Our focus is to obtain expert knowledge in the incidence and prevalence of bladder cancer in specific patient populations and implement screening tests to evaluate the predictive value of these tests. Review of efficacy and long-term compliance of multiple treatments (intracavernous injections, vacuum constriction devices, MUSE- transurethral insertion of alprostatdil and sildenafil citrate) used to treat erectile dysfunction following radical surgeries. Our Center is among the first to conduct novel study to address sexual dysfunction in subset of patients (both male and female) undergoing radical cystectomy. Our ongoing studies are focused on cutting edge issues in the management of erectile dysfunction. We are interested in investigating the potential use of vascular endothelial growth factor gene therapy to stimulate cavernous nerve regeneration after nerve sparing and non-nerve sparing radical prostatectomy and enhance the return of natural erections sufficient for sexual intercourse. To continue our ongoing research on assessment of sexual dysfunction in male and females patients who have undergone radical cystectomy. To assess erectile function after I-125 seed radiation therapy for prostate cancer (T1-2) and the role of sildenafil citrate. Our research interests in bladder cancer are comprehensive, from screening and early detection to monitoring the treatment response of bladder cancer to BCG, to nerve sparing radical cystectomy, and to continent diversion for invasive and metastatic disease. Our basic science research includes studies on the immunologic response to BCG and whether this response can be augmented with various interferons. We are studying the ability of targeted multicolor fluorescence in situ hybridization (FISH) to identify malignant cells in cytological equivocal cases where morphology alone does not allow definitive diagnosis. We are conducting an open comparative within patient controlled phase 3 multicenter Study of Hexvix fluorescence cystoscopy and standard cystoscopy in the detection of carcinoma in situ in patients with bladder cancer. Our focus is to expand on this solid foundation and to obtain expert knowledge in the incidence and prevalence of bladder cancer in specific populations and implement screening tests, evaluate the predictive values of these tests, and determine the diagnostic algorithm for early detection of bladder cancer. The research laboratory is interested in the treatment of localized prostate cancer with radical prostatectomy and the associated complications of incontinence and erectile dysfunction (ED). Our clinical research includes the treatment of localized prostate cancer with radical prostatectomy, the associated complications of incontinence and ED, and quality of life issues in urological practice. Erectile dysfunction is an important morbidity factor after the treatment of localized prostate cancer.
Radical cystectomy is the treatment of choice for locally advanced but invasive cancer of the bladder. Early use of vacuum constriction device (VCD) following radical prostatectomy (RP) facilitates early sexual activity and potentially earlier return of erectile function. Role of sildenafil citrate in the management of erectile dysfunction following I-125 seed insertion for localized prostate cancer. Role of sildenafil citrate in management of sexual dysfunction following radical cystectomy.
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Pantoloc Control Tablets 20mg (Pantoprazole) work at the source of the problem of heartburn to prevent the production of excess stomach acid, offering long-lasting relief for up to 24 hours.
