Gestational trophoblastic disease (GTD) is a group of rare diseases in which abnormal trophoblast cells grow inside the uterus after conception.
In gestational trophoblastic disease (GTD), a tumor develops inside the uterus from tissue that forms after conception (the joining of sperm and egg). Most GTD is benign (not cancer) and does not spread, but some types become malignant (cancer) and spread to nearby tissues or distant parts of the body. A complete HM forms when sperm fertilizes an egg that does not contain the mother’s DNA. A partial HM forms when sperm fertilizes a normal egg and there are two sets of DNA from the father in the fertilized egg. A very high level of beta human chorionic gonadotropin (I?-hCG), a hormone made by the body during pregnancy. Gestational trophoblastic neoplasia (GTN) is a type of gestational trophoblastic disease (GTD) that is almost always malignant. Invasive moles are made up of trophoblast cells that grow into the muscle layer of the uterus. A choriocarcinoma is a malignant tumor that forms from trophoblast cells and spreads to the muscle layer of the uterus and nearby blood vessels. Tubal pregnancy (the fertilized egg implants in the fallopian tube rather than the uterus). A placental-site trophoblastic tumor (PSTT) is a rare type of gestational trophoblastic neoplasia that forms where the placenta attaches to the uterus. An epithelioid trophoblastic tumor (ETT) is a very rare type of gestational trophoblastic neoplasia that may be benign or malignant.
These and other signs and symptoms may be caused by gestational trophoblastic disease or by other conditions.
Fatigue, shortness of breath, dizziness, and a fast or irregular heartbeat caused by anemia. Treatment options also depend on whether the woman wishes to become pregnant in the future. After gestational trophoblastic neoplasia has been diagnosed, tests are done to find out if cancer has spread from where it started to other parts of the body. The process used to find out the extent or spread of cancer is called staging, The information gathered from the staging process helps determine the stage of disease. CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, taken from different angles.
Hydatidiform moles (HM) are found in the uterus only and do not spread to other parts of the body. The treatment of gestational trophoblastic neoplasia is based on the type of disease, stage, or risk group. Placental-site trophoblastic tumor (PSTT) and epithelioid trophoblastic tumor (ETT) treatments depend on the stage of disease.
Recurrent gestational trophoblastic neoplasia (GTN) is cancer that has recurred (come back) after it has been treated. Gestational trophoblastic neoplasia that does not respond to treatment is called resistant GTN.
There are different types of treatment for patients with gestational trophoblastic disease. Different types of treatment are available for patients with gestational trophoblastic disease. Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
Even if the doctor removes all the cancer that can be seen at the time of the surgery, some patients may be given chemotherapy after surgery to kill any tumor cells that are left.
Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. Patients who take part in clinical trials also help improve the way cancer will be treated in the future. Some of the tests that were done to diagnose the cancer or to find out the stage of the cancer may be repeated. Blood levels of beta human chorionic gonadotropin (I?-hCG) will be checked for up to 6 months after treatment has ended. After surgery, beta human chorionic gonadotropin (I?-hCG) blood tests are done every week until the I?-hCG level returns to normal.
If the level of I?-hCG in the blood does not return to normal or the tumor spreads to distant parts of the body, chemotherapy regimens used for high-risk metastatic GTN are given. Intrathecal chemotherapy and radiation therapy to the brain (for cancer that has spread to the lung, to keep it from spreading to the brain). Chemotherapy with one or more anticancer drugs for tumors previously treated with surgery. Physician Data Query (PDQ) is the National Cancer Institute's (NCI's) comprehensive cancer information database.
This PDQ cancer information summary has current information about the treatment of gestational trophoblastic disease.
The information in this patient summary was taken from the health professional version, which is reviewed regularly and updated as needed, by the PDQ Adult Treatment Editorial Board. A clinical trial is a study to answer a scientific question, such as whether one treatment is better than another.
The information in these summaries should not be used to make decisions about insurance reimbursement.
More information about contacting us or receiving help with the Cancer.gov Web site can be found on our Contact Us for Help page. The NCI's LiveHelp® online chat service provides Internet users with the ability to chat online with an Information Specialist.
The NCI Web site provides online access to information on cancer, clinical trials, and other Web sites and organizations that offer support and resources for cancer patients and their families. There are also many other places to get materials and information about cancer treatment and services. The NCI has booklets and other materials for patients, health professionals, and the public.
