Risperidone is a second-generation antipsychotic that has affinity for D2, 5-HT2A, alpha 1, alpha 2 and H1 receptors. The mechanism of action of risperidone is not fully understood, current theories focus mainly on its ability to block D2 and 5-HT2A receptors.
It has been observed that from a pharmacodynamic perspective, all antipsychotics share a common feature: they reduce dopaminergic neurotransmission. According to the dopamine theory of schizophrenia, positive symptoms of schizophrenia might be explained through an overactivity of the mesolimbic pathway. Play the video below to learn more about the dopamine hypothesis of schizophrenia and the mechanism of action of antipsychotics.
The image below schematically illustrates the interaction of risperidone with different neurotransmitter receptors. Risperidone was synthesized based on attempts to replicate clozapine effectiveness without its side effects profile. However, when prescribed at higher doses, risperidone produces EPS consistently [4], indicating that 5-HT2A antagonism alone cannot eliminate EPS associated with substantial D2 receptor blockade.
The video mentions other theories of atypicality that are not applicable to risperidone such as fast dissociation from D2 receptors and 5-HT1A agonism.
The affinity of risperidone for D2 receptors is approximately 50- fold greater than that of clozapine and approximately 20-50 % that of haloperidol [7]. Risperidone is characterized by a very high affinity for 5-HT2A receptors, and a moderately high affinity for D2, H1, and alpha 1 and alpha 2 adrenergic receptors.
According to the dopamine theory of schizophrenia, the mechanism of action of risperidone might involve reduction of dopaminergic neurotransmission in the  mesolimbic pathway. Risperidone may be suitable to take during pregnancy, but safety has not been clearly established. Risperidone may be suitable to take if you are breastfeeding, although small amounts are excreted in breast milk and the effects on the infant are unknown. Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Search by medication name for information on over-the-counter or prescription medications including side effects and interactions. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgement of healthcare professionals. Search by medicine name or treatment for information including side effects and interactions.


Since risperidone has the potential to impair judgment, thinking, or motor skills, patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that risperidone therapy does not affect them adversely [see Warnings and Precautions (5.9)].
17.5 Concomitant Medication Patients should be advised to inform their physicians if they are taking, or plan to take, any prescription or over-the-counter drugs, since there is a potential for interactions [see Drug Interactions (7)].
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This site is provided for educational and informational purposes only, in accordance with our Terms of Use, and is not intended as a substitute for the advice of a medical doctor, nurse, nurse practitioner or other qualified health professional. More information about drug Risperidone Dispersible and also check out related information if you are using the pill has imprinted with P0.5 P1 P4 P2 P3 SZ Z1 SZ Z2 SZ Z4 SZ Z5 SZ Z7 or other codes. Like any other medication,Risperidone Dispersible also has side effects which are known to us or not be reported until now. This Peach Four-sided pill with imprinted P1 is Risperidone (dispersible) 1 mg from pill identification system,it is a(an) Prescription only medication and the strength of Risperidone (dispersible) 1 mg is 1 mg. This Peach Round pill with imprinted P4 is Risperidone (dispersible) 4 mg from pill identification system,it is a(an) Prescription only medication and the strength of Risperidone (dispersible) 4 mg is 4 mg. This Peach Four-sided pill with imprinted P2 is Risperidone (dispersible) 2 mg from pill identification system,it is a(an) Prescription only medication and the strength of Risperidone (dispersible) 2 mg is 2 mg.
This Peach Round pill with imprinted P3 is Risperidone (dispersible) 3 mg from pill identification system,it is a(an) Prescription only medication and the strength of Risperidone (dispersible) 3 mg is 3 mg.
The list of pills maybe not a whole list,share your knowledge about Risperidone Dispersible including side effects,interactions and etc,write it down and it will be appreciated very much. This white, oval pill imprinted with R 1 JANSSEN is a Risperidone 1 MG Oral Tablet [Risperdal], per the NIH. Negative and cognitive symptoms of schizophrenia have been linked to a dysfunction of the mesocortical pathway [1]. Positron emission tomography studies on D2 and 5-HT2 receptor binding in risperidone-treated schizophrenic patients. Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity.
Therefore it should not to be used unless clearly necessary and under careful supervision of your doctor. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule.


This copyrighted material is sourced from a licensed data provider and is not for distribution, except as may be authorised by the applicable terms of use. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse events, nor should it be construed to indicate that use of a particular medicine is safe, appropriate or effective for you or anyone else.
If you have serious side effects such as the following: fever, stiff muscles, confusion, sweating, fast or uneven heartbeats.
This means that high Ki numbers suggest low affinity at a given receptor, while low Ki numbers are associated with high affinity. A healthcare professional should be consulted before taking any medicine, changing any diet, or discontinuing any course of treatment. Use associated with disabling and potentially permanent side effects of the tendons, muscles, joints, nerves, and central nervous system that can occur together in the same patient. Shaking, muscle stiffness and feeding problems, all of which are reversible, have been seen in newborn babies when risperidone was used during the last trimester of pregnancy. Atypical antipsychotics may be better tolerated than other antipsychotics with fewer side effects of abnormal movements. Care must be taken to follow the instructions on how to take it in your patient information leaflet.
Therefore, before using risperidone, tell your doctor or pharmacist of all the products you use.
It is given by an injection into your muscle (intramuscular injection) every two weeks by a doctor or nurse. You should not drive or operate machinery until you have consulted your doctor or pharmacist for more details. It is important to continue taking this medication even if you feel well, unless your doctor tells you to stop. You must follow your doctor's instructions for stopping this medication as the dose may need to be lowered gradually over a few days.



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