Managing herpes simplex, mayo clinic herpes type 2 - Within Minutes

Human herpes simplex virus (HSV) infection in neonates can result in devastating outcomes, including mortality and significant morbidity. Neonatal herpes simplex virus infections in Canada: Results of a 3-year national prospective study. Effect of serologic status and Cesarean delivery on transmission rates of herpes simplex virus from mother to infant.
Recommendations for managing newborns known to have been exposed intrapartum to HSV are based on expert opinion because a randomized trial to compare management options is not feasible.
Regional distribution of antibodies to herpes simplex virus type 1 (HSV-1) and HSV-2 in men and women in Ontario, Canada. Antenatal seroprevalence of herpes simplex virus type 2 (HSV-2) in Canadian women: HSV-2 prevalence increases throughout the reproductive years. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal infection. Managing asymptomatic term infants whose mothers have active lesions at delivery (Figure 1 and Figure 2)Antibodies to HSV-1 or HSV-2 (type-specific HSV antibodies) take approximately three weeks to develop following infection.[41] Their identification is useful in managing NHSV and testing should be performed if available.


Neonatal herpes simplex meningoencephalitis associated with fetal monitor scalp electrodes. Herpes simplex virus infection after vacuum-assisted vaginally delivered infants of asymptomatic mothers. Herpes simplex virus infection in young infants during 2 decades of empiric acyclovir therapy.
Human antibodies to herpes simplex virus type 1 glycoprotein C are neutralizing and target the heparan sulfate-binding domain.
Neonatal herpes simplex: Clinical findings and outcome in relation to type of maternal infection. Safety and efficacy of high-dose acyclovir in the management of neonatal herpes simplex virus infections. Predictors of morbidity and mortality in neonates with herpes simplex infections: The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. Clinicians should speak with a laboratory specialist or infectious diseases consultant when neonatal herpes simplex virus (NHSV) is suspected and laboratory tests are being requested. Detection of viral DNA in neonatal herpes simplex virus infections: Frequent and prolonged presence in serum and cerebrospinal fluid.

Multiplex real-time PCR for the simultaneous detection of herpes simplex virus, human herpesvirus 6, and human herpesvirus 7. Quantitation of viral load in neonatal herpes simplex virus infection and comparison between type 1 and type 2.
Time course of seroconversion by HerpeSelect ELISA after acquisition of genital herpes simplex virus type 1 (HSV-1) or HSV-2. Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. Mothers with herpes labialis should wear a disposable mask when caring for their infant <6 weeks of age, until lesions are crusted.
There is no contraindication to breastfeeding unless there are herpetic lesions on the breast.

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