The goal is to come up with a combination of antibodies that can fight the virus, which spreads via blood or other bodily fluids of an infected person. Scripps professor Erica Ollmann Saphire will lead a team that includes researchers from U.S. TSRI will get $2.5 million to lead the study against the virus, which causes Ebola hemorrhagic fever. Saphire’s team will use a technique called X-ray crystallography to study the structure of the antibodies and how they bind to the virus.
TSRI assistant professor Andrew Ward will use electron microscopy, a different technique for studying molecular structures, while professor Dennis Burton will contribute antibodies. The grant will also fund studies into fighting other hemorrhagic fever diseases, such as the Marburg, Sudan and Lassa viruses.
A first-time survey, conducted in parts of the pristine mountain rainforest of southeastern Suriname, South America, has uncovered a rich biodiversity in flora and fauna, including 60 species that could be new to science and a few species that may exist nowhere else on Earth. Scientists documented an impressively large number of species: 1,378 plants, ants, beetles, katydids grasshoppers, fish, amphibians, birds, and mammals. I have conducted expeditions all over the world, but never have I seen such beautiful, pristine forests so untouched by humans. Southeastern Suriname’s mountain forests have numerous streams that are headwaters for the largest rivers in the country. Suriname’s dense forests, low deforestation and spectacular rivers place us in a truly unique position to become a global model of sustainable development. Bottom line: In a 2012 survey in parts of the southeastern Suriname rainforests, led by Conservation International, scientists have documented a very rich biodiversity of plants and animals. A possible new species, this fish resembles the head-and-tail-light tetras well known to freshwater aquarium hobbyists. This snouted tree frog, possibly a new species, belongs to a genus of fast-moving nimble frogs.
Based on the unusual colors of its top back, scientists think this may be a new poison dart frog species. Planthoppers secrete a waxy substance from its abdomen, sometimes forming long strands that may help protect it from predators. During a night walk, the researchers encountered a large wolf spider eating a poison dart frog. The false coral snake may have the vivid colors of venomous coral snakes, but not their toxic venom.
Of the 28 bat species found during the survey, the larger fruit-eating bat (Artibeus planirostris) is most common. The delicate slender opossum is a tree-dwelling marsupial found in forests of the Guiana shield.
Ebola hemorrhagic fever is a disease caused by four different strains of Ebola virus; these viruses infect humans and nonhuman primates.
Symptoms and signs of Ebola virus disease include an incubation period of two to 21 days, starting with abrupt fever, headache, jointand muscle aches, sore throat, and weakness; progression of symptoms include diarrhea,vomiting, stomach pain, hiccups, and rash with more devastating symptoms of internal and external bleeding in many patients. Ebola viruses are mainly found in primates in Africa and possibly the Philippines; there are only occasional outbreaks of infection in humans.
Early clinical diagnosis is difficult as the symptoms are nonspecific; however, if the patient is suspected to have Ebola, the patient needs to be isolated and local and state health departments need to be immediately contacted. There is no standard treatment for Ebola hemorrhagic fever; only supportive therapy is available.
There are many complications from Ebola hemorrhagic fever; the prognosis for patients ranges from fair to poor since many patients died from the disease (death rate equals about 25%-100%). Prevention of Ebola hemorrhagic fever is difficult; early testing and isolation of the patient, plus barrier protection for caregivers (mask, gown, goggles, and gloves), is very important to prevent others from getting infected. Researchers are trying to understand the Ebola virus and pinpoint its ecological reservoirs to better understand how outbreaks occur. Ebola hemorrhagic fever is a viral disease caused by Ebola virus that results in nonspecific symptoms early in the disease and often causes internal and external hemorrhage (bleeding) as the disease progresses. Ebola hemorrhagic fever was first noted in Zaire (currently, the Democratic Republic of the Congo or DRC) in 1976.
