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05.07.2014

Upcoming new herpes research, natural health doctor - .

Author: admin
Genital herpes is one of the most common types of sexually transmitted infections (STI) in the United States – as well as one of the most frustrating. The discovery could lead to a vaccine capable of preventing herpes lesions on people who have already contracted the STI – or in other words, a vaccine that could “clinically cure” an individual of herpes symptoms.
The newly identified T-cells, called CD8??+ T-cells, reveal a great deal more information about genital herpes than was initially known. Before this study, researchers believed that herpes reactivation was controlled at the ganglion level of the spinal canal area. Not only did the research team make this significant discovery about the T-cells’ location, they also found that the CD8??+ T-cells are programmed to remain in the skin surrounding the genitals at all times – making them resident memory T-cells. Researchers had originally estimated that herpes reactivated once a month, but the discovery of these ever-present T-cells led Corey and his team to believe the virus actually reactivates once a week or every few days. CD8??+ T-cells were previously known to exist in the gut mucosa, but most of the research on CD8+ T-cells focused on studying them in blood circulation. According to the Centers for Disease Control and Prevention, 776,000 people in the United States are infected with herpes each year, and one out of six people between the ages of 14 and 49 have genital HSV-2 infection.
Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes.
Fluorescent staining shows areas of the cornea affected by herpes virus that infected a man’s eyes.


Studies find that by age 60, virtually all adults carry herpes simplex virus 1 — best known for seeping cold sores but also potentially blinding when it hits the eyes. It’s a tactic that researchers say may also hold promise for attacking HIV, another virus whose habit of hiding out makes it hard to kill, and the herpes zoster virus that causes excruciating shingles. Herpes viruses are best known for causing cold sores and genital lesions but they can also affect the eye, potentially leading to blindness. To block that key LSD1 enzyme, the researchers used an existing antidepressant, called tranylcypromine.
The antidepressant offers proof of concept, researchers say, but if the new method is eventually used on human patients, it’s likely to be in the form of new drugs developed specifically to act on LSD1. Researchers are also trying to fight persistent viruses like HIV by trying to activate the virus; then they attack it with drugs or hope the immune system will clear it from the body.
But herpes viruses are reactivated in nerve cells, so they can potentially cause damage to the nervous system when they kick back up, says Harvard Medical School’s Dr. Kristie says he hopes the paper will stimulate HIV and other virus researchers to explore similar methods, and he sees potential spillover from cancer drugs that target epigenetics into other fields — like virus research. Massachusetts spent $632 million more on health care last year than it was supposed to, according to a new report.
Researchers have identified a subtype of immune cells that suppress outbreaks of genital herpes caused by the herpes simplex virus type 2 (HSV-2).


T cell vaccine research is trying to find safe, effective ways to spur this protective reaction.
However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus. Herpes simplex virus 2, the sexually transmitted disease, infects more than a quarter of people by their forties, the CDC says. From the lab to your doctor’s office, from the broad political stage to the numbers on your scale, we’d like CommonHealth to be your go-to source for news, conversation and smart analysis. Your hosts are Carey Goldberg, former Boston bureau chief of The New York Times, and Rachel Zimmerman, former health and medicine reporter for The Wall Street Journal.



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