatment options, you may be concerned about life expectancy and quality of life.
How do you decide where to go for treatment after you have been diagnosed with ovarian cancer? The chart below shows the survival results of 25 advanced-stage ovarian cancer patients who were diagnosed between 2004 and 2008. Survival rates are also meaningful when compared to the results of other treatment centers.
As an alternative, we asked the independent biostatistician to analyze and compare our ovarian cancer rates to national cancer survival statistics that are gathered by the National Cancer Institute (NCI). The chart below shows a comparison between CTCA and SEER on the survival rates of advanced-stage, ovarian cancer patients who were diagnosed between 2000 and 2005. As you study the chart, it’s important to remember that the estimated CTCA survival rates were based on a relatively small sample of 28 advanced-stage ovarian cancer patients and therefore were subject to a high degree of variation.
The chart below shows the cancer survival rates for a group of 126 metastatic ovarian cancer patients who were diagnosed between 2000 and 2011.
Of the CTCA metastatic ovarian cancer patients shown in the above chart, the estimated survival rate at six months was 93%.
At Cancer Treatment Centers of America, we understand that you may also wish to see the survival rates of the group of metastatic ovarian cancer patients reported in the Surveillance, Epidemiology and End Results (SEER) database of the National Cancer Institute. Therefore, we asked an independent biostatistician to analyze both the survival rates of the group of CTCA patients and the group of patients included in the SEER database.
The objective of this analysis was to see how long each group of patients survived after their diagnosis.
We also want to be sure you understand that cancer is a complex disease and each person’s medical condition is different; therefore, CTCA makes no claims about the efficacy of specific treatments, the delivery of care, nor the meaning of the CTCA and SEER analyses.
This analysis included ovarian cancer patients from CTCA who were diagnosed from 2000 to 2011 (including 2000 and 2011) with a primary tumor site (as coded by ICD-O-2 (1973+)) of C569, and were considered analytic cases by the CTCA. Primary tumor sites (as coded by ICD-O-2 (1973+)), date of initial diagnosis, date of last contact, year of initial diagnosis, age of initial diagnosis, gender, vital status, and cancer histologic type as coded by the ICD-O-3. The database from the CTCA cohort was prepared by the CTCA cancer registrars from the following four hospitals: Southwestern Regional Medical Center hospital, Midwestern Regional Medical Center hospital, Eastern Regional Medical Center hospital, and Western Regional Medical Center hospital. The SEER program of the National Cancer Institute is an authoritative source of information on cancer incidence and survival in the United States.
This analysis included ovarian cancer patients from the latest SEER Limited-Use Database (as of 2014) who were diagnosed from 2000 to 2011 (including 2000 and 2011) with a primary tumor site (as coded by ICD-O-2 (1973+)) of C569.
Primary tumor sites (as coded by ICD-O-2 (1973+)), survival time recode as calculated by the date of initial diagnosis and the date of death or the follow-up cutoff date, year of initial diagnosis, age of initial diagnosis, gender, vital status, and cancer histologic type as coded by the ICD-O-3. In order to make a meaningful survival analysis, basic cancer and patient characteristics such as age at initial diagnosis, year of initial diagnosis, cancer stages, and cancer primary sites were first analyzed for both the CTCA and SEER samples.
For example, if a specific primary tumor site had patients in only one database, none of those patients were used in the analysis. The survival outcome from the CTCA database was defined as the time from the initial diagnosis to death and computed in number of years as the difference between the date of death and the date of initial diagnosis divided by 365.25.