The cause of Ebola hemorrhagic fever is Ebola virus infection that results in coagulation abnormalities, including gastrointestinal bleeding, development of a rash, cytokine release, damage to the liver, and massive viremia (large number of viruses in the blood) that leads to damaged vascular cells that form blood vessels.

The risk factors for Ebola hemorrhagic fever are travel to areas where Ebola infections (see current CDC travel advisories for African countries) have been reported.
Unfortunately, early symptoms of Ebola virus disease are nonspecific and include the following: fever, headache, weakness,vomiting, diarrhea, stomach discomfort,decreased appetite, and joint and muscle discomfort. Ebola hemorrhagic fever is diagnosed preliminarily by clinical suspicion due to association with other individuals with Ebola and with the early symptoms described above. According to the CDC and others, standard treatment for Ebola hemorrhagic fever is still limited to supportive therapy. Ebola hemorrhagic fever often has many complications; organ failures, severe bleeding, jaundice, delirium, shock, seizures, coma, and death (about 50% to 100% of infected patients). The prognosis of Ebola hemorrhagic fever is often poor; the death rate of this disease ranges from about 50% to 100%, and those who survive may experience the complications listed above.
The main way to prevent getting Ebola hemorrhagic fever is to not travel to areas where it is endemic and by staying away from any patients who may have the disease. Research on developing a vaccine against Ebola viruses is ongoing; successful vaccines have been developed that work in experimental animals (mice and guinea pigs but not against macaques monkeys). The disease has mostly been found in Uganda and the Democratic Republic of Congo in recent years, according to TSRI. Army Medical Research Institute of Infectious Diseases, Tulane University, University of Texas, University of Wisconsin, the Public Health Agency of Canada and Uganda Virus Research Institute, among others. Other labs around the world had similar success, and now researchers want to learn which combinations work best, TSRI reported.
A 16-member international team of field biologists published the results of their 2012 survey Results online in October 2013 at the Conservation International website. Southern Suriname is one of the last places on earth where there is a large expanse of pristine tropical forest.
These rivers are essential to the needs of about 50,000 people living in surrounding areas, providing drinking water, food, sanitation, and transportation. The many streams and rivers in southeastern Suriname support a rich diversity of species on land and in the water. We can be water exporters in a world increasingly suffering from droughts and water scarcity, but if we deplete and pollute these biological treasures, our country and the rest of the world will have one less major water resource. This slender tree-dweller uses round disks on its digits to skillfully move about in the treetops. This tiny ruby red insect has antler-like antennae that provide it with a strong sense of smell. She is also a technical editor at an astronomical observatory where she works on documentation for astronomers. Ebola hemorrhagic fever occurs mainly in Africa in the Republic of the Congo, Gabon, Sudan, Ivory Coast, and Uganda, but it may occur in other African countries. Researchers are actively trying to establish an effective vaccine against Ebola viruses by using several experimental methods, but there is no vaccine available currently. Ebola hemorrhagic fever is considered one of the most lethal viral infections; the mortality rate (death rate) is very high during outbreaks (reports of outbreaks range from about 50% to 100% of humans infected, depending on the Ebola strain).
The original outbreak was in a village near the Ebola River after which the disease was named. In addition, association with animals (mainly primates in the area where Ebola infections have been reported) is potentially a risk factor according to the CDC. As the disease progresses, patients may develop other symptoms and signs such as a rash, eye redness, hiccups,sore throat, cough, chest pain, bleeding both inside and outside the body (for example, mucosal surfaces, eyes), and difficulty breathing and swallowing.
Within a few days after symptoms develop, tests such as ELISA, PCR, and virus isolation can provide definitive diagnosis.
Supportive therapy is balancing the patient’s fluid andelectrolytes, maintaining their oxygen status and blood pressure, and treating such patients for any complicating infections. Those patients fortunate enough to survive Ebola hemorrhagic fever still may have complications that may take many months to resolve. Medical caregivers may protect themselves from becoming affected by strict adherence to barriers to the virus (wearing gloves, gowns, goggles, and a mask).