As we continue our trigger point journey down the back, I thought it pertinent to talk about the mid back.
I have seen a few clients leave with so much relief for their back that they didn’t need their original scheduled surgery!
These abdominal points are not as common as trigger points in the QL (quadratus lumborum) or back muscles. If you are having pain patterns like the picture to the right, a massage for your abs, is probably the best thing you can do to relieve the pain. When this point becomes chronic or over-activated, you will also feel achiness or pain down the back of the arm, as the red stippling in the pic shows.
As always, if you can’t figure out how to relieve your aches and pains, please see a professional.
Before I dive straight into specific areas of pain that we can address (and you can address at home), I thought it important to talk about trigger points in general- what exactly are they anyway? Trigger points are found in soft tissues, primarily muscles and fascia (the connective that acts like a web throughout your body to hold everything together). A trigger point is a small area of muscle that has stayed contracted without a nerve impulse, forming a little knot. Trigger points are best treated by massage – self massage can do the trick too!- but more specifically, Trigger Point Therapy, where the massage therapist places pressure on the trigger point, usually causing some tenderness and referral sensations. If you are afraid of starting to exercise (or getting back into exercise) because of pain, start by talking to some specialists and ask their opinion- maybe a physical therapist, a crossfit trainer, an acupuncturist, or a massage therapist (not a surgeon!). Do you have a specific area of pain you’d like me to talk about in my next article on trigger points?
As a massage therapist in Salt Lake City, I have seen runners, bikers, hikers, crossfit goers, and the average Joe come in with knee pain.
Most of these clients have been told to take advil, rest, and if it doesn’t get better, they should talk to a surgeon. You’d lay on the ground, knees up and place the small ball just below the top of one hip.


After the most intense massage of my life, everything works better and my performance has improved. Massage Therapy Salt Lake: Integrating Trigger Point Therapy, Deep Tissue, and Structural Integration techniques.
Now, I’d be more likely to say “massage” or “balance” or “personal improvement.” Today’s hot tub is about complete rejuvenation. But in a Caldera hot tub, each station is a relaxing seat with jets aligned to focus on massaging those same muscle groups.
From there, selected models have independently controlled jets above the water level that massage downward on tired neck muscles. Continuing to focus on the back, a high-volume jet at the next station delivers a swirling effect. Then on to one of the other areas where the jets focus on the long muscles on the back of the thigh. I like that there are no mandatory movements here, and no special order that you need to follow.
Trophoblast cells help connect the fertilized egg to the wall of the uterus and form part of the placenta (the organ that passes nutrients from the mother to the fetus). The egg has DNA from the father and the cells that were meant to become the placenta are abnormal. Only part of the fetus forms and the cells that were meant to become the placenta are abnormal.
It may also spread to other parts of the body, such as the brain, lungs, liver, kidney, spleen, intestines, pelvis, or vagina. The tumor forms from trophoblast cells and spreads into the muscle of the uterus and into blood vessels. Having a risk factor does not mean that you will get cancer; not having risk factors doesn't mean that you will not get cancer.
A history of the patient’s health habits and past illnesses and treatments will also be taken. A doctor or nurse inserts one or two lubricated, gloved fingers of one hand into the vagina and presses on the lower abdomen with the other hand. Certain substances are linked to specific types of cancer when found in increased levels in the body. An x-ray is a type of energy beam that can go through the body onto film, making pictures of areas inside the body.
This is done by placing a needle between two bones in the spine and into the spinal column. Cancer cells break away from where they began (the primary tumor) and travel through the lymph system or blood. The cancer gets into the lymph system, travels through the lymph vessels, and forms a tumor (metastatic tumor) in another part of the body.
The cancer gets into the blood, travels through the blood vessels, and forms a tumor (metastatic tumor) in another part of the body. For example, if choriocarcinoma spreads to the lung, the cancer cells in the lung are actually choriocarcinoma cells. The stage of the invasive mole or choriocarcinoma is one factor used to determine risk group.
Patients with low-risk disease usually receive less aggressive treatment than patients with high-risk disease.
Some treatments are standard (the currently used treatment), and some are being tested in clinical trials.
The cervix is dilated and the material inside the uterus is removed with a small vacuum-like device. A speculum is inserted into the vagina to widen it in order to look at the cervix (first panel).
