Pulmonary fibrosis (PF) is a serious progressive lung disease and it originates from inflammation-induced parenchymal injury with excessive extracellular matrix deposition to result in the destruction of the normal lung architecture. Effect of mKG on the mRNA Expression of IL-6 in the lung tissues of BLM-induced pulmonary fibrosis mice. Effect of mKG on the mRNA Expression of IL-17 in the lung tissues of BLM-induced pulmonary fibrosis mice. Effect of mKG on the mRNA Expression of Col-1, Col-3 in the lung tissues of BLM-induced pulmonary fibrosis mice by immunohistochemical analysis.
Effect of mKG on the content of TGF-?1, HYP, IL-6 and IL-17 in the lung tissues of BLM-induced pulmonary fibrosis mice by ELISA analysis. Effect of mKG on the expression of ?-SMA in the lung tissues of BLM-induced pulmonary fibrosis mice by Western blot analysis. In order to feel well, you need to treat the fundamental cause of illness, not mask symptoms. Although all hospitals around the world may appear to heal diseases extremely well, often in the process, treatments destroy the immune system and aggressive treatments kill normal healthy cells. Many people nowadays blindly believe in synthetic drugs, but their harmful consequences are truly severe and enormous. The real problem with synthetic medicine is that its nature is foreign to the body, and it is simply not possible to expect the body to find homeostasis and true health as a result of injecting it with a foreign substance. On the other hand, your body has been designed to recognize and be friendly toward the countless substances in nature. Many drugs, including steroids, antihistamines, antibiotics, anti-inflammatories, and anti-cancer drugs, are toxic to the body and accumulate in it. For these reasons, it is not right to try to treat a disease without addressing the fundamental cause. Anyone who gets sick will resort to medicine with two desires: first that the drug be effective and secondly that it work quickly. For example, hypotensive drugs for high blood pressure, and drugs for diabetes and asthma are highly effective. However, once you start these drugs, there is no natural stopping point, and you may have to take them for the rest of your life. Then before you know it, you will be taking a fistful of drugs, and your body will become increasingly more tired, with soreness, numbness, and pain in the limbs. Once the tonsils are strengthened, you will then be able to heal from a wide range of diseases.
The improved health of the lungs will also improve the elimination of waste via the skin and can thus heal atopic conditions such as eczema.
I have attempted to present an alternative means of true healing, one that does not require any synthetic drugs and works by restoring the immunity and natural healing capabilities of body.
A large number of medical doctors, professors, and patients with chronic diseases throughout the world who have read these columns and emailed me messages of encouragement and a wide range of inquiries have further motivated me in my writing. Following delivery, approximately 13% of new mothers experience a major depressive episode (Wisner et al., 2002). Omega-3 polyunsaturated fatty acids offer significant health benefits to pregnant and nursing women and their infants. Modified Kushen Gancao Formula (mKG), derived from traditional Chinese herbal medicine, has a prominent anti-inflammatory effect. IntroductionPulmonary fibrosis (PF) is a serious chronic lung disease with unknown pathogenesis. Results of Immunohistochemistry Staining for Col-1 and Col-3In Figure 5, the expression of Col-1 and Col-3 was markedly increased in the BLM group when compared with the normal group, and the expression of Col-1 and Col-3 could be inhibited in groups that were treated with mKG, pirfenidone and dexamethasone by immunohistochemistry testing. Changes in Protein Expression of a-SMAThe expression of ?-SMA was tested by Western blot analysis (Figure 7). DiscussionPF is a chronic lung disease characterized by excessive accumulation of extracellular matrix (ECM) deposition to mesenchymal transition (EMT), which finally leads to the decline of lung function.
However, once patients start to take them, they usually become slaves to these drugs, needing more and more to suppress symptoms in a constant cycle of repression and recurrence that aggravates their bodies. This causes patients to die gradually, suffering from pain induced by the toxicity of the drugs.
This is because when a foreign substance enters, your body will become highly tense, and the next time it encounters this unfamiliar substance, it will reject it. So when it encounters natural medicines, your body will welcome them as though meeting a long-cherished friend. The accumulation of toxic waste in the body accordingly ends up destroying the immune systems of patients, which leads to the severe aggravation of chronic diseases. These kinds of drugs should be reserved for temporary use during emergency situations but not continued over long periods of time to maintain health. Patients will experience an immediate drop in blood pressure or blood glucose levels, or the quick cessation of asthma symptoms. With this constant pain, the will and desire to live will gradually and increasingly drain out of you. After two months of cleansing your lungs with herbal therapy, you will not catch the common cold anymore, chronic nasal inflammation (rhinitis) will disappear after three months, and the roots of asthma will be uprooted after four months of cleansing the lungs. Although antibiotics and anti-inflammatory medications are effective at killing viruses, you can also overcome them if you have fortified the health of the tonsils. I would like to convey my sincerest gratitude for the interest and support of all readers and sincerely hope that you will be able to join me in the new era of strong immunity through cleansing the lungs with herbal medicine.


