Edinburgh Clinical Research Facility provides state of the art facilities to support multidisciplinary clinical research locally, nationally and internationally. In 1997 the Wellcome Trust, in collaboration with the English and Scottish Executive Health Departments, launched an initiative to strengthen clinical research in the UK by funding the construction costs of five new Wellcome Trust Clinical Research Facilities. The aim was to provide purpose-built environments for patient-oriented research that were specifically designed to encourage collaborations between basic and clinically trained scientists. As a result of a joint bid submitted by University of Edinburgh and NHS Lothian, Edinburgh was the only Scottish site to receive funding and became the first CRF in Scotland.
Edinburgh CRF adult and paediatric facilities are all accredited under the Medicines and Healthcare products Regulatory Agency (MHRA) Phase I scheme. The scheme aims to make sure trials are as safe as possible and to create public confidence in the regulation of Phase I clinical trials. In addition to the Clinical Service, Edinburgh CRF uniquely comprises four specialist scientific Cores whose role is to provide expert support for research in humans, their tissue or data in compliance with regulatory and legislative research governance frameworks.
The Epidemiology and Statistics Core aims to improve the methodological quality of research projects through the provision of expert statistical input. The Genetics Core is staffed and equipped to provide secure receipt, processing, archiving and analysis of biological samples.

Edinburgh Clinical Research Facility Imaging Core encompasses the Brain Research Imaging Centre (BRIC), the Clinical Research Imaging Centre (CRIC) and our Image Analysis team.
Our team provides a service for small molecule quantitative clinical and preclinical chromatography-mass spectrometry analysis. Edinburgh CRF’s Education programme collaborates with NHS Research Scotland to provide training for clinical research professionals throughout Scotland and beyond. The CRF IT area aims to develop user-friendly web applications to support the needs of clinical research.
Unless explicitly stated otherwise, all material is copyright © The University of Edinburgh 2016. Our Scientific Cores and Specialist Support Services have over fifteen years’ experience in supporting high quality, high impact research with a particular focus on experimental medicine.
The original Wellcome Trust award funded a purpose built facility (WTCRF) on the Western General Hospital site.
Organisations in the scheme have to exceed the basic regulatory good clinical practice (GCP) standards by having additional procedures that include the highest standards for avoiding harm to trial subjects and for handling any medical emergencies. Our team can provide support for your clinical research from sample collection to genetic analysis, working to the principles of Good Clinical Practice for Laboratories.

Image Analysis is central to conducting successful and meaningful medical imaging research projects.
We have established a number of validated quantitative assays and also develop novel analytical methods for quantitative analysis and metabolite identification tailored to researcher-specific questions and needs. CRFManager® is a custom built application designed in-house to support the administrative requirements of the CRF from study set up, through patient booking to invoicing and reporting. This was quickly followed by the opening of a facility embedded in the new Royal Infirmary at Little France (RIECRF). Our image analysis facilities are equipped with high-spec workstations and specialised software packages.
Our paediatric facility (Children’s CRF) is currently housed in the Royal Hospital for Sick Children at Sciennes, and will be moving to purpose built and expanded accommodation in the new Sick Children’s Hospital at Little France.

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