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But the news headlines need to be re-written.  While these short-statured people (~4 feet in height) who live in Ecuador have a genetic advantage like no others on the planet, they don’t live much longer than other human populations because they over-consume alcohol and tend to die of accidental deaths, many related to alcohol abuse. The human tragedy is that what generations of humanity have long hoped for, healthy longevity, which these Ecuadorians don’t even have to search for, is squandered on a bottle of booze. Meanwhile, avid longevity seekers who self-administer human growth hormone via injection may be headed in the wrong direction.  For some time now researchers have questioned whether growth hormone injections for otherwise healthy aging adults is wise. It is interesting to learn that humans who are deficient in growth hormone due to deletion of their growth hormone gene, or patients with multiple pituitary hormone deficiency due to a gene mutation, as well as patients with insulin-like growth factor (IGF-1) deficiency due to gene mutations (Laron syndrome), will, despite signs of early aging (wrinkled skin, obesity, bone loss, insulin resistance), typically have a long life reaching ages of 80-90 years. The super-longevity of dwarf mice parallels the recent findings among short-statured humans in Ecuador.  Some reports indicate dwarf mice that exhibit suppressed growth hormone levels live 35-70% longer than normal mice. The mutation that produces unusual longevity in dwarf mice was not discovered until 1996.  Up till that point, only calorie restriction was known to reliably prolong life. The inherited genetic trait that results in marginal secretion of growth hormone due to a mutation located on chromosome 16 results in the aforementioned health benefits which surprisingly are also mimicked by a calorie restricted diet.
If growth-hormone deficient dwarf mice receive growth hormone injections twice-daily from a young age, their growth will improve but their IGF-1 levels also rise.  Growth hormone injections in young dwarf mice adversely affect the health span and lifespan of these growing animals. It has long been known that limited-calorie diets prolong the life span of all living organisms ranging from fruit flies, round worms, mice and primate monkeys.  Fasting, just another name of calorie restriction outside the laboratory, is known to reduce levels of insulin-like growth factor-I (IGF-1) in mice.
Much like dwarfism, calorie restriction decreases the levels of blood sugar and insulin-like growth factor-1 (IGF-1) and postpones cancer, delays senility and inhibits inflammation. Certainly IGF-1 cannot be characterized as troublesome during the growth years, particularly when iron-deficiency anemia is a problem and low IGF-1 levels are common.

It is interesting to note that IGF-1 levels are reduced among pre-menopausal Caucasian females who use birth control (estrogen) pills, but not among African-American pre-menopausal users of birth control pills.  This may help to explain the much higher rate of breast cancer among African-American women in pre-menopause. It appears vitamin D can help produce health levels of IGF-1 with advancing age without inducing tumors. Calorie restriction works epigentically, that is, to switch gene-controlled protein-making on or off.  Genetic predispositions are inherited mutations, whereas epigenetic changes are controlled by the environment (diet, temperature, radiation, etc) but can also be imprinted and passed on to successive generations, particularly if exposure to environmental factors occurs during conception and early development. Measure of inflammation (interleukin-1) in mice with alcohol or alcohol + resveratrol added to their drinking water. Survival of mice on standard diet (control -¦-), resveratrol added to drinking water (-¦-), alcohol added to drinking water (-^-)alcohol plus resveratrol added to drinking water (-x-).
It is not likely public health officials or the alcoholic beverage industry will be adding resveratrol to their brews anytime soon.  It is also not likely that alcohol abusers are in any way interested in overcoming the deleterious effects of alcohol over-consumption by taking resveratrol pills.
Of course, Big Pharma is posing its candidate growth hormone-blocking drug (Somavert) as the next anti-aging pill.  However, its long term efficacy and safety for this drug among healthy individuals with no growth-hormone deficiency disease is yet to be established. Our hormone clinic recommends you either inject HGH subQ in the love handles or 3 inches left or right of the belly button. The First Step: If you are interested in starting a program, contact us for a free consultation.
All of our Board Certified Medical Physicians and Doctors are knowledgeable specialists in prescribing HGH, Testosterone, Sermorelin, and HCG Weight Loss Diet. Nordatropin Pen System is activated with first usage and can be used for three weeks without any refrigeration, Pen will last 4 weeks with refrigeration after which potency might begin to degrade.

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Other reviews show dwarf mice are growth hormone and insulin-growth factor-1 deficient and live 50-64% longer than wild littermates.
The reduced demand for iron to produce hemoglobin in red blood cells, experienced once full childhood growth is achieved, may help explain why IGF-1 becomes a nemesis rather than a friendly growth factor. If our findings are confirmed by further research, resveratrol could be administered to patients with chronic alcoholism to reduce the mortality and liver damage associated with alcohol abuse. Be sure to enter the four digit security code below before sending us your contact information.
Our HRT Doctors have a minimum of 20 years expertise providing legitimate prescription programs for hormone optimization and hormone replacement therapy.
The naked truth about Bio-Identical Hormone Replacement Therapy is a comprehensive book about Hormone Replacement Therapy (HRT) by Suzanne Somers.

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