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03.03.2014

Vaccine for hsv 2013, how long do herpes viruses live on surfaces - Review

Author: admin
We only use your contact details to reply to your request for more information.We do not sell the personal contact data you submit to anyone else. Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes. Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept.
The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M. This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. T cell vaccine research is trying to find safe, effective ways to spur this protective reaction.


However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Of the two serotypes identified, HSV-1 and HSV-2, the former is more common in the United States, but the latter is considered more serious. Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases. Tenofovir has been shown in some studies to reduce the risk of acquiring HIV, and in some studies there was also a reduction in the frequency of HSV-2 acquisition, but this is the first time that it is being tested as a drug specifically for HSV-2. According to Medscape, approximately 65% of the United States population is seropositive for HSV-1 by the fourth decade of life. As well, approximately 25% of the United States population is seropositive for HSV-2 by the fourth decade of life, with women being infected more frequently than men.


But under a grant from the National Institute of Allergy and Infectious Diseases Division of the National Institutes of Health (NIH), the effort mounted by Vical is directed at developing a plasmid DNA-based vaccine to inhibit recurring lesions in patients latently infected with HSV-2. The vaccine also is intended to reduce viral shedding to help prevent transmission to others. And while still in the preclinical stage, results have shown a reproducible statistically significant reduction in viral lesion occurrence in guinea pigs latently infected with HSV-2.Vical's HSV-2 DNA vaccine program, as seen below, involves collaboration with Lawrence Corey's group at the Fred Hutchinson Research Center.



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