Pantoloc Control is an effective treatment for heartburn as it works to prevent the production of excess acid from your stomach, which is what causes discomforting symptoms of acid reflux. The Traveller's Diarrhoea pack is a comprehensive treatment pack that you can buy at OnlineClinic to ensure that you are fully prepared to deal with the potential threat of traveller's diarrhoea while on holiday. Dr Hilary JonesOnlineClinic Medical Advisor"Traveller’s diarrhoea can be a distressing inconvenience while travelling. This highly effective and clinically proven traveller's diarrhoea treatment can be swiftly ordered at OnlineClinic after completing a simple online consultation form. The Traveller's Diarrhoea pack quickly relieves the symptoms of traveller's diarrhoea and significantly shortens the duration of it. Side effects aren't very common, but could possibly include dizziness, headaches and tiredness. The Traveller's Diarrhoea Pack contains four different treatments to provide you with comprehensive and effective treatment against traveller's diarrhoea, as well as relief from the most bothersome symptoms, until the bacteria has managed to work its way through your system or until you are able to visit the doctor. Each medication in the Traveller's Diarrhoea Pack works in different ways to effectively treat traveller's diarrhoea. Salmonella, Escherichia Coli and Shigella are all types of bacteria commonly responsible for causing traveller's diarrhoea. Dioralyte is an oral hydration agent that can be taken to help your body absorb water more effectively to prevent your body from becoming dehydrated during your illness. Imodium slows down that movement of your bowels by influencing contractions inside the intestines. Buccastem in the Traveller's Diarrhoea Pack can provide much needed relief from the nausea and resultant vomiting that is often associated with a bout of traveller's diarrhoea. Ciproxin (ciprofloxacin) – Take one high dose tablet daily in the morning, followed by another tablet 12 hours later. Imodium (loperamide) – At the start take just two tablets, followed by just one tablet after each loose stool. Buccastem (prochlorperazine) – Place one between your gums and upper lips twice until it dissolves, providing relief from vomiting and nausea. Potential side effects associated with this medication can possibly include nausea, itchiness, a rash, loss of appetite, headaches, dizziness, tiredness or vomiting. Take with caution if you have decreased kidney function, heart disease, epilepsy, abnormal muscle weakness, or if you have had a lung, kidney or heart transplant.
Don't take this medication if you have an allergy to quinolone-type antibiotics or if you have a history of tendon disorders caused by quinolone-type antibiotics. It is recommended that Ciproxin shouldn't be taken during pregnancy or whilst breastfeeding.
Take with caution if you have diabetes, liver or kidney disease, severe diarrhoea and vomiting, or if you are a low sodium or potassium diet.
Possible side effects associated with Imodium can potentially include nausea, flatulence, constipation, dizziness, indigestion, sleepiness, headaches, a rash, bloating and a dry mouth.


Do not take Imodium if you constipation, obstruction of the intestines, inflammatory bowel disease, diarrhoea caused by an infection of the gut, or diarrhoea containing yellow or green mucus.
You should talk to a doctor if you intend to take Imodium during pregnancy and whilst breastfeeding.
Possible side effects associated with Buccastem may include dizziness, agitation, drowsiness, difficulty sleeping or a dry mouth.
Take with caution if you are elderly or have heart disease, abnormal muscle weakness, epilepsy, decreased kidney function, an underactive thyroid gland or a slow heart rate.
Do not take Buccastem if you have decreased liver function, epilepsy, Parkinson's disease, an enlarged prostate gland or a history of closed angle glaucoma. For decades, transurethral resection of the prostate (TURP) has been the gold standard surgical treatment for benign prostatic hyperplasia (BPH). Although laser ablation can provide swift symptom relief and quick recovery and minimize the risk of damage to healthy tissue, impotence or prolonged incontinence, some procedures may result in prostate swelling with temporary need for catheterization. Holmium laser enucleation of the prostate (HoLEP) is a minimally invasive treatment for BPH.
Complete excision of the obstructing prostate tissue down to the prostate's encapsulating structures, resulting in a re-treatment rate of less than 2 percent.
Some studies have shown that patients who underwent HoLEP actually had improved erectile function after surgery, but almost all had retrograde ejaculation. Detrusor acontractility is viewed as a relative contraindication to surgical intervention for men with bladder outlet obstruction secondary to BPH.
In a prospective trial of men ages 53 to 85 years, Mayo urologists performed HoLEP on 15 participants with evidence of BPH and bladders that had very little function or contraction ability.
Widely acknowledged as a benchmark BPH procedure, HoLEP requires specialized skills and training. Holmium laser enucleation of the prostate (HoLEP) is a minimally invasive treatment for benign prostatic hyperplasia (BPH). HoLEP is performed transurethrally, using a holmium laser to separate the plane between the prostate gland tissue and the prostate capsule. Mayo Clinic researchers are testing the use of HoLEP for men with hypocontractile or acontractile bladders and BPH.
