This article was co-authored by Dr Alan Woodruff, science communicator at the Queensland Brain Institute. An emerging drug treatment is effective in mice but translating these results to humans will take time. Stroke claims five million lives worldwide each year and is the second biggest killer after ischaemic heart disease. Current treatment for ischaemic stroke, which results from a blood clot, aren’t very effective.
By 2020, the World Health Organization predicts that worldwide, the number of years lost to disability resulting from stroke will reach 61 million.
If patients are treated within around three hours of the stroke, the stroke-inducing clots can be broken down relatively efficiently using a substance called tissue plasminogen activator (tPA). But after the clot is removed and blood starts flowing, the body produces an unwanted neuroimmune response. These cytokines are able to recruit many other immune cells to the area, leading to further cell death. Limiting the initial release of these cytokines should therefore help to decrease the excessive local inflammatory response, leading to a decrease in tissue damage and better patient outcomes. In collaboration with Garrie Arumugam from the University of Queensland, researchers at Monash University and international colleagues in London and Hamburg, we induced strokes in mice to demonstrate that – as expected – PI3K? controlled the release of TNF-? from immune cells of the central nervous system. This suggested to us that by inhibiting PI3K? activity, we would be able to prevent the rise in TNF-? secretion and therefore limit inflammation of the brain and cell death.
Two separate lines of evidence indicated this was the case: mice genetically modified to have inhibited PI3K? activity had only limited TNF-? release, and mice that were given the PI3K?-inhibiting drug CAL-101 showed similar effects. Further, blocking PI3K? activity (through genetic manipulation or medication) decreased blood clot-induced brain damage and resulted in improved performance on neurological tests. These results indicate that we successfully identified a pathway critical to post-treatment inflammation of the brain, and that we could limit the damage by blocking PI3K?, a key molecule within that pathway. While the genetic manipulation played a role in identifying the signalling pathway involved, it is the efficacy of CAL-101 that is particularly exciting and relevant to stroke therapy. Since initial stroke treatment is typically initiated by medically trained staff, CAL-101 (or a related molecule) could potentially be injected alongside tPA to reduce inflammation of the brain and improve patient outcomes. The next obvious question is whether CAL-101 or a similar derivative may ultimately be used to improve stroke treatment in humans.
Our study was conducted in mice, and translating findings in animal models to the development of clinical therapies can be very difficult – clinical trials of drugs fail frequently due to safety or efficacy concerns. In positive news, however, CAL-101 (also known as GS-1101 or idelalisib) has recently undergone phase three clinical trials in the United States for the treatment of certain forms of lymphoma and the results look promising. Coronary heart disease is almost always a consequence of atherosclerosis; a build-up of cholesterol and other material in the walls of our arteries. Aging Male a€“ a concept meaning the aging of a mana€™s organism and every process that is connected with it.
Men (also those who are elderly gentlemen, wealthy and who are perfectionists) suffer from depressions and potency disorders, are 3 times more likely to commit suicide than women.
Abdominal circumference bigger than 102 cm in men is a serious risk of cardiovascular diseases (heart attack, stroke), diabetes and decreased testosterone level.
The main symptoms of testosterone deficiency, that can occur with age are: decreased libido, erectile dysfunction, decreased strength and muscle mass while increased fat tissue, increased irritability and distraction, greater tendency to depression.
Anabolic steroids (chemicaly modified testosterone molecules) are dangerous and harmful to our health.
Potency pills, (Viagra, Cialis or Levitra) do not work on up to 40% of men (so called "Non-Responders"). Yohimbin a€“ is a substance isolated from the bark of an African plant (Corynanthe yohimbe) and it has been used to improve potency for ages.

L-Arginine as a diet supplement, , w in the right doses, can have positive effects in the treatment of slight erectile dysfunction. Balding (AGA a€“ Androgenetic Alopecia, the most common form) a€“ is a genetic process, and its progress depends on the androgens and age of a person; it affects about 65% of 60-70 year olds and almost 50% of 50 year olds . The one, medically proven medicine that is effective in prevention of bolding process is the therapy of 2-5% Minoxidil (RegaineA®) or 1mg Finasterid (PropeciaA® - Warning a€“ one of the side effects of the therapy is the decrease in libido). Piriformis muscle (musculus piriformis) and iliococcygeus muscle (masculus illiococcygeus), which take part in a sexual intercourse, are very important in the learning of the worlda€™s most sexy dance a€“ Tango Argentino.
Some of the scientific studies suggest the important role of the sounds made during the sexual intercourse and their positive influence on erotic sensations.
The risk of potency disorders is 40% bigger among smokers than among people who do not use tobacco. The research was supported by a National Health and Medical Research Council of Australia (NHMRC) project Grant 1005964 and Prof Frederic Meunier is a Senior Research Fellow of the NHMRC.
We use a Creative Commons Attribution NoDerivatives licence, so you can republish our articles for free, online or in print.
Of those who survive, a significant number (around five million) live with neurological deficits that profoundly affect their quality of life.
But research published by my colleagues and I today in the journal Nature Communications shows an emerging drug treatment is effective in mice and could one day reduce the neurological impact in people who’ve suffered an ischaemic stroke. This allows the blood to start flowing again, supplying the brain with the oxygen required to keep the tissue alive. This occurs because the damaged brain tissue contains elevated levels of molecules known as proinflammatory cytokines, which regulate the body’s response to infection, inflammation and trauma. In previous work, we showed that the secretion of TNF-? is dependent on a molecule named phosphoinositide 3-kinase delta (PI3K?). Not only was the drug effective in improving post-stroke recovery, but its effects could be seen when given up to three hours after the clot was removed and blood started flowing. Not only does it treat lymphomas, it has the potential to alleviate the complications that arise following initial stroke treatment. The common thing of all statements here is a fact that they all are scientifically or medically proven.
Two different periods can be distinguished:middle age - between 40 and 65 years of ageseniors age - after age 65! Scientific researches found out that it really can be helpful in the slightest forms of erectile dysfunction (particularly, if the disorders are of mental nature as the substance has relaxing effects).
Every teacher of singing knows that psoas muscle (musculus psoas) is important and indispensible in the learning of singing. Women practically do not have the refraction phase and can climax several times in a short time.
We’re now also looking into other medical conditions that could be improved by reducing inflammation of the brain with CAL-101 or a similar compound. Furthermore, the physiological sensorimotor response of the clitoris does not fade along with the age. The longest life span of men is in Switzerland and Island (and average of 80 years), whereas in Russia and Ukraine is the shortest ( around 62 years). Impotency has a huge impact on the mena€™s psyche and it can lead to many different disorders.

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