If the uterus and cervix are taken out through the vagina, the operation is called a vaginal hysterectomy. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). Treatment given after the surgery, to lower the risk that the cancer will come back, is called adjuvant therapy. Patients who take part in a clinical trial may receive the standard treatment or be among the first to receive a new treatment. Even when clinical trials do not lead to effective new treatments, they often answer important questions and help move research forward. See the Treatment Options section that follows for links to current treatment clinical trials. The results of these tests can show if your condition has changed or if the cancer has recurred (come back). This is because a I?-hCG level that is higher than normal may mean that the tumor has not responded to treatment or it has become cancer.
Treatment is given until the beta human chorionic gonadotropin (I?-hCG) level is normal for at least 3 weeks after treatment ends. The PDQ database contains summaries of the latest published information on cancer prevention, detection, genetics, treatment, supportive care, and complementary and alternative medicine.
These Boards are made up of experts in cancer treatment and other specialties related to cancer.
If you want to use an image from a PDQ summary and you are not using the whole summary, you must get permission from the owner. More information on insurance coverage is available on Cancer.gov on the Managing Cancer Care page. Besides trigger points (TrPs) along the spine referring localized pain, there are a couple of overlooked TrPs in neighboring muscles that refer pain to the mid back (thoracic region). Doctors will most often tell you to take pain meds, and sometimes they’ll have you see a physical therapist or chiropractor, but around 85% of pain is from soft tissue issues. The following articles will be specific to areas like the shoulder, low back, neck, etc, so stay tuned! They are primarily caused by muscle overload (whether it be from postural overload, repetitive stress overload, exertion overload, etc). This usually causes a muscle to feel tight, and it will contribute to weakening the rest of the muscle. Janet Travell, who pioneered myofascial pain research and treatment, trigger points are the sole cause of pain seen in clinics 85% of the time.
This pressure helps release the held muscle tissue, and causes more blood flow (and thus oxygen for healing) to the area.
They will give you a good idea as to what you might be able to do and whether or not you might need to see a surgeon or might not.
This should be done by stacking your spine, not by forcing your shoulders back and your chest forward.
While some might need surgery because of major ligament and meniscus tears, the average person has knee pain from trigger points in the muscle or fascia. Pain on the Outside of the Patella (knee cap) is often attributed to Vastus Lateralis trigger points. Inner Knee Pain is usually caused by a tight IT Band, running along the outside of your thigh and attaching into 2 important muscles at the hip- Gluteus Maximus & TFL.
You then roll on your side on the ball, and play around with moving the ball until you find  a tender spot (a trigger point) and hold there for a minute. Myofascial massage and trigger point therapy techniques are extremely helpful for relieving postural imbalances, so pain doesn’t reoccur, and the original movement pattern can be corrected. Do something about it, have hope, and try a few of these tips to get you on your way to healthy knees!
As an athlete, I’m less interested in pampering and really just want my body to function properly after things go wrong. In about 20 minutes every day, you can get a restorative massage that relaxes, works knots out of tense muscles while increasing circulation and reducing aches and pains. It’s an innovative design idea called Hot Tub Circuit Therapy and it’s patterned after circuit weight training where you move from station to station, performing different exercises that help you work all your major muscle groups.
You can adjust the intensity of that massage at any station from a gentle sensation to a deep, penetrating massage.


Two rows of jets work on the back muscles on both sides of your spine, focusing on the latissimus dorsi, the rhomboid muscles and the trapezius. A pair of larger jets focuses on the low part of your back where tension tends to accumulate and where many lower back problems develop. Until there are signs or symptoms of the tumor, the pregnancy will seem like a normal pregnancy. For TVUS, an ultrasound transducer (probe) is inserted into the vagina to make the sonogram. A sample of CSF is removed and checked under a microscope for signs that the cancer has spread to the brain and spinal cord. Before starting treatment, patients may want to think about taking part in a clinical trial. The walls of the uterus are then gently scraped with a curette (spoon-shaped instrument) to remove any material that may remain in the uterus. If the uterus and cervix are taken out through a large incision (cut) in the abdomen, the operation is called a total abdominal hysterectomy.
Clinical trials are done to find out if new cancer treatments are safe and effective or better than the standard treatment. There are also clinical trials that test new ways to stop cancer from recurring (coming back) or reduce the side effects of cancer treatment. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests. If the level of I?-hCG does not return to normal or increases, it may mean the hydatidiform mole was not completely removed and it has become cancer. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Each trial answers certain scientific questions in order to find new and better ways to help cancer patients. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. Besides lengthening the front of the spine, treating TrPs in the rectus abdominis, aka your abs, can provide great relief for mid and low back pain.