Watch videos on advances in disease and condition treatment, procedures and surgeries, and select Grand Rounds. Our recent study is focused on early treatment program following radical prostatectomy, a strategy used to help promote early nerve recovery and regeneration following radical surgery. We reported sexual function data in a contemporary radical cystectomy series by using the SHIM (IIEF-5) for males and a modified IFSF for females.
Our laboratory has been at the forefront of clinical research in the area of urinary tumor markers and their role in screening or early detection of bladder cancer. This database identifies patients who have been screened for bladder cancer, have been treated with intravesical chemotherapy, and have undergone radical surgery with continent diversion.
In future, we would like to examine the relationship between levels of reactive oxygen species and the progression of superficial bladder cancer after intravesical therapy. Hexvix contains hexyl-5-aminolevulinate which are precursors of photoactive porphyrins preferentially taken up by bladder cancer cells, which can be utilized for identification and treatment guidance of malignant and pre-malignant lesions. Our interests in this field have been on surgical margin status and the effect of nerve-sparing surgery on incontinence and erectile function. Our research also involves a review of efficacy and long-term compliance of multiple treatments (intracavernous injections, vacuum constriction devices, MUSE- transurethral insertion of alprostatdil and sildenafil citrate) used to treat ED following radical surgeries. In the past, the majority of the patients were elderly, where post-radiation potency was not a major factor in their decision to undergo radiation.
Outcome data following radical cystectomy with or without orthotopic diversion has focused primarily on cure, urethral recurrence, and continence.
These tablets contain Proton Pump Inhibitor (PPI) which stops excess acid from becoming produced - therefore lessening the chances of discomfort.
The most commonly reported ADRs are diarrhoea and headache, both occuring in approximately 1% of patients. This treatment pack contains four different treatments, which together can help to effectively relieve symptoms, reduce dehydration and significantly shorten the duration of traveller's diarrhoea. Ordering this treatment pack at OnlineClinic ensures that you are completely prepared before travelling to a destination where there is a high risk of traveller's diarrhoea. Once this is approved, your treatment pack will be quickly delivered to you via our fast and completely free next day delivery service. When travelling to areas with a high risk of traveller's diarrhoea, buying the Traveller's Diarrhoea pack online from OnlineClinic ensures that you are fully prepared before you travel. Ciproxin has been proven to be particularly effective at targeting these types of bacteria in large numbers. This treatment comes in a number of sachets inside the Traveller's Diarrhoea Pack and contains sodium chloride, sodium citrate, carbohydrates and potassium chloride, which all help your body to replace the valuable electrolytes and fluids that it's likely to lose when you are experiencing diarrhoea. This means that your food is spending more time going through the digestion process, allowing water to be absorbed properly.
It contains prochlorperazine, which blocks receptors in the brain that are responsible for making you feel sick. You can find out more about cookies and manage your preferences by following the link below.
However, depending on surgeon experience, up to 25 percent of patients may experience some type of complication after TURP, including bleeding, hyponatremia, urinary incontinence and erectile dysfunction. Additionally, the long-term durability of ablative procedures has not been widely assessed, and there is a risk of prostate regrowth requiring repeat surgical intervention in some cases.
With the patient under general anesthesia, the surgeon uses the laser to enucleate the prostate gland tissue, leaving just the capsule in place.
Next-day catheter removal with limited swelling generally allows patients to void painlessly and immediately.


Because adenomatous tissue is excised rather than ablated, surgeons can examine specimens for prostate cancer or other abnormalities. The low depth of penetration of the holmium laser causes little damage to healthy tissue, and the risk of excessive bleeding and erectile dysfunction associated with traditional surgical approaches is reduced. All patients experience hematuria for one to two weeks after the procedure, but the need for blood transfusion is low, around 1 percent. Mayo Clinic researchers are testing the use of HoLEP for men with hypocontractile or acontractile bladders. Preoperatively, all participants had catheter-dependent urinary retention for a median of five months (range: three to 60 months).