For each survival outcome from each database, the survival curve, defined as the probability of cancer patient survival as a function of time after the initial diagnosis, was estimated by the nonparametric product-limit method[1]. Covariates such as age at initial diagnosis and year of initial diagnosis could affect the survival of ovarian cancer patients. We understand you may be feeling overwhelmed with questions and concerns about your type of cancer and what it all means. Explore our cancer hospitals, which house the latest treatments, technologies and integrative oncology services under one roof.
Discover our patient-centered approach, and how you get all your questions answered in a single visit by a dedicated team of cancer experts.
The research found women with early-stage breast cancer in one breast are increasingly opting to undergo a more aggressive operation to remove both breasts.This comes just a week after eminent British surgeon, Professor Kefah Mokbel of the London Breast Institute, warned that would be pointless for women who are not in the same category as Jolie. Le donne rispondono meglio degli uomini, ma e comunque migliorata nel corso degli ultimi quindici anni, per la maggior parte dei tumori, grazie ai progressi nel trattamento e alla diagnosi precoce.
At Cancer Treatment Centers of America® (CTCA), we believe you have the right to know our statistics for ovarian cancer treatment outcomes, so you can choose the best cancer care for you and your family. At Cancer Treatment Centers of America (CTCA), we believe that knowing the survival rates of ovarian cancer patients who are treated at our hospitals is one of the things that can help you and your family as you make this decision. This means that six months after their diagnosis, nearly 92 percent of the patients in this group were still alive.
Unfortunately, most hospitals and treatment centers don’t make their survival statistics available to the public.
This database is called the NCI Surveillance, Epidemiology and End Results Program, or SEER, for short. Because the SEER database did not provide staging information for patients diagnosed in 2004 and 2005, the SEER sample includes only those patients diagnosed between 2000 and 2003. Therefore, we asked an independent biostatistician to analyze the survival results of CTCA® patients. This means that six months after their diagnosis, 93% of the patients in this group were still living. SEER is a source of population-based information about cancer incidence and survival in the United States that includes the stage of cancer at the time of diagnosis and patient survival data. Our fifth hospital, located near Atlanta, Georgia, was not included because it was not open to patients until August 2012. The independent biostatistician computed the survival outcomes of metastatic ovarian cancer patients from the CTCA database and metastatic ovarian cancer patients from the SEER database who were diagnosed between 2000 and 2011. These factors significantly reduced the size of the CTCA sample, which means that the estimates reflected in the survival chart may be subject to high variation and may not be replicated in the future when we have a larger CTCA sample for analysis.
Not all cancer patients who are treated at a CTCA hospital may experience these same results. More specifically, the SEER Limited-Use Database contained a combination of three databases. The survival outcome from the SEER database was provided by the SEER Limited-Use Data File as the number of completed years and the number of completed months.
Formal statistical analyses of the ovarian cancer survival distributions between the CTCA database and the SEER database were conducted by the nonparametric logrank test and Wilcoxon test as well as the likelihood ratio test [1]. Similar estimates were also computed to estimate the difference of the survival rates at these time points between the two cohorts.
Therefore, additional adjusted analyses were completed on the survival outcomes between the CTCA and SEER samples after adjusting for the effects of these covariates. First, although a large cancer sample was available from the SEER program across many geographic regions in the United States, both samples, including the sample from CTCA, are convenience samples.
Lo studio evidenzia enormi variazioni a seconda della posizione del tumore: la sopravvivenza al tumore dei testicoli supera i 10 anni nel 93% dei casi, mentre per altri tipi di tumore non si arriva al 10%.


Therefore, we asked an independent, third-party biostatistician to analyze the ovarian cancer survival rates of patients who were treated at CTCA.
When they do, the results are not always consistently presented, so objective comparisons are difficult. This, among other factors, means that the estimates reflected in the survival chart may not be replicated in the future when a larger CTCA sample is available for comparison.
SEER collects information on cancer incidence, prevalence and survival from specific geographic areas that represent 28% of the population of the United States. In both cases, the patients had been diagnosed with distant (metastatic) cancer as discussed above. The SEER Program is a comprehensive source of population-based information in the United States that includes stage of cancer at the time of diagnosis and patient survival data.
Patients whose age at initial diagnosis fell into the overlap of the two ranges from the CTCA and SEER samples were included in the survival analysis.
These were then converted to the number of years by dividing the number of total months by 12. Because the estimated survival curves might not estimate the survival probability at these specific time points, survival rates from the closest observed survival times were used. The nature of these convenience samples prevents a causal interpretation of the statistical inferences. Lo studio copre tutti i nuovi casi di tumore diagnosticati tra il 1989 e il 2007 relativamente a 427.000 pazienti francesi. This means the cancer that had traveled from the primary site (ovary) to one or more distant sites in the body where it continued to grow. For these patients who were still alive or lost to follow-up at the time of entering the databases, their survival time was treated as statistically censored[1] at the difference between the date of last contact and the date of initial diagnosis. Because five-year survival rates have been popularly used in many cancer survival reports, five-year survival curves were also obtained by treating those who survived more than five years after the initial diagnosis as statistically censored at five years. Second, although some types of matching, as described above, were implemented to select the appropriate SEER and CTCA comparison samples, the distributions of important covariates such as age at initial diagnosis, race and year of initial diagnosis were not exactly the same between the CTCA sample and SEER sample.
Esso prevede, per 47 posizioni di tumori, la sopravvivenza per 1, 3, 5 e 10 anni dopo la diagnosi. Because patients surviving more than five years remained part of the risk sets in the estimation of survival rates at any time within five years of diagnosis, the truncated survival curves were identical to the first portion of the complete survival curves. Hence, even with the adjusted analyses, the possible confounding of these factors to the analyses and results cannot be ruled out. In particolare, la relazione indica un miglioramento della sopravvivenza a cinque anni per i tumori piu comuni (della prostata, del colon e della mammella). Another Cox proportional hazards model was also used to simultaneously adjust for the effects of both covariates (age at diagnosis and year of initial diagnosis) in the survival analysis.
In questi anni, comunque, la sopravvivenza per alcuni tipi di tumori associati all’alcool o al tabacco (tratto digestivo superiore e polmoni) non e migliorata. Third, the survival analyses were based on the statistical comparisons of the rate of death from all possible causes, not solely the cancer-specific death. Data from CTCA are not available for a statistical comparison on cancer cause-specific death rates.
I tumori con prognosi sfavorevole (sopravvivenza a 10 anni inferiore al 33%) riguardano il 40% degli uomini contro solo il 16% delle donne.



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