With new and larger outbreaks of Ebola hemorrhagic fever possible, researchers are intensely working to develop an effective vaccine utilizing genetically modified viruses, recombinant viruses, and inactivated Ebola viruses.
Their findings highlight the importance of largely untouched tracts of mountain rainforest in providing a good water supply for people living downstream in more populated areas, which is essential for maintaining a viable economy.

The high number of new species discovered is evidence of the amazing biodiversity of these forests that we have only just begun to uncover. In Suriname, where about 95% of the country is still covered in forest, there is increasing pressure to use these forests for mining, dam construction, and building roads.
In a planet on track to surpass nine billion people by mid-century, we are going to need every drop of fresh water we can get.
This largely untouched forest has streams that feed into major rivers in Suriname, making it a vital economic resource to the country. Said expedition member Trond Larsen, in the press release, “Like other amphibians, its semi-permeable skin makes it highly sensitive to changes in the environment, especially freshwater. Dung beetles play an important role in the forest ecology; by burying dung in the ground, they remove parasites from the ground surface, bury seed that may in the dung for future germination, and provide nutrients for plants.
Scientists found a large and diverse population of fish during their survey, including big fish that are an important source of food for people.
As their name implies, the frog’s poison is applied to the tips of blowdarts used for hunting by some indigenous people in Central and South America.
In their press release, the researchers say, “this species is indicative of pristine, primary forests, and is one of the 39 species of small mammals (rats, bats, opossums) discovered on the expedition. This uncontrolled bleeding leads to blood and fluid loss and can cause hypotensive shock that causes death in many Ebola-infected patients. Ebola virus disease symptoms and signs may appear from about two to 21 days after exposure (average is eight to 10 days).
Later in the disease or if the patient recovers, IgM and IgG antibodies against the infecting Ebola strain can be detected; similarly, studies using immunohistochemistry testing, PCR, and virus isolation in deceased patients is also done usually for epidemiological purposes. Any patients suspected of having Ebola hemorrhagic fever should be isolated, and caregivers should wear protective garments. Survivors may experience weakness, fatigue, headaches, hair loss,hepatitis, sensory changes, and inflammation of organs (for example, the testicles and the eyes). Currently, there is no vaccine available against the Ebola virus strains that cause Ebola hemorrhagic fever in humans. Conservation International has been helping the Suriname government scientifically evaluate its natural resources, enabling the government to make sustainable choices in future economic development. The researchers noted that while other segments of Suriname are likely to become drier due to climate change, the southeast mountain forests could be more resilient, becoming an important resource in the future.
The upper watersheds of southeast Suriname, they think, may also be spawning sites for important migratory fish species. It is unclear why some patients can survive and others die from this disease, but patients who die usually have a poor immune response to the virus. Since that time, there have been multiple outbreaks of Ebola virus, and five strains have been identified; four of the strains are responsible for the high death rates.
During Ebola hemorrhagic fever outbreaks, health-care workers and family members and friends associated with an infected person are at the highest risk of getting the disease.
The four Ebola strains are termed as follows: Zaire, Sudan, Tai Forest, and Bundibugyo virus, with Zaire being the most lethal strain.
Researchers who study Ebola hemorrhagic fever viruses are also at risk of developing the disease if a laboratory accident occurs.
The strain infects primates, pigs, and humans and causes few if any symptoms and no deaths in humans.
Most outbreaks of the more lethal strains of Ebola have occurred in Africa and mainly in small- or medium-sized towns. However, in this new outbreak that began in Africa in March 2014, some of the infected patients have reached larger city centers and have been hospitalized. Unfortunately, many people may have been exposed to the virus in the city, thus causing more infections (and deaths). This outbreak in Africa has now spread to Guinea’s capital and has been detected in the neighboring countries of Liberia and Sierra Leone.
The infecting Ebola virus detected this outbreak is the Zaire strain, the most pathogenic strain of Ebola.

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Comments to «Ebola cure found yet usos»

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