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27.10.2014

Vaccine for herpes simplex 2, ozone therapy for herpes - Review

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Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes.
Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept. The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M. Abstract Herpes simplex virus type 2 (HSV-2), a globally sexually transmitted virus, and also one of the main causes of genital ulcer diseases, increases susceptibility to HIV-1.
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This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. T cell vaccine research is trying to find safe, effective ways to spur this protective reaction. However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus.


Effective vaccines to prevent HSV-2 infection are not yet available, but are currently being developed. HSV-2 Vaccine: Current Status and Insight into Factors for Developing an Efficient Vaccine. Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases. To facilitate this process, the latest progress in development of these vaccines is reviewed in this paper. Of the two serotypes identified, HSV-1 and HSV-2, the former is more common in the United States, but the latter is considered more serious.
Tenofovir has been shown in some studies to reduce the risk of acquiring HIV, and in some studies there was also a reduction in the frequency of HSV-2 acquisition, but this is the first time that it is being tested as a drug specifically for HSV-2. A summary of the most promising HSV-2 vaccines tested in animals in the last five years is presented, including the main factors, and new ideas for developing an effective vaccine from animal experiments and human clinical trials.
Experimental results indicate that future HSV-2 vaccines may depend on a strategy that targets mucosal immunity. According to Medscape, approximately 65% of the United States population is seropositive for HSV-1 by the fourth decade of life.


Furthermore, estradiol, which increases the effectiveness of vaccines, may be considered as an adjuvant. As well, approximately 25% of the United States population is seropositive for HSV-2 by the fourth decade of life, with women being infected more frequently than men. Therefore, this review is expected to provide possible strategies for development of future HSV-2 vaccines. But under a grant from the National Institute of Allergy and Infectious Diseases Division of the National Institutes of Health (NIH), the effort mounted by Vical is directed at developing a plasmid DNA-based vaccine to inhibit recurring lesions in patients latently infected with HSV-2. The vaccine also is intended to reduce viral shedding to help prevent transmission to others. And while still in the preclinical stage, results have shown a reproducible statistically significant reduction in viral lesion occurrence in guinea pigs latently infected with HSV-2.Vical's HSV-2 DNA vaccine program, as seen below, involves collaboration with Lawrence Corey's group at the Fred Hutchinson Research Center.



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