Seo Hyo-seok is the director of the Pyunkang Korean Medicine Hospital, which has seven branches in South Korea, one at Stanton University in California, and one in Atlanta. Nevertheless, many new mothers are reluctant to take medications while nursing because they are concerned about the potential adverse effects on their infant. However, few studies have examined these alternative treatments for depression occurring in the postpartum period. The present study is to explore the inhibitory effects of mKG on bleomycin (BLM)-induced pulmonary fibrosis in mice.
It is a progressive and lethal lung disease, characterized by the accumulation of extracellular matrix in the alveolar septum to result in the destruction of the normal lung architecture [1,2].
All sections were stained with HE and representative sections are shown at the same magnification (200?). All sections were stained with Masson trichrome and representative sections are shown at the same magnification (200?). Especially in the mKG-H group and positive control (pirfenidone and dexamethasone) groups, Col-1- and Col-3-stained area fractions were about half of that in the BLM group or even less. IL-6 and IL-17 concentrations in the BLM group were obviously increased compared with the normal group, whereas the administration of mKG significantly reduced these two cytokines levels in the lung tissues (Figure 6).
Historically, pulmonary fibrosis was believed to result mainly from chronic inflammation [25]. This is the reason why our body, which is born out of the nature, responds well to herbal medicine. You do not have to take any synthetic drugs to heal chronic diseases, and you can feel extremely comfortable and be healthy.
This will naturally lead to the optimal conditions for the health of the tonsils, which are a key first line of defense of the immune system. With healthy tonsils, you will have little difficulty overcoming infectious diseases such as MERS, SARS, avian flu, and swine flu. With this therapy, thousands of people have been able to enjoy a long life in great health. Further, antidepressants are not universally effective and often produce unacceptable side effects such as reduced libido. Underscoring the importance of maternal dietary supplementation of omega-3 fatty acids, the high fetal demand for these fatty acids can lead to a 50% reduction of the maternal levels (Hornstra, 2000). If the preliminary data on omega-3 fatty acids' positive mood effects are corroborated in larger studies, they will become a safe and healthful treatment option for depression occurring during pregnancy and the postpartum period. The current treatment for PF includes corticosteroids and immunosuppressive agents, but the outcomes of therapy are not satisfying. In the group treated with mKG, the expression of ?-SMA was much lower than in the BLM group, especially in the high-dose group.
The persistent immune response to injury led to inflammation, tissue remodeling and repair processes taking place constantly. It is a very dangerous thing for doctors to treat diseases without treating their underlying causes.
Seo entered Kyung Hee University in Korea at the top of his class and after years of research, developed the Pyunkang-Hwan herbal formula, which improves immunity by strengthening lung function. It has helped cure over 155,000 patients of various conditions. Women with a previous history of depression are at a particularly high risk for depression (Wisner et al., 2002). Many women look forward to a renewed intimacy with their partners after the pregnancy and prefer not to take medications with such a side effect. Research has demonstrated that the risk of preterm labor is reducedin women who consume omega-3 fatty acids during pregnancy (Olsen and Secher, 2002).
It markedly alleviated the increase of HYP content in the lung tissues and pathologic changes of pulmonary fibrosis caused by BLM instillation. Traditional Chinese medicines (TCMs) are gaining more attention all over the world due to their holistic concept of TCM theory and long historical clinical practice. Because environmental pollution is more and more serious, the incidence of PF has been on the rise in China recently, and it is a progressive and fatal pulmonary disease without proven drug therapies. Additional risk factors include conflict with the baby's father, stressful life events and child care stresses.
In conclusion, mKG has an anti-fibrotic effect and might be employed as a therapeutic candidate agent for attenuating pulmonary fibrosis. Although the mechanisms of PF are not understood fully, transforming growth factor-?1 (TGF-?1) is recognized as a critical factor in inducing fibrosis [26,27,28]. Furthermore, studies have also confirmed that inflammation factors such as IL-6 and IL-17 contribute to the process of PF [29,30].The pulmonary fibrosis model induced by BLM is widely used to study the anti-fibrotic effects of numerous drugs.
Attending weekly therapy sessions, however, is frequently difficult for women who are looking after one or more small children at home.
BLM causes alveolar cell damage, inflammatory response, fibroblast proliferation and subsequent collagen content deposition [31,32]. Kushen Gancao Tang has been recorded in Zhong Miao Xian Fang, a classic medical book published in the Ming dynasty of China. It is important to keep in mind, however, that the purity and potency of commercially available preparations of St. It is comprised of two medicinal herbs, Kushen and Gancao, which have been used to treat choleplania, infection, esoenteritis and dysentery for a long time. In our in vivo study, the body weight of rats decreased, the hydroxyproline content of the lungs increased, and pathologic changes of pulmonary fibrosis markedly appeared after BLM instillation.