If you’ll notice in the picture, there is also a low trigger point that refers pain to the low back. Generally, lengthening the front of your body can help with a host of issues, including back and neck pain.
Sometimes this muscle gets strained during pullups, so if you’ve got this pain pattern showing up after a good pullup workout, chances are you just aggravated your lats. This is a great technique if you just want to improve your overhead reach because chances are, you have short lats.
And a skilled massage therapist, who works with soft tissue and clients in pain, should be one of the first people you see. And trigger points cause localized pain or referred pain to another area, which is how some trigger points are left untreated- we assume the area of pain is the place to treat. A trigger point, if left untreated, causes a chain reaction of other trigger point areas emerging, as other muscle groups have to compensate for this weakened, inefficient muscle. Creating some minor, bearable pain while pressing on a trigger point will send your brain a signal- there is pain!
Building up strength with prevent muscle overload (remember, that’s the primary cause of trigger points). Here’s a great video by Ruthie Streiter (a dear friend of mine in NY) that I recommend many of my clients to watch so they can sit well.
It is not just the resolution of pain or disease that is important, but also the knowledge and understanding we receive along the way. Tears in the ligaments can also be caused by movement imbalances; lengthening of short, tight fascia will help address these imbalances, even after surgery. The IT Band is hard to change without relieving the tightness in the TFL, Glut Max, and surrounding fascia. Sometimes all it takes is 1 or 2 specialized massage therapy sessions (including some personalized self care) to get you back up and running! A PSTT grows very slowly and signs or symptoms may appear months or years after a normal pregnancy. For GTD, the blood is checked for the level of beta human chorionic gonadotropin (I?-hCG), a hormone that is made by the body during pregnancy.
A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. A curette is put through the cervix into the uterus to scrape out abnormal tissue (last panel).
If the uterus and cervix are taken out through a small incision (cut) in the abdomen using a laparoscope, the operation is called a total laparoscopic hysterectomy. In a total hysterectomy with salpingo-oophorectomy, (a) the uterus plus one (unilateral) ovary and fallopian tube are removed; or (b) the uterus plus both (bilateral) ovaries and fallopian tubes are removed.
Pregnancy causes I?-hCG levels to increase, so your doctor will ask you not to become pregnant until follow-up is finished.
During treatment clinical trials, information is collected about the effects of a new treatment and how well it works. Information about using the images in this summary, along with many other images related to cancer can be found in Visuals Online. Then, a slight neurological happening occurs- when the massage therapist (or you) releases pressure on the point, the pain goes away and your brain forgets about the previous, chronic pain that was there to begin with. I highly recommend crossfit because of it’s varied exercises and importance in taking the joints to their full range of motion (just make sure you go at your own pace). If this is hard for you, you can also try sitting at the back of your seat, using the seat’s back to prop your butt so it has that slight curve. Lengthening the TFL might require some assistance, and is difficult to attempt on your own, but using a racquet, tennis, or lacrosse ball on the top of your hip in the area of Gluteus Medius could do the trick.
Instead of a general rubdown that fixes nothing, Leah focused on the parts that were broken and went to work.
When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.
In a radical hysterectomy, the uterus, cervix, both ovaries, both fallopian tubes, and nearby tissue are removed. Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer. If a clinical trial shows that a new treatment is better than one currently being used, the new treatment may become "standard." Patients may want to think about taking part in a clinical trial. Information Specialists can help Internet users find information on NCI Web sites and answer questions about cancer. You might need some guidance to get to the root of the problem (I know I have a hard time figuring out what’s actually going on with me without an outside eye), so seek help. If you are just running or just biking or just getting on the eliptical, you are not moving your body at full capacity. For this kind of knee pain, lay on the side of your thigh on the foam roller and roll from your hip to your knee. But no matter how you do it, you’ll leave your hot tub feeling FAR better than when you started.
Both versions have cancer information that is accurate and up to date and most versions are also available in Spanish. We at Free Bodied are always here to answer any questions you might have to help lead you towards pain relief. We all start somewhere, so if it’s starting with a 10 min walk 4 times a week, start there!
The doctor or nurse also inserts a lubricated, gloved finger into the rectum to feel for lumps or abnormal areas. Tight inner thigh muscles can also contribute to pain outside the knee, so you can also carefully foam roll your inner thighs, to see if that helps.



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