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08.08.2014

Vaccine against herpes, is there really a cure for herpes - PDF Review

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Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes.
Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept. The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M.
Genocea Biosciences – Our lead candidate in HSV-2 is GEN-003, a first-in-class, protein subunit, therapeutic T cell vaccine designed to reduce the duration and severity of clinical symptoms associated with moderate-to-severe HSV-2, and to control transmission of the infection. Unlike prior investigational vaccines for HSV-2, GEN-003 is designed as a protein subunit vaccine to induce balanced B and T cell immune responses, which may be critical for addressing infections not sufficiently controlled by the B cell, or antibody, arm of the immune system alone. There is currently no preventive vaccine or cure for HSV-2, and therapeutic options are limited to daily antiviral medications or suppressive therapy.
I would definantly feel relieved and feel like I can life normally again if a cure is on its way. After being hurt, I thought I would only be able to be with someone who had herpes as well. TUESDAY, March 10, 2015 (HealthDay News)—There's a glimmer of hope in the fight against genital herpes: A new study in mice hints at the success of a vaccine against the virus. Researchers at Albert Einstein College of Medicine in New York City report that the vaccine was safe and effective in protecting mice against herpes simplex virus type 2 (HSV-2), the virus that causes genital herpes.


The vaccine also shows indications of being effective against oral herpes, which causes cold sores, according to the authors of the study published March 10 in the online journal eLife. According to the researchers, genital herpes is one of the most common sexually transmitted diseases, affecting about 500 million people worldwide. This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc.
T cell vaccine research is trying to find safe, effective ways to spur this protective reaction. However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus. GEN-003 is an investigational vaccine designed to stimulate T cell and B cell immune responses to potentially reduce the frequency and severity of clinical outbreaks associated with moderate-to-severe Herpes Simplex Virus type 2 (HSV-2) infection. The study will seek to evaluate the safety and tolerability of GEN-003 and its ability to stimulate the immune system, as well as determine the impact of the vaccine upon viral shedding, which is considered to be a marker of disease recurrence and transmission. If approved, GEN-003 would be the first therapeutic vaccine for patients with HSV-2 infection. Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases.


The study will also assess the vaccine’s impact on viral shedding, the process by which the virus can spread between people. If someone doesn’t like you because you have Herpes then they are not the right person for you because a real person who loves you will accept you in sickness AND in health. I just wish I could wear my bathing suit comfortably again I miss the backless shirts one day I wont be covered in bumps till then its something I must live with because I made the wrong choices as a teenager.
At first I didn’t think I would ever get with a guy again, the idea of having to tell a partner or a partner catching it from me just ruined me! Herpes may (hopefully not soon) last a life time but a child is for 18 years but 100x more expensive.
It was one of the hardest things Ive ever had to do in my life but again they thanked me for my honesty and were supportive. I would pray and hope that a cure to get rid of herpes for good would come sooner rather then later.




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Comments to “Vaccine against herpes”

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