Now Kushen Gaocao Formula has been used in the clinic to treat hepatitis and immune system diseases [3]. According to the results of the histological analysis, we can prove the inhibition effect of mKG on inflammation and pulmonary fibrosis. Food and Drug Administration minimally regulates most herbal products sold in the United States. Kushen has been used in China for its cleaning heat, drying humidity and diuresis for a long time. Pharmacological studies have shown its anti-angiogenic, anti-inflammatory and anti-nociceptive activities. Many studies have created a strong rationale for an antifibrotic strategy in which the principal objective of treatment is blocking TGF-?1. So Kushen has been widely used for treating various inflammatory and infectious diseases in the clinic, such as eczema and upper respiratory tract infections.
The inhibition effect of mKG on TGF-?1 could be shown from the results of the ELISA analysis and the expression of ?-SMA was downregulated according to the results of the Western blot. It has also been used for treating asthma by suppressing airway responses, decreasing inflammation and down-regulating Th2 levels in asthmatic-model mice [5]. Our previous studies suggested that mKG attenuated BLM-induced PF in rats via the inhibition of ECM. Gancao has been used as an herbal medicine for centuries in China to treat various diseases such as gastric or duodenal ulcers, hepatitis, sore throats, coughs, bronchitis, arthritis, allergies, and cardiovascular disease [8,9]. A main pathological cause of PF is the imbalance between the synthesis and degradation of ECM which increases the production of type I and type III collagen (Col-1, Col-3) [35]. Gancao and its active compounds including glycyrrhizin, isoliquiritigenin and ?-glycyhrritinic acid have been shown to possess prominent anti-inflammatory activities and can inhibit reactive oxygen species (ROS) [10,11,12]. Compared with the model group, mKG significantly reduced the content of HYP, Col-1 and Col-3, especially for the high-dose group. Glycyrrhizic acid can alleviate carbon tetrachloride-induced liver fibrosis and bleomycin-induced pulmonary fibrosis in rats [13,14]. Modern research showed that Dang-Gui has broad pharmacological effects on cardiovascular diseases, gynecological diseases and immune system disorders [15,16]. Myofibroblasts are highly synthetic for collagen, featured by the presence of ?-SMAs, which are the primary effector cells during the progression of fibrosis [36,37]. The combination of Dang-Gui and Kushen is extensively used in traditional Chinese medicine to treat inflammatory diseases, such as acne, heart disease, and hepatitis [17].Considering the properties of those herbs, the Kushen Gancao Tang has been modified in expectation of the synergistic enhancement of its anti-inflammatory and anti-fibrotic effects. The downregulation of the expression of ?-SMA also confirmed the fact that mKG could inhibit the production of ECM. In addition, Modified Kushen Gancao Formula has been used to treat bronchial asthma and chronic obstructive pulmonary disease (COPD) in Pingjin Hospital, Tianjin, China, whereas there are no reports about the effects of Modified Kushen Gancao Formula on PF. Additionally, the mechanisms by which Modified Kushen Gancao Formula suppresses inflammatory and fibrotic effects have not been fully elucidated.Although the mechanisms of PF are not understood fully, transforming growth factor-? (TGF-?) is recognized as a critical factor for inducing fibrosis. In the early period of PF, inflammatory factors such as interleukin-17 (IL-17) and interleukin-6 (IL-6) play an important role in autoimmunity.
IL-17 is a novel family cytokine that consists of six protein members (from IL-17A to IL-17F), which play an important role in many chronic inflammatory diseases [18,19,20,21].
Bleomycin (BLM), an antineoplastic drug, has been reported to cause fibrosis in different species of animals [22,23,24]. The intratracheal instillation of BLM was widely accepted as the method to develop the model of lung fibrosis.
Here we focused on exploring whether the mKG decreases the expression of TGF-? and inflammatory factors so that it can attenuate BLM-induced PF.
The mice were kept in community cages with 12 h periods of light and dark cycles and maintained on standard rodent chow with access to water ad libitum. All animal care and experimentation was approved by the principles and guidelines of the National Institutes of Health Guide for the Care and Use of Laboratory Animals. On the 21st day, the blood of the mice was drawn from the abdominal aorta under pentobarbital anesthesia and the lungs were removed. The left lungs were used for histological examination, and the right lungs were frozen in liquid nitrogen.
Measurement of Content of Hydroxyproline,TGF-?1, IL-6 and IL-17 in Lung TissuesHydroxyproline (HYP) content of lung tissue was measured by using hydroxyproline kits (Nanjing Jiancheng Biochemical Institute, Nanjing, China). TGF-?1 in lung tissue was tested by ELISA kit (Nanjing Jiancheng Biochemical Institute, Nanjing, China). IL-6 and IL-17 were tested by ELISA kit (Nanjing Jiancheng Biochemical Institute, Nanjing, China).
Two micrograms of total RNA from each sample were reverse-transcribed to cDNA which was used for PCR. Comparison between groups was performed with test of homogeneity of variances and one-way analysis of variance (ANOVA), and post hoc analysis was performed using Bonferroni or Dunnett’s multiple comparison tests.



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