Mayo Clinic is among the few medical centers in the United States that performs HoLEP procedures at its campuses in Minnesota and Arizona.
Its short- and long-term outcomes are superior to those associated with transurethral resection of the prostate and suprapubic prostatectomy. This procedure allows complete resection of all adenomatous tissue, minimizing the need for future re-treatment. The laboratory is interested in comparing the efficacy and durability of various types of continent reservoirs.
We are involved in studies to assess the results of sildenafil citrate in salvaging erectile function in postprostatectomy patients.
We are involved in studies to assess the results of sildenafil citrate in management of ED following radical prostatectomy. In future we are interested in investigating the potential use of vascular endothelial growth factor gene therapy to stimulate cavernous nerve regeneration after nerve sparing and non-nerve sparing radical prostatectomy and enhance the return of natural erections sufficient for sexual intercourse.
A larger percentage of younger patients are choosing radiation therapy in recent years and therefore, the issue of post-radiation potency is becoming a major concern.
We were among the first to conduct this novel study to address sexual dysfunction in subset of patient's (male & female) undergoing radical cystectomy. Pantoloc can provide you with relief for up to 24 hours at a time and only one tablet should be taken per day. The Diarrhoea Pack is highly effective in relieving the symptoms of traveller's diarrhoea, as well as shortening the duration of this condition. It contains the active ingredient ciprofloxacin, which hampers the bacteria's ability to repair itself when it becomes damaged by the immune system.
It is important that you still attempt to drink as much fluid as possible when attempting to recover from your illness, even if you are taking Dioralyte.
Apart from the benefits of improving hydration, Imodium can also make it more comfortable to travel, as it reduces the amount of time you experience a motion. TURP also subjects patients to risks inherent in any surgical procedure, as well as a hospital stay of one to four days and recovery time of four to six weeks. The surgeon pushes the excised prostate gland tissue into the bladder and then uses a morcellation device to grind up and remove the tissue.
Same-day or next-day hospital discharge is possible when the procedure is performed in a 23-hour observation setting. Cancer is found in about 10 percent of HoLEP procedures, even in patients previously screened. Since normal saline irrigation is used for the procedure, there is no risk of hyponatremia, regardless of prostate size. Postoperatively, all men were able to void spontaneously without need for intermittent catheterization, with 13 participants displaying a return of detrusor contractility, and two participants voiding exclusively by Valsalva efforts. We were among the first to investigate the effects of this new oral medication in patients following radical prostatectomy and to study the impact of the presence or absence of the neurovascular bundles. Using a SHIM (IIEF-5) validated questionnaire for males and a modified IFSF for females, we are assessing sexual function data in a contemporary radical cystectomy series. They are on continuous symptomatic treatment of indigestion or heartburn for 4 or more weeks. Extra Traveller's Diarrhoea Packs can be ordered quickly and easily online by using our simple repeat ordering process. Two Imodium tablets should be taken straight away after you start feeling ill and then every time you experience a loose stool. Transient urinary incontinence is common, but permanent incontinence at one year after the procedure occurs in approximately 1 to 2 percent of patients, depending on the definition and type of incontinence.
We have recently assessed long-term follow-up compliance with sildenafil citrate therapy following radical prostatectomy. We are stratifying the sexual response as per orthotopic diversion to assess the efficacy of sildenafil citrate (in male) for salvaging ED following radical cystectomy. A reminder service will prompt you to buy more Diarrhoea Packs when they're required in the future. Ciproxin comes in a handy single day treatment inside the Traveller's Diarrhoea Pack and should be taken once in the morning and once in the evening at the start of your illness. Although these findings are preliminary, they suggest that HoLEP may be a viable treatment option for men with BPH and hypocontractile or acontractile detrusor muscle. Patients with long-term recurrent symptoms of indigestion or heartburn should see their doctor at regular intervals.
Treatment with acid-reducing medicinal products leads to a slightly increased risk of gastrointestinal infections such as Salmonella, Campylobacter